Clinical Significance of Mean Platelet Volume Combined with Neutrophil–Lymphocyte Ratio in Predicting the Therapeutic Effect of Splanchnic Neurolysis

Dai, Junzhu; Han, Yuxiang; Fang, Tianyi; Shao, Hongxue; Teng, Lei; Zou, Huichao

doi:10.2147/jir.s428641

JIR

2023

DOI: 10.2147/jir.s428641

|View full text |Cite

Clinical Significance of Mean Platelet Volume Combined with Neutrophil–Lymphocyte Ratio in Predicting the Therapeutic Effect of Splanchnic Neurolysis

Junzhu Dai,

Yuxiang Han,

Tianyi Fang

et al.

Abstract: In most cases of pain related to abdominal tumors, increasing the dosage of analgesics still makes the pain difficult to alleviate. Splanchnic neurolysis is a new treatment option. However, not all patients receiving splanchnic neurolysis treatment will achieve satisfactory results. The aim of this study is to retrospectively analyze the predictive value of preoperative serum immune indicators (white blood cells, neutrophils, lymphocytes, and platelets) for the efficacy of splanchnic neurolysis. Methods: The a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 32 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…

We recently with great interest read the report from Dai et al 1 Their study aimed to retrospectively analyze the predictive value of mean platelet volume (MPV) combined with the neutrophil-lymphocyte ratio (NLR) for the efficacy of splanchnic neurolysis. The results revealed that MPV has statistical significance for predicting splanchnic neurolysis efficacy in digestive system tumors.

…”

mentioning

confidence: 99%

Clinical Significance of Mean Platelet Volume in Predicting the Therapeutic Effect of Splanchnic Neurolysis [Letter]

Zeng

2023

JIR

View full text Add to dashboard Cite

We recently with great interest read the report from Dai et al. 1 Their study aimed to retrospectively analyze the predictive value of mean platelet volume (MPV) combined with the neutrophil-lymphocyte ratio (NLR) for the efficacy of splanchnic neurolysis. The results revealed that MPV has statistical significance for predicting splanchnic neurolysis efficacy in digestive system tumors. MPV and NLR are independent predictors in predicting splanchnic neurolysis efficacy in pancreatic cancer. The authors concluded that the combined detection of MPV and NLR has important clinical predictive value for the postoperative efficacy of splanchnic neurolysis in pancreatic cancer. Although the result was attractive, there are some points that should be noticed.As a crucial biomarker of platelet size and platelet activation, MPV also demonstrated the association with many disorders, including tumors, cardiovascular diseases, infectious diseases and immune diseases. [2][3][4] In these disorders, MPV levels associated with the prognosis or disease serious stage. On the other hand, these underlying disorders (including TNM stages of tumor, cardiovascular diseases, metabolic syndrome, renal diseases, diabetes and infectious diseases, etc.) might also increase or decrease the MPV levels. Moreover, the baseline characteristics, such as age and body mass index, also affected MPV levels. All this information of enrolled subjects could benefit to assess the clinical value of MPV.Second, some drugs and treatment also affected MPV levels, including anti-platelet drugs, anti-tumor drugs, chemotherapy-associated myelosuppression, cancer-associated anemia, erythropoietin and transfusion. 5,6 Many cancer patients might receive these drugs or treatment. The influences of drugs, surgery and transfusion should be considered or provided. Furthermore, some methodological factors could significantly decrease MPV levels, including anticoagulant tubes for blood sample collection, and the time delay between sampling and analysis. 7 Totally, we think that MPV as a prognostic marker for therapeutic effect of splanchnic neurolysis remains debatable. It would be helpful to estimate the predictive role of MPV if the authors provided more details of the study about this above information.

show abstract

“…

…”

mentioning

confidence: 99%

Clinical Significance of Mean Platelet Volume in Predicting the Therapeutic Effect of Splanchnic Neurolysis [Letter]

Zeng

2023

JIR

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Clinical Significance of Mean Platelet Volume Combined with Neutrophil–Lymphocyte Ratio in Predicting the Therapeutic Effect of Splanchnic Neurolysis

Cited by 1 publication

References 32 publications

Clinical Significance of Mean Platelet Volume in Predicting the Therapeutic Effect of Splanchnic Neurolysis [Letter]

Clinical Significance of Mean Platelet Volume in Predicting the Therapeutic Effect of Splanchnic Neurolysis [Letter]

Contact Info

Product

Resources

About