Clinical significance of incidental focal colorectal <sup>18</sup>F‐fluorodeoxyglucose uptake: our experience and a review of the literature

Treglia, Giorgio; Calcagni, Maria Lucia; Rufini, Vittoria; Leccisotti, Lucia; Meduri, G; Spitilli, Maria Grazia; Dambra, Donatella Pia; Gaetano, Anna Maria De; Giordano, Alessandro

doi:10.1111/j.1463-1318.2011.02588.x

Cited by 69 publications

(82 citation statements)

References 30 publications

(111 reference statements)

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“…Several investigations used lower or no SUV cut-off values [6,13,14]. Gutman et al, who did not use an SUV-cut-off, described 45 incidental colonic focal FDG-uptaking lesions [5].…”

Section: Discussionmentioning

confidence: 99%

Relevance of Incidental Colorectal FDG-PET/CT-Enhanced Lesions

Putora¹,

Müller²,

Borovicka

et al. 2013

Oncol Res Treat

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Introduction: Positron emission tomography/computed tomographies (PET/CTs) may result in incidental findings of fluorodeoxyglucose (FDG)-avid lesions in the colon. The aim of this study was to assess the relevance of a colonoscopic workup of such lesions. Patients and Methods: We retrospectively analysed all PET/CT reports (n = 4,973) generated in our nuclear medicine department between May 2006 and May 2011; in 69 cases a colonoscopic evaluation was recommended for incidental FDG-avid lesions. Results: Of these 69 cases, 51 underwent colonoscopy because of the potential need for further treatment. The maximum standardized uptake values (SUVmax) ranged from 5.0 to 42.0 with an average of 10.9. In 44 of the 51 patients, a histopathological abnormality was found on colonoscopy, 44 in the location described by PET/CT. A further 38 lesions were identified that were not visible on PET/CT. The histopathological evaluation in the 51 patients revealed 14 hyperplastic polyps, 27 adenomas with low-grade and 4 with high-grade dysplasia, 3 adenocarcinomas and 1 neuro-endocrine tumour. Conclusion: Incidental findings of focal colorectal FDG uptake should lead to further workup with colonoscopy. The SUVmax was not predictive for higher grade histologies. With an SUV of 5 the yield was high for colonic premalignant and malignant lesions. However, malignancy cannot be ruled out in focal lesions with an SUV of less than 5, and for individual patients a colonoscopy should not be ruled out.

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“…Several investigations used lower or no SUV cut-off values [6,13,14]. Gutman et al, who did not use an SUV-cut-off, described 45 incidental colonic focal FDG-uptaking lesions [5].…”

Section: Discussionmentioning

confidence: 99%

Relevance of Incidental Colorectal FDG-PET/CT-Enhanced Lesions

Putora¹,

Müller²,

Borovicka

et al. 2013

Oncol Res Treat

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“…A recent study also determined that SUVmax can display malignancy together with metabolic volume (17). Nonetheless, there are several studies that were not able to reach a significant correlation between SUVmax and malignancy but recommended colonoscopy when intense FDG accumulation is determined (18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Güreşçi¹,

Özmen²,

Uzman³

et al. 2016

Turk J Med Sci

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Background/aim: To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region.Materials and methods: SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker.Results: Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions. Conclusion:The Ki-67 proliferation index is an indicator of SUVmax in colorectal tract. SUVmax values can predict malignancy and prognosis in this region. Colonoscopy and biopsy should always be performed whenever a focal high FDG uptake is determined incidentally in a patient.

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“…Incidental and unexpected focal 18 F-fluoro-2-deoxyglucose ( 18 F-FDG) uptakes in many organs are relatively frequent and can involve many organs as thyroid [1,2], prostate [2], parotid gland [3] and colon [4]. Breast incidentaloma is commonly considered a breast lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially not for investigating breast diseases.…”

Section: Introductionmentioning

confidence: 99%

Incidental 18F-FDG PET/CT bilateral breast uptake due to carcinoma

et al. 2016

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We report a case of 71-year-old female patient, previously treated with chemotherapy and surgical resection of sigmoid tract of the large bowel for adenocarcinoma (pT3N1M0), who underwent a 18 F-FDG PET/CT for a suspicious hepatic lesion detected at CT scan during follow-up. 18F-FDG PET/CT showed no abnormal uptake in the liver both at 60 minutes and 120 minutes after injection but revealed a pathological uptake in two breast nodules, (one localized in upper-internal-quadrant of the right breast and the other in the upper-external-quadrant of the left breast). The patient underwent breast MRI, which confirmed the suspicious nature of both lesions; subsequently she underwent a trucut biopsy of both lesions witch demonstrated a bilateral localization of papillary carcinoma (both lesion were classified as pT1c). The patient underwent bilateral mastectomy and the final biopsy confirmed the presence of breast cancer, while bilateral sentinel nodes biopsy showed no lymph-nodes metastases.

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Clinical significance of incidental focal colorectal ¹⁸F‐fluorodeoxyglucose uptake: our experience and a review of the literature

Abstract: Focal incidental colorectal uptake of [(18)F]FDG is observed in about 1% of PET/CT studies and carries a high risk of neoplastic disease. A PET-CT report should suggest colonoscopy when abnormal findings are reported.

Cited by 69 publications

References 30 publications

Relevance of Incidental Colorectal FDG-PET/CT-Enhanced Lesions

Relevance of Incidental Colorectal FDG-PET/CT-Enhanced Lesions

Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Incidental 18F-FDG PET/CT bilateral breast uptake due to carcinoma

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Clinical significance of incidental focal colorectal 18F‐fluorodeoxyglucose uptake: our experience and a review of the literature

Abstract: Focal incidental colorectal uptake of [(18)F]FDG is observed in about 1% of PET/CT studies and carries a high risk of neoplastic disease. A PET-CT report should suggest colonoscopy when abnormal findings are reported.

Cited by 69 publications

References 30 publications

Relevance of Incidental Colorectal FDG-PET/CT-Enhanced Lesions

Relevance of Incidental Colorectal FDG-PET/CT-Enhanced Lesions

Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

Incidental 18F-FDG PET/CT bilateral breast uptake due to carcinoma

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Clinical significance of incidental focal colorectal ¹⁸F‐fluorodeoxyglucose uptake: our experience and a review of the literature