Clinical significance of lymph node micrometastasis of pN0 esophageal squamous cell carcinoma

Matsumoto, Masataka; Natsugoe, Shoji; Nakashima, Saburo; Sakamoto, Fumiko; Okumura, Hiroshi; Sakita, Hironori; Baba, Masamichi; Takao, Sonshin; Aikou, Takashi

doi:10.1016/s0304-3835(00)00374-8

Cited by 60 publications

(41 citation statements)

References 20 publications

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“…The percentage of patients with lymph node micrometastasis among those with pN0 ESCC ranges from 17% [13] to 55.5% [12]. Our results showed that 26.4% of patients had micrometastases as determined by anticytokeratin antibody (AE1/AE3).…”

Section: Discussionmentioning

confidence: 67%

“…As more sections are cut from tissue blocks, more micrometastasis might be found in the lymph nodes. However, the lowest positive rate (17%) was reported when ®ve sections per node were analyzed [13] and the highest positive rate (55.5%) was reported when only one section was assessed [12]. A study using a speci®c antiepithelial cell antibody, Ber-Ep4, yielded a high positive rate of 50% in ESCC and micrometastasis was found even in patient with carcinoma in situ (Tis) [9].…”

Section: Discussionmentioning

confidence: 99%

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Clinical implications of lymph node micrometastasis in patients with histologically node‐negative (pN0) esophageal carcinoma

Nakamura

Ide

Eguchi

et al. 2002

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Clinical implications of lymph node micrometastasis in patients with histologically node‐negative (pN0) esophageal carcinoma

Nakamura

Ide

Eguchi

et al. 2002

Journal of Surgical Oncology

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“…It should also be noted that this study analysed only conventional histological factors and did not consider the potential prognostic significance of lymph node micrometastases. Several immunohistochemical studies have shown that up to 50 per cent of all patients diagnosed with N0 disease on routine histological examination have lymph node micrometastases, and this finding is associated with an increased rate of local recurrence 11,12,21 .…”

Section: Discussionmentioning

confidence: 99%

Pathological determinants of survival in node-negative oesophageal cancer

Khan

Alexiou

Soomro

et al. 2004

British Journal of Surgery

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“…Similarly, in patients with advanced cancer, distant lymph nodes should be removed if LNM is found in regional lymph nodes. In patients with carcinoma of the oesophagus and stomach, the reported prognosis was worse in those with LNM (35,(41)(42)(43)(44).…”

Section: Discussionmentioning

confidence: 99%

Rapid immunohistochemical detection of tumor cells in gastric carcinoma

Mönig

Luebke²,

Soheili³

et al. 2006

Oncol Rep

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Abstract. The detection of single tumor cells or tumor cell clusters represents an important issue in intraoperative frozen section analysis. For example, surgical margins may be evaluated in order to minimize the number of additional operations. Furthermore, intraoperative diagnosis of lymph node micrometastasis (LNM) may help to define the area of appropriate lymph node dissection. In addition to haematoxylin and eosin (H&E)-stained sections, immunohistochemical detection of single tumor cells or cell clusters may be helpful in this context. The aim of this study was to evaluate the clinical significance, reliability and sensitivity of intraoperative rapid immunostaining of frozen sections. Therefore, we compared the results of rapid immunohistochemical staining of frozen sections and paraffin sections applying the EnVision™ and Histofine ® detection systems. In a prospective immunohistochemical study, paraffin and frozen sections of 20 gastric cancer specimens were analyzed. Paraffin as well as frozen sections were stained immunohistochemically applying the EnVision and Histofine detection systems. As primary antibodies, AE1/AE3 (anti-cytokeratin), EMA (anti-MUC1) and B lymphocyte marker anti-CD20 were applied. The rapid immunostaining procedure was able to be completed within 10-13 min. Rapid immunohistochemical staining of frozen and paraffin sections of the same tumors resulted in comparable immunoreactivity. The rapid EnVision and Histofine procedures allowed immunostaining of frozen sections in less than 13 min. These methods can represent useful additional tools in routine surgical pathology and research, enabling a more accurate frozen section diagnosis compared to staining with H&E alone. Intraoperative rapid immunostaining can be a simple and useful technique to detect LNM.

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Clinical significance of lymph node micrometastasis of pN0 esophageal squamous cell carcinoma

Cited by 60 publications

References 20 publications

Clinical implications of lymph node micrometastasis in patients with histologically node‐negative (pN0) esophageal carcinoma

Clinical implications of lymph node micrometastasis in patients with histologically node‐negative (pN0) esophageal carcinoma

Pathological determinants of survival in node-negative oesophageal cancer

Rapid immunohistochemical detection of tumor cells in gastric carcinoma

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