Clinical Significance of Joint Detection of CD44v6 and CD62P in Nasopharyngeal Carcinoma

Yang, Jie; Li, Lei; Ren, Yanping; Li, Xiaojiang; Tu, Yanling; Ma, Jing; Sun, Ramon C.; Zhao, Liufang

doi:10.1159/000356041

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Another report showed that both CD24- and CD44-positive populations had stem-like properties under physiological Wnt/beta-catenin signaling [27]. Expression of CD44v6, a splicing variant of CD44, is associated with clinical significance by joint detection of CD62P in peripheral blood of NPC patients [28]. Several reports suggest that CD44v6 has more aggressiveness as the stem cell marker than CD44 [29, 30].…”

Section: Introductionmentioning

confidence: 99%

Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma

Wang

Zhao

et al. 2016

Mediators of Inflammation

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Nitrative and oxidative DNA damage plays an important role in inflammation-related carcinogenesis. To investigate the involvement of stem cells in Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, and ALDH1A1) in NPC tissues and NPC cell lines. We also measured 8-nitroguanine formation as an indicator of inflammation-related DNA lesions. The staining intensity of 8-nitroguanine was significantly higher in cancer cells and inflammatory cells in the stroma of NPC tissues than in chronic nasopharyngitis tissues. Expression levels of CD44v6 and ALDH1A1 were significantly increased in cancer cells of primary NPC specimens in comparison to chronic nasopharyngitis tissues. Similarly, more intense staining of CD44v6 and ALDH1A1 was detected in an NPC cell line than in an immortalized nasopharyngeal epithelial cell line. In the case of CD24 staining, there was no significant difference between NPC and chronic nasopharyngitis tissues. 8-Nitroguanine was detected in both CD44v6- and ALDH1A1-positive stem cells in NPC tissues. In conclusion, CD44v6 and ALDH1A1 are candidate stem cell markers for NPC, and the increased formation of DNA lesions by inflammation may result in the mutation of stem cells, leading to tumor development in NPC.

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Section: Introductionmentioning

confidence: 99%

Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma

Wang

Zhao

et al. 2016

Mediators of Inflammation

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“…These include including PAX8 (implicated in adenocarcinoma and ovarian carcinoma), SELP (nasopharyngeal carcinoma) and RAB40C (gastric cancer). [195][196][197][198] As previously discussed, we hypothesised that the biological causes for LAF varied between the histological groups making it difficult to differentiate all samples based on LAF alone. In support of this, the differential expression profile between the LAF groups within the keratosis/hyperplasia group present different underlying mechanisms to those in the dysplasia group.…”

Section: Discussionmentioning

confidence: 95%

Efficacy of VELscopeTM in clinical practice: Clinical and pathological correlations

Bhatia¹

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Oral cancer is most commonly referred to as cancer of the lip, oral cavity and oropharynx with 90% of oral malignancies being attributed to oral squamous cell carcinomas (OSCC). It is estimated that 263, 900 new cases are diagnosed worldwide per year with 128,000 deaths being attributed to OSCC in 2008 alone. The survival rate has remained unchanged for last three decades at around 50%, largely due to the delayed diagnosis of these cancers. Additionally, OSCC are often preceded by changes to the oral mucosa which can be detected on visual examination. Lesions which have the propensity to progress to malignancy are referred to as oral potentially malignant disorders (OPMD). Therefore, to improve patient outcomes there has been increased emphasis on detecting OSCC and OPMD at an earlier stage, New technologies which assist lesion visualisation have been made available to assist the general and specialist practitioner in detecting OPMD, and also differentiating OPMD from benign lesions. This thesis will focus on VELscope TM , a device which utilises direct tissue autofluorescence to perform this function. When visualised with VELscope TM , normal mucosa is associated with a pale green autofluorescence, while abnormal mucosa is associated with loss of autofluorescence (LAF). It is well reported in the literature that VELscope TM is associated with high sensitivity for the detection of dysplasia but low specificity, and there are concerns regarding the presence of false positives due to inflammatory lesions also displaying LAF. In specialist practice, the device is effective in detecting dysplasia however it can be difficult to distinguish dysplasia from benign inflammatory lesions. Diascopic fluorescence, when the lesion returns to a normal fluorescence pattern under pressure, can help discern inflammatory lesions from those with malignant potential. Additionally, some cases of dysplasia may not display LAF. In general practice, the literature is limited however the main concerns are that relying on VELscope TM alone may lead to gross over referrals.

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Emerging prognostic factors in Nasopharyngeal carcinoma

Iacovelli

Bossi

Fallai

et al. 2014

J Nasopharyng Carcinoma

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Clinical Significance of Joint Detection of CD44v6 and CD62P in Nasopharyngeal Carcinoma

Cited by 3 publications

References 16 publications

Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma

Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma

Efficacy of VELscopeTM in clinical practice: Clinical and pathological correlations

Emerging prognostic factors in Nasopharyngeal carcinoma

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