Clinical significance of lymphatic and blood vessel invasion in oral tongue squamous cell carcinomas

Michikawa, Chieko; Uzawa, Narikazu; Kayamori, Kou; Sonoda, Itaru; Ohyama, Yoshio; Okada, Norihiko; Yamaguchi, Akira; Amagasa, Teruo

doi:10.1016/j.oraloncology.2011.11.014

Cited by 63 publications

(60 citation statements)

References 27 publications

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“…Elective neck dissection in the clinically negative neck has shown to improve survival [3], however neck dissection is not without complications [4]. In order to identify patients who are likely to have nodal metastases, several primary tumour factors like tumour differentiation, perineural invasion, lymphovascular invasion and tumour thickness have been studied [5][6][7]. Presently it is well recognized that tumour thickness or depth of invasion is an important predictor of nodal metastases in oral cancer [8].…”

Section: Introductionmentioning

confidence: 99%

Tumour thickness as a predictor of nodal metastases in oral cancer: Comparison between tongue and floor of mouth subsites

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Tumour thickness as a predictor of nodal metastases in oral cancer: Comparison between tongue and floor of mouth subsites

et al. 2014

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“…Several serum tumour markers have been evaluated with regard to clinical value in HNSCC and OSCC, but most of them demonstrated poor sensitivity [72,73] . This article focuses on the potential haematogenous spread of tumour cells while OSCC most often spreads in lymphatic vessels [74][75][76] , potentially decreasing the relevance regarding OSCC/HNSCC. However, there are increasing signs that CTCs are clinically relevant in the pathogenesis and recurrence of head and neck tumours.…”

Section: A Discussion Of the Results From Studies On Head And Neck Camentioning

confidence: 99%

Squamous cell carcinoma of the oral cavity and circulating tumour cells

Wikner

Gröbe

Pantel

2014

WJCO

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Due to a lack of substantial improvement in the outcome of patients suffering from oral squamous cell carcinoma (OSCC) during the past decades, current staging methods need to be revised. This disease is associated with poor survival rates despite considerable advances in diagnosis and treatment. The early detection of metastases is an important indicator of survival, prognosis and relapse. Therefore, a better understanding of the mechanisms underlying metastasis is crucial. Exploring alternative measures apart from common procedures is needed to identify new prognostic markers. Similar to previous findings predominantly for other solid tumours, recently published studies demonstrate that circulating tumour cells (CTCs) and disseminated tumour cells (DTCs) might serve as prognostic markers and could supplement routine staging in OSCC. Thus, the detection of CTCs/DTCs is a promising tool to determine the individual need for therapeutic intervention. Encouraging results and new approaches point to the future use of targeted therapies for OSCC, an exceedingly heterogeneous subgroup of head and neck cancer. This review focuses on summarising technologies currently used to detect CTCs/DTCs. The translational relevance for OSCC is highlighted. The inherent challenges in detecting CTCs/DTCs will be emphasised. Core tip: Oral squamous cell carcinoma (OSCC), among head and neck cancer, is related to poor survival rates despite considerable advances in diagnosis and treatment. Therefore, detecting tumour cell dissemination early and understanding the underlying mechanisms are crucial for predicting prognosis, relapse and survival. According to previous findings, circulating tumour cells (CTCs) and disseminated tumour cells (DTCs) might serve as prognostic markers to supplement routine staging and support determining individual therapeutic interventions. This review focuses on summarising the current knowledge about the detection of CTCs/DTCs with special emphasis on patients suffering from OSCC. The translational relevance of CTCs/DTCs and challenges for clinical application are highlighted.Wikner J, Gröbe A, Pantel K, Riethdorf S. Squamous cell carcinoma of the oral cavity and circulating tumour cells.

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“…Monoclonal anti-podoplanin, clone D2-40, is a reliable lymphatic endothelial cell marker which identifies podoplanin in lymphatic endothelium [24,25,45]. In many cancers, the role of podoplanin has associated with tumor progression and metastasis [46].…”

Section: Discussionmentioning

confidence: 99%

“…D2-40 was originally recognized as an oncofetal antigen, M2A antigen, which is an O-linked sialoglycoprotein with a simple mucintype carbohydrate epitope associated with germ-cell neoplasms [24,25]. Currently, it is known that podoplanin and M2A antigen are identical proteins [25].…”

Section: Introductionmentioning

confidence: 99%

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

Seppälä

Pohjola

Laranne

et al. 2016

Eur Arch Otorhinolaryngol

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Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in tongue cancer. Paraffin-embedded tongue and lymph node specimens (n = 113) were stained immunohistochemically with a polyclonal antibody von Willebrand factor, recognizing blood and lymphatic endothelium and with a monoclonal antibody podoplanin, recognizing lymphatic endothelium. The relative density of lymphatic vessels was counted by dividing the mean number of lymphatic vessels per microscopic field (podoplanin) by the mean number of all vessels (vWf) per microscopic field. The high relative density of lymphatic vessels (≥80 %) was associated with poor prognosis in tongue cancer. The relative density of lymphatic vessels predicted poor prognosis in the group of primary tumor size T1-T2 and in the group of non-metastatic cancer. The lymphatic vessel density and diameter of lymphatic vessels were not associated with tongue cancer survival. The relative density of lymphatic vessels might have clinically relevant prognostic impact. Further studies with increased number of patients are needed.

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Clinical significance of lymphatic and blood vessel invasion in oral tongue squamous cell carcinomas

Cited by 63 publications

References 27 publications

Tumour thickness as a predictor of nodal metastases in oral cancer: Comparison between tongue and floor of mouth subsites

Tumour thickness as a predictor of nodal metastases in oral cancer: Comparison between tongue and floor of mouth subsites

Squamous cell carcinoma of the oral cavity and circulating tumour cells

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma

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