Clinical Significance of Genetic Variants in Colon Cancer

Nakashidze, Irina; Petrović, Nina; Kedelidze, Nino; Dariya, Begum

doi:10.1007/978-3-030-72702-4_4

Cited by 2 publications

(2 citation statements)

References 111 publications

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“…Studies suggest that genes' SNPs, including the VDR gene SNP, are associated with numerous conditions (20)(21)(22)(23). Research has revealed a correlation between serum vitamin D levels and the manifestation of AITDs.…”

Section: O N L I N E F I R S Tmentioning

confidence: 99%

Vitamin D levels and VDR rs2228570 genetic variant in Autoimmune Thyroiditis

Shaikh,

Nakashidze

2023

Sanamed

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Autoimmune Thyroiditis (AIT) is a prevalent autoimmune disorder characterized by an immune response targeting the thyroid gland. Genetic factors play a significant role in AIT susceptibility, with immune-related genes, especially the vitamin D receptor (VDR) gene, potentially influencing AIT development. This comprehensive review delves into the intricate association between VDR gene polymorphisms, particularly rs2228570 (FokI), and AIT susceptibility, exploring various populations. Research has unveiled contrasting outcomes regarding the link between the VDR rs2228570 polymorphism and AIT risk across diverse ethnic groups. Certain populations have exhibited a noteworthy correlation, suggesting that population-specific genetic factors contribute to AIT risk. A recurring observation of vitamin D deficiency in AIT patients has correlated with elevated anti-thyroid antibodies, abnormal thyroid function, and thyroid volume. The results emphasize the possible role of vitamin D in the development of AIT, suggesting the importance of vitamin D supplementation to address deficiencies associated with AIT. In addition to VDR rs2228570, other genetic variants have also shown associations with AIT susceptibility, displaying varying results across different populations. Ethnicity emerges as a pivotal factor influencing these associations, underscoring the need to consider genetic variations in diverse populations. We emphasize the intricate interplay between VDR gene polymorphisms, vitamin D, and AIT susceptibility. Extensive research is essential to unveil the clinical significance of these genetic variations, offering prospects for enhanced diagnostic and therapeutic strategies for individuals with AIT.

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Section: O N L I N E F I R S Tmentioning

confidence: 99%

Vitamin D levels and VDR rs2228570 genetic variant in Autoimmune Thyroiditis

Shaikh,

Nakashidze

2023

Sanamed

Self Cite

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“…In general, oncological diseases are linked to numerous causative factors, including hormonal imbalance, the alteration of some cliniclaboratory characteristics genetics and environmental factors [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Altered Gene Expression and Epigenetic Mechanisms in Breast Cancer

Parveen Shaikh,

Murvanidze,

Shaikh

et al. 2023

J Biomed Res Environ Sci

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Among oncological diseases of women, breast cancer is a widespread disease. It should be noted that the disease is heterogeneous in many clinical and pathological features. The development of breast cancer is associated with many factors, and it is difficult to identify any specific risk factor. The studying the expression and epigenetic mechanisms of genes associated with breast cancer, it is possible to effectively combine epigenetic therapy with the existing one in clinical practice (chemotherapy, hormonal therapy, etc.) and accordingly, the treatment of disease is significantly improved.

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Clinical Significance of Genetic Variants in Colon Cancer

Cited by 2 publications

References 111 publications

Vitamin D levels and VDR rs2228570 genetic variant in Autoimmune Thyroiditis

Vitamin D levels and VDR rs2228570 genetic variant in Autoimmune Thyroiditis

The Altered Gene Expression and Epigenetic Mechanisms in Breast Cancer

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