Clinical significance of hypoxia in nasopharyngeal carcinoma with a focus on existing and novel hypoxia molecular imaging

Yip, Connie; Cook, Gary; Wee, Ji‐Hyang; Fong, Kam Weng; Tan, Terence

doi:10.21037/cco.2016.03.16

Cited by 4 publications

(3 citation statements)

References 131 publications

(105 reference statements)

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“…With tumor hypoxia information, the aggressiveness and radio resistance can be assessed qualitatively for planning treatment regimens 36,41 . Studies have shown that BOLD and TOLD are sensitive to hyperoxic gas challenge in brain, 42 breast, 43 cervix, 44 prostate, 45 and head and neck 46 lesions.…”

Section: Other New Fmri Techniquesmentioning

confidence: 99%

Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response

Wong

Cheng

Lam

et al. 2022

Precision Radiation Oncology

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Nasopharyngeal carcinoma (NPC) is a common malignancy endemic in South‐East Asia. Functional magnetic resonance imaging (fMRI) has been used for prompt detection of treatment response before visible morphological changes in NPC treatment. Among different fMRI techniques, diffusion‐weighted imaging (DWI) and dynamic contrast enhancement (DCE) were proved to be more successful in NPC treatment response assessment whilst the application of magnetic resonance spectroscopy (MRS) remains questionable. Apart from discussing the imaging technique, time points for post‐treatment response assessments are recommended. Four instead of three months is recommended for prompt identification of non‐ or partial responders and 6–9 months post‐treatment multiparametric MRI is also recommended for effective confirmation of complete responding individuals to avoid residual disease. For future advancement, in addition to the post‐treatment response assessment, continuous or longitudinal assessment on the treatment response with the use of magnetic resonance simulator (MR‐simulator) or magnetic resonace imaging guided linear accelerator (MR‐Linac) tailor‐made for radiotherapy (RT) maybe feasible. Longitudinal assessments or predictive radiomics modeling allow spotting out the possibility of treatment failure before the completion or even before the start of treatments. Adaptive instead of salvage treatments can then be prepared, thus reducing the damage and side effects of consecutive cytotoxic treatments.

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Section: Other New Fmri Techniquesmentioning

confidence: 99%

Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response

Wong

Cheng

Lam

et al. 2022

Precision Radiation Oncology

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“…The hypothesis was based on the survival correlation of tumor necrosis in photopenic (PP+) regions containing hypoxic but possibly viable and relatively radioresistant cancer cells in comparison to fully oxygenated parts of the tumor without PP (PP-). Though the impact of hypoxia on the survival of NPCs has been studied with various tracers [12][13][14], yet, PP in FDG-PET has never been defined as a prognostic factor to date. Thusly, we hypothesized that PP+ NPC patients may have worse outcomes in comparison to their PP-counterparts after definitive C-CRT.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Photopenia on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Scans Predicts Poor Prognosis in Nasopharyngeal Cancer Patients Undergoing Concurrent Chemoradiotherapy

Topkan¹,

Selek²,

Mertsoylu³

et al. 2020

Clin Exp Otorhinolaryngol

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Objectives. To investigate the influence of pretreatment primary tumor or nodal photopenia (PP) on 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT), an indicator of tumor ischemia, on survival results of nasopharyngeal cancers (NPCs) treated with concurrent chemoradiotherapy (C-CRT).Methods. The pre-C-CRT FDG PET-CT scans of 104 patients with NPC (cT1-4 N0-3 M0) were retrospectively examined to determine the presence of PP (PP+). Our primary endpoint was the influence of PP+ on overall survival (OS), while the progression-free survival (PFS) and locoregional PFS (LRPFS) constituted the secondary endpoints.Results. The PP+ was detected in 29 (27.9%): nine (8.7%), seven (6.7%), and 13 (12.5%) in the primary tumor alone, primary tumor plus neck nodes, and neck nodes alone, respectively. Because the PP+ cases were small by count per location, all comparative analyses were performed according to overall PP+/ PP– status instead of per detected site. At a median follow-up of 67.8 months (range, 9 to 130 months), the median survival times were not reached (NR) for the entire population, while 5-year OS, LRPFS, and PFS rates were 73.3%, 68.2%, and 63.4%, respectively. Comparatively the PP+ patients exhibited significantly poorer median OS (49.8 months vs. NR, P<0.001), LRPFS (40.7 months vs. NR, P=0.001), and PFS (31.8 months vs. NR, P=0.002) durations than their PP– counterparts. Furthermore, the PP+ retained its independent prognostic significance in multivariate analysis (P<0.001).Conclusion. Present results uncovered the pre-C-CRT PP as an independent predictor of poor prognosis for NPC patients, which underscore the requirement for the fortification of the local and systemic treatments in hypoxic NPCs.

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“…Nasopharyngeal carcinoma is a radiotherapy-sensitive tumor, but with the extension of radiotherapy, the percentage of hypoxic cells gradually increased (up to 10 to 50%), and the increased percentage of hypoxic cells can lead to the failure of solid tumor chemotherapy, the recurrence and metastasis of tumors (1). Tumor cell hypoxia on the one hand can reduce the production of oxygen free radicals, resulting in reduction in radiotherapy-induced DNA breakage, on the other hand can increase the release of hypoxia-inducible factor-1 (HIF-1), increase the expression of vascular endothelial growth factor (VEGF), and inhibit tumor cell apoptosis (2).…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptor-9 in hypoxic nasopharyngeal carcinoma cells and its correlation with cell proliferation and apoptosis

2017

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Abstract. The purpose of this study was to investigate the correlation between the expression of Toll-like receptor-9 (TLR-9) and cell proliferation and apoptosis in hypoxic nasopharyngeal carcinoma cells. Human nasopharyngeal carcinoma cell line HNE-1 (EBV positive) and CNE-1 (EBV negative) were used. Cells were divided into normal control group, hypoxia group and hyperoxia group. Hypoxic conditions were 5% CO 2 and 0.01% partial pressure of oxygen, hyperoxia conditions were 5% CO 2 and 10% partial pressure of oxygen. Reverse transcription-PCR (RT-PCR) and western blot analysis were used to detect the expression of TLR-9 mRNA and protein at 6, 12 and 24 h after the beginning of cell culture. MTT assay was used to detect the cell proliferation rate and flow cytometry was used to detect cell apoptosis rate. Expression levels of TLR-9 mRNA and protein in hypoxia group reached the peak at 12 h after the beginning of cell culture, and were significantly higher than those of hyperoxia group at all time-points, expression levels of TLR-9 mRNA and protein of control group were the lowest, difference between groups were all statistically significant (P<0.05). No significant changes in expression levels of TLR-9 mRNA and protein were found in control group and hyperoxia group between different timepoints (P>0.05). Compared with the other two groups, cell proliferation rate was gradually decreased and apoptotic rate was gradually decreased in hypoxia group, significant differences were found between hypoxia group, and control group and hyperoxia group (P<0.05), no significant differences were found between control group and hyperoxia group (P>0.05).In conclusion, TLR-9 was highly expressed in hypoxic nasopharyngeal carcinoma cells regulating cell proliferation and apoptosis, which may be an important mechanism of tumorigenesis and a potential target for intervention therapy.

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Clinical significance of hypoxia in nasopharyngeal carcinoma with a focus on existing and novel hypoxia molecular imaging

Cited by 4 publications

References 131 publications

Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response

Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response

Pretreatment Photopenia on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Scans Predicts Poor Prognosis in Nasopharyngeal Cancer Patients Undergoing Concurrent Chemoradiotherapy

Toll-like receptor-9 in hypoxic nasopharyngeal carcinoma cells and its correlation with cell proliferation and apoptosis

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