Clinical significance of long noncoding RNA MNX1-AS1 in human cancers: a meta-analysis of cohort studies and bioinformatics analysis based on TCGA datasets

Chen, Kang; Gan, Jing; Huang, Zhichao; Liu, Jun; Liu, Haipeng

doi:10.1080/21655979.2021.1888596

Cited by 6 publications

(7 citation statements)

References 41 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 30 High MNX1-AS1 levels are correlated with poor survival outcome and aggressive clinicopathological characteristics in various cancers, suggesting that MNX1-AS1 may be applied as a prognostic marker and even a therapeutic target. 31 In the miRNA–lncRNA pair centered regulatory network consisting of competing triplets in ovarian cancer, AC099850.4 is one of the top five lncRNAs with the most connections. 32 Studies have shown that LINC02154 is significantly upregulated in renal cell carcinoma, and its high expression is one of the risk factors for poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

A Novel Ferroptosis-Related lncRNA Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma

Dang

Jin

Nan

et al. 2022

IJGM

View full text Add to dashboard Cite

Papillary renal cell carcinoma (PRCC) is a common renal cell carcinoma. Recent studies have reported that ferroptosis is involved in the occurrence and development of tumors. Long non-coding RNAs can be used as independent biomarkers for the diagnosis and prognosis of a variety of tumors. Methods: Gene expression profile and clinical information of patients with PRCC were obtained from The Cancer Genome Atlas (TCGA) database. Lasso penalized Cox regression and univariate Cox regression analysis were utilized for model construction. The Kaplan-Meier (K-M) and receiver operating characteristic (ROC) curves were plotted to validate the predictive effect of the prognostic signature. Immune cell infiltration and immune function were compared between the high-risk and low-risk groups. Chemotherapy sensitivity analysis was also performed. Results: We constructed a prognostic signature consisting of 15 ferroptosis-related lncRNAs. The K-M curves validated the fine predictive accuracy of the prognostic signature (p < 0.001). The area under the curve (AUC) of the lncRNA signature was 0.930, exhibiting robust prognostic capacity. The high-risk group had a greater degree of immune cell infiltration than the low-risk group. Significant differences in inflammation promotion, parainflammation, and type I IFN response were noted between the low-risk and high-risk groups (p < 0.01). The expression levels of immune checkpoints including CD80, IDO1, and LAG3 were significantly higher in the high-risk group than in the low-risk group (p < 0.05). Chemotherapy sensitivity analysis showed that MNX1-AS1, ZFAS1, MIR4435-2HG, and ADAMTS9-AS1 were significantly correlated with the sensitivity of some chemotherapy drugs (p < 0.05). Conclusion:We demonstrated that a ferroptosis-related lncRNA prognostic signature could be a novel biomarker for PRCC.

show abstract

Section: Discussionmentioning

confidence: 99%

A Novel Ferroptosis-Related lncRNA Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma

Dang

Jin

Nan

et al. 2022

IJGM

View full text Add to dashboard Cite

show abstract

“…AL355102.4 was downregulated in clear cell renal cell carcinoma samples and indicated good prognosis when lowly expressed, which revealed that AL355102.4 tended to be risk factors with higher gene expression [18]. High MNX1-AS1 level correlated with poor survival outcome and aggressive clinicopathological characteristics in various cancers, suggesting that MNX1-AS1 may be applied as a prognostic marker and even a therapeutic target [19]. In the miRNA-lncRNA pair centered regulatory network consisted of competing triplets in ovarian cancer, AC099850.4 is one of the top ve lncRNAs with most connections [20].…”

Section: Discussionmentioning

confidence: 99%

A Novel Ferroptosis-Related Lncrnas Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma

Mei

2021

Preprint

View full text Add to dashboard Cite

BackgroundPapillary renal cell carcinoma (PRCC) is a common renal cell carcinoma. Recent studies have reported that ferroptosis is involved in the occurrence and development of tumors. Long non-coding RNAs could be used as independent biomarkers for the diagnosis and prognosis of a variety of tumors, and many lncRNAs are related to the pathogenesis of PRCC. However, there are few studies on the ferroptosis-related lncRNAs of PRCC. This study aimed to establish ferroptosis-related lncRNAs prognostic signature in patients with PRCC.MethodsGene expression profile and clinical information of patients with PRCC were obtained from The Cancer Genome Atlas (TCGA) database. Lasso-Penalzed Cox regression and univariate Cox regression analysis were utilized for model construction. The Kaplan-Meier (K-M) and Receiver Operating Characteristic (ROC) curves were plotted to validate the predictive effect of the prognostic signature. Immune cell infiltration and immune function were compared between the high-risk and low-risk groups. Chemotherapy sensitivity analysis was also performed. ResultsWe constructed a prognostic signature consisted of 15 ferroptosis-related lncRNAs. The Kaplan-Meier curves validated the fine predictive accuracy of the prognostic signature (p < 0.001). The area under the curve (AUC) of the lncRNAs signature was 0.930, exhibiting robust prognostic capacity. The high-risk group had a greater degree of immune cell infiltration, such as B cells, T cell CD8, macrophages, NK cell, etc., compared with the low-risk group. There were significant differences in inflammation-promoting, parainflammation and Type I IFN reponse between the low-risk and high-risk groups. The expressions of immune checkpoints including CD80, IDO1, LAG3, etc. were significantly higher in high-risk group. Chemotherapy sensitivity analysis showed that MNX1-AS1, ZFAS1, MIR4435-2HG and ADAMTS9-AS1 were significantly correlated with the sensitivity of some chemotherapy drugs. ConclusionWe demonstrated that a ferroptosis-related lncRNAs prognostic signature could be a novel biomarker for PRCC. Our findings could provide a new insight for immune research and treatment strategies for patients with PRCC.

show abstract

“…We performed Gene Expression Profiling Interactive Analysis (GEPIA) based on TCGA dataset to further assess the prognostic value of securin expression in patients with solid cancers. [ 33 ] In this analysis, the Kaplan–Meier method and log-rank test were used to compare survival outcomes between patients with high securin expression and those with low expression, and HRs with 95% CIs and P values were presented using the Kaplan–Meier method curve, as previously described. [ 34 ]…”

Section: Methodsmentioning

confidence: 99%

Clinical significance of securin expression in solid cancers: A PRISMA-compliant meta-analysis of published studies and bioinformatics analysis based on TCGA dataset

Liu¹,

Zeng²,

Zheng³

et al. 2022

Medicine

View full text Add to dashboard Cite

Background: Numerous studies have investigated the clinical significance of securin expression in solid cancers; however, the results have been inconsistent. Hence, we performed a meta-analysis of published studies to assess the clinical value of securin expression in patients with solid cancers. Methods: The Chinese National Knowledge Infrastructure, Web of Science, PubMed, and EMDASE databases were searched for eligible studies (from inception up to April 2021). Bioinformatics analysis based on The Cancer Genome Atlas dataset was also performed to evaluate the prognostic value of securin expression. Results: A total of 25 articles with 26 studies were included in the meta-analysis. The results of the meta-analysis implied that high securin expression was positively correlated with unfavorable overall survival (OS) (hazard ratio = 1.52, 95% CI, 1.33–1.73; P < .001) and lymph node metastasis (odd ratio = 2.96, 95% CI, 2.26–3.86; P < .001). Consistently, our bioinformatics analysis showed that increased securin expression was associated with worse OS and shorter disease-free survival in cancer patients. Conclusion: Our study indicated that securin overexpression was positively associated with metastasis and inversely related to the prognosis of patients with solid cancers. However, additional high-quality studies should be conducted to validate these findings.

show abstract

Clinical significance of long noncoding RNA MNX1-AS1 in human cancers: a meta-analysis of cohort studies and bioinformatics analysis based on TCGA datasets

Cited by 6 publications

References 41 publications

A Novel Ferroptosis-Related lncRNA Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma

A Novel Ferroptosis-Related lncRNA Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma

A Novel Ferroptosis-Related Lncrnas Signature for Prognosis Prediction in Patients with Papillary Renal Cell Carcinoma

Clinical significance of securin expression in solid cancers: A PRISMA-compliant meta-analysis of published studies and bioinformatics analysis based on TCGA dataset

Contact Info

Product

Resources

About