Clinical significance of immunoglobulin G4-associated autoimmune hepatitis

Umemura, Takeji; Zen, Yoh; Hamano, Hideaki; Joshita, Satoru; Ichijo, Tetsuya; Yoshizawa, Kaname; Kiyosawa, Kendo; Ôta, Masao; Kawa, Shigeyuki; Nakanuma, Yasuni; Tanaka, Eiji

doi:10.1007/s00535-010-0323-4

Cited by 104 publications

(108 citation statements)

References 36 publications

(46 reference statements)

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…The IAIHG score in our case was 9, indicating a negative result. The lack of rosette formation or giant cell changes with marked eosinophilic infiltration and bile duct damage was incompatible with a diagnosis of AIH (17,18). Patient with IgG4 hepatopathy in autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (SC) also histopathologically demonstrate chronic hepatitis, lobular necrosis and lymphoplasmacytic infiltration around the portal vein (19).…”

Section: Discussionmentioning

confidence: 99%

Hepatitis Associated with Hypereosinophilia Suspected to be Caused by HES that Also Presented with the Pathological Features of IgG4-related Disease

et al. 2014

View full text Add to dashboard Cite

A 52-year-old woman presented to our hospital due to elevated liver enzyme levels and hypereosinophilia. Liver biopsy specimens revealed chronic hepatitis with abundant eosinophils and immunoglobulin G4(IgG4)-positive plasma cell infiltration. Systemic lymphadenopathy, including that involving the hepatic hilar lymph nodes, was observed on computed tomography, and the cervical lymph node biopsy specimens exhibited lymphoid follicular hyperplasia and IgG4-positive plasma cell infiltration. It is sometimes difficult to distinguish hypereosinophilic syndrome (HES) from IgG4-related disease, as some of the clinical findings overlap. The numerous areas of eosinophilic infiltration observed in the liver indicated a diagnosis of HES in our case.

show abstract

Section: Discussionmentioning

confidence: 99%

Hepatitis Associated with Hypereosinophilia Suspected to be Caused by HES that Also Presented with the Pathological Features of IgG4-related Disease

et al. 2014

View full text Add to dashboard Cite

show abstract

“…However, no features of sclerosing cholangitis, a typical hepatic manifestation of IgG4-related disease, were identified (15). A recent study proposed a comparatively new disease entity named IgG4-associated autoimmune hepatitis (AIH), which accounts for more than 3% of classical AIH cases (16). Of importance, IgG4-associated AIH shows intrahepatic infiltration of IgG4-positive plasma cells despite the absence of radiological abnormalities in the pancreatobiliary system.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Sarcoidosis with an Increased Serum Level of Immunoglobulin G4

et al. 2012

Self Cite

View full text Add to dashboard Cite

A 70-year-old woman with an increased uptake of 18-Fluorodeoxyglucose (FDG) in whole liver on positron emission tomography (PET) was referred to our hospital. Laboratory examinations showed increased serum levels of total immunoglobulin G (IgG) and IgG4. Gallium scintigraphy showed a remarkable uptake in the liver but not in any other organs. On computed tomography (CT) and magnetic resonance imaging (MRI), multiple foci of abnormal density were observed in the liver, but the pancreas and bile duct lacked any indications of IgG4-related sclerosing disease. A liver biopsy specimen revealed multiple non-necrotizing granulomas. This is the first report of hepatic sarocidosis in a patient with an elevated serum level of IgG4.

show abstract

“…The majority of data related to IgG4 AIH is from Japan. [20][21][22][23] To our knowledge there are no reports of IgG4 AIH from India. Aim of this study was to determine IgG4 plasma cells in autoimmune hepatitis and its impact on clinical course and treatment outcome.…”

Section: Introductionmentioning

confidence: 91%