Clinical significance of MicoRNA‐155 expression in human breast cancer

Abstract

MiR-155 expression might be an independent prognostic factor and a therapeutic target for human breast cancer.

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

“…Patients were of a variety of carcinomas, including breast cancer, pancreatic ductal adenocarcinomas, esophageal cancer, hepatocellular carcinoma, leukemia, colorectal cancer, lung cancer and lymphoma. Of all the 28 studies, 16 studies (n = 2536) with HR data could be included for metaanalysis [7,[13][14][15][16][17][18][33][34][35][36][37][38][39][40][41]. Among them, seven studies (n = 1678) recruited lung cancer patients.…”

“…Interestingly, miR-155 was recently revealed to have prognostic value in some retrospective or prospective studies. For instance, Chen et al, Greither et al, Han et al, Shibuya et al and Yanaihara et al reported higher expression of miR-155 indicating poorer survival in various cancers with hazard ratios (HR) more than 1 and P values less than 0.05 [7,[13][14][15][16]. However, other studies presented different results.…”

MicroRNA-155 Expression has Prognostic Value in Patients with Non-small Cell Lung Cancer and Digestive System Carcinomas

“…Several studies have corroborated this finding in lung cancer and other malignant diseases including colorectal cancer, breast cancer, hepatocelluar carcinomas, pancreatic ductal adenocarcinomas and adult T-cell leukemia (Raponi et al, 2009;Greither et al, 2010;Shibuya et al, 2010;Chen et al, 2012;Han et al, 2012;Huang et al, 2012;Ishihara et al, 2012;Papaconstantinou et al, 2012); however, other reports provided insignificant or opposite evidences (Jung et al, 2009;Voortman et al, 2010;Donnem et al, 2011;Saito et al, 2011;Monsálvez et al, 2012;Shinmei et al, 2012). In order to investigate the precise association between miR-155 expression and the prognosis of patients, we combined the HRs extracted from the eligible data, and found that patients with high miR-155 expression were likely to have an unfavorable outcome.…”

The Oncogenic Role of miR-155 in Breast Cancer

“…Studies show the expression level of miR-155 is upregulated in breast cancer with high levels of miR-155 associated with clinicopathologic markers, tumor subtype, and poor survival rates, summarized in Table 1 (21,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). Of 29 miRNAs found to be dysregulated in breast cancer, the majority were downregulated, with only miR-155 and miR-21 significantly upregulated (25).…”