Clinical significance of matrix metalloproteinases-9 and vascular endothelial growth factor expression in the invasion and metastasis of pancreatic carcinoma

Li, Chunlong; Cui, Yunfu; Du, Xue-Fei; Tai, Sheng; Zhong, Xian

doi:10.11569/wcjd.v16.i9.1012

Cited by 45 publications

(54 citation statements)

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“…Furthermore, increased VEGF expression has been reported in cirrhotic and dysplastic liver tissue, suggesting a possible role for VEGF-mediated angiogenesis in hepatocarcinogenesis (El-Assal et al, 1998). VEGF clearly has an important regulatory role in HCC; high levels of VEGF expression have been linked with HCC tumor grade , poor outcome after resection (Poon et al, 2004b), disease recurrence, poor disease-free and overall survival (OS) (Chao et al, 2003), vascular invasion (Li et al, 1998) and portal vein emboli (Zhou et al, 2000).…”

Section: Vegf Receptor Signalingmentioning

confidence: 99%

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

2010

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Section: Vegf Receptor Signalingmentioning

confidence: 99%

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

2010

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“…Therefore, biological markers for predicting HCC reactivation and facilitating disease management must be identified. Vascular endothelial growth factor (VEGF), VEGF receptor-1 (VEGFR-1), and VEGF receptor-2 (VEGFR-2) are strong angiogenesis factors in HCC (Li et al, 1998), play important roles in the development and prognosis of HCC, and correlate with vascular invasion and metastasis (Itoh et al, 2000;Meng and Chen, 2002). However, few studies have been conducted to investigate the role of VEGF polymorphisms in the prognosis of HCC patients receiving TACE treatment.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment

Song¹,

Wang²,

Li³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). In total, 156 patients with histologically confirmed HCC within 2 months were collected from January 2007 to January 2008. The genotypes of VEGF-2578C/A, -1154G/A, -634C/G, and -1498T/C were determined from blood extracted using a blood kit on a 384-well plate. The survival rate at 5 years was 55.47%. Multivariate analysis revealed that only tumornode-metastasis (TNM) stage, metastasis, and the VEGF-2578 AA and -1154 AA genotypes were independent prognostic factors. Patients with TNM stage III-IV and metastasis showed a greatly increased risk of death from HCC, with hazard ratios (HRs) [95% confidence interval (CI)] of 3.64 (1.67-6.79) and 2.91 (1.30-6.27), respectively. Moreover, the VEGF-2578 AA and -1154 AA genotypes showed a significantly increased risk of death compared with the wild-type genotype (HR 8947 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (4): 8946-8953 (2014) VEGF polymorphism and HCC prognosis = 3.65, 95%CI = 1.35-11.13; HR = 7.13, 95%CI = 1.46-65.8). These results will be helpful for predicting clinical outcomes of HCC patients.

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“…The extensive hypervascularity associated with HCC is thought to be driven in part by the proangiogenic factor known as vascular endothelial growth factor (VEGF) (Sun and Tang, 2004;Pang and Poon, 2006). Furthermore, the invasiveness of certain HCC lesions has recently been linked to high levels of VEGF, leading several authors to conclude that an important relationship between VEGF and prognosis exists for HCC (Li et al, 1998;Kanda et al, 2008). Conflicting data, however, have emerged regarding the ability of VEGF to predict disease progression and overall survival (OS) in HCC.…”

mentioning

confidence: 99%

Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis

et al. 2009

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Hepatocellular carcinoma (HCC) is a highly vascular tumour that expresses vascular endothelial growth factor (VEGF). Various studies have evaluated the prognostic value of VEGF levels in HCC. Its overall test performance remains unclear, however. The aim was to perform a systematic review and meta-analysis of prognostic cohort studies evaluating the use of VEGF as a predictor of survival in patients with treated HCC. Eligible studies were identified through multiple search strategies. Studies were assessed for quality using the Newcastle–Ottawa Tool. Data were collected comparing disease-free and overall survival in patients with high VEGF levels as compared to those with low levels. Studies were pooled and summary hazard ratios were calculated. A total of 16 studies were included for meta-analysis (8 for tissue and 8 for serum). Methodological analysis indicated a trend for higher study quality with serum studies as compared to tissue-based investigations. Four distinct groups were pooled for analysis: tissue overall survival ( n =251), tissue disease-free survival ( n =413), serum overall survival ( n =579), and serum disease-free survival ( n =439). High tissue VEGF levels predicted poor overall (HR=2.15, 95% CI: 1.26–3.68) and disease-free (HR=1.69, 95% CI: 1.23–2.33) survival. Similarly, high serum VEGF levels predicted poor overall (HR=2.35, 95% CI: 1.80–3.07) and disease-free (HR=2.36, 95% CI 1.76–3.16) survival. A high degree of inter-study consistency was present in three of four groups analysed. Tissue and serum VEGF levels appear to have significant predictive ability for estimating overall survival in HCC and may be useful for defining prognosis in HCC.

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Clinical significance of matrix metalloproteinases-9 and vascular endothelial growth factor expression in the invasion and metastasis of pancreatic carcinoma

Cited by 45 publications

References 0 publications

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment

Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis

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