Clinical Significance of Forced Oscillation Technique for Evaluation of Small Airway Disease in Interstitial Lung Diseases

Mikamo, Masashi; Fujisawa, Tomoyuki; Oyama, Yoshiyuki; Kono, Masato; Enomoto, Noriyuki; Inui, Naoki; Sumikawa, Hiromitsu; Johkoh, Takeshi; Suda, Takafumi

doi:10.1007/s00408-016-9949-1

Cited by 20 publications

(14 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…58,59 In a study by Mori et al, 60 decreased X values (especially X5) were found in patients with ILD, mostly in inspiration, which has more negativity than in expiration, in contrast to patients with COPD, which had decreased values in expiration that is more negative than in inspiration. A Japanese study conducted by Mikamo et al 61 showed that oscillometry may be a useful tool in assessment of small airways disease in interstitial lung disease. A very recent study, conducted by Reham et al, 62 studied correlations between oscillometry and spirometry on patients diagnosed with rheumathoid arthritis accociating ILD, and concluded that IOS can be used as an early screening technique to identify proximal and distal pulmonary tissue affection even before spirometry changes appear.…”

Section: Interstitial Lung Disease (Ild)mentioning

confidence: 99%

Lung Function Assessment by Impulse Oscillometry in Adults

Porojan-Suppini¹,

Fira-Mlădinescu²,

Marc³

et al. 2020

TCRM

View full text Add to dashboard Cite

Over the past decades, impulse oscillometry (IOS) has gained ground in the battery of pulmonary function tests. Performing the test requires minimal cooperation of the patient; therefore, it is a useful tool, especially in evaluating lung mechanics in children, elderly patients, and those who cannot perform spirometry. Oscillometry has also been used in both clinical and research departments. Studies were published mainly in asthma regarding detection of bronchodilator response and the therapeutic response to different drugs. Furthermore, it has been shown to be a sensitive technique to evaluate disease control. Other studied diseases were COPD, interstitial lung diseases, small airway disease, impairment of lung function due to exposure to occupational hazards or smoking, central airways obstruction, cystic fibrosis, monitoring lung mechanics during mechanical ventilation and sleep, neuromuscular diseases, lung transplant, and graft function. The aim of this review is to present the utility of oscillometry on the previously mentioned clinical fields.

show abstract

Section: Interstitial Lung Disease (Ild)mentioning

confidence: 99%

Lung Function Assessment by Impulse Oscillometry in Adults

Porojan-Suppini¹,

Fira-Mlădinescu²,

Marc³

et al. 2020

TCRM

View full text Add to dashboard Cite

show abstract

“…If the small airway lesion is present, the resistance is increased and more negative shift of reactance at low frequency, and the interstitial changes cannot be reflected. Mikamo et al28 reported that the 90 patients with ILD were divided into the two groups according to the presence or absence of small airway disease findings detected by HRCT, and the impedance parameters were compared. The absolute values of R5–R20, X5, and ƒres were elevated in ILD patients with small airway disease compared to those without small airway disease.…”

Section: Discussionmentioning

confidence: 99%

Comparison of impedance measured by the forced oscillation technique and pulmonary functions, including static lung compliance, in obstructive and interstitial lung disease

Takeichi¹,

Yamazaki²

2019

COPD

View full text Add to dashboard Cite

Objective: To examine whether the parameters of impedance measured by the broadband frequency forced oscillation technique (FOT) were reflected by changes in lung compliance induced by emphysema and fibrosis, we retrospectively compared the parameters of FOT and pulmonary functions, including static lung compliance (Cst), in obstructive lung disease (OLD) and interstitial lung disease (ILD). Patients and methods: The data of 18 patients with OLD (16 with COPD, two with asthma COPD overlap), 11 with ILD, and 24 healthy volunteers, whose respiratory impedance was measured using a MostGraph-01 and other pulmonary functions including Cst and lung resistance (R L ) were measured on the same day and were retrospectively collected and compared. Results: The parameters of resistance, reactance, and resonant frequency showed good correlations with ventilation unevenness ( r =0.63, −0.89, 0.77, respectively) and lung elastic resistance ( r =0.59, −0.80, 0.73, respectively) in all groups (N=53). These indices were significant determinants of increased respiratory resistance and more negative shift of respiratory reactance (Xrs) at lower frequency ( P <0.001). Decreased functional residual capacity was also a determinant of Xrs at 5 Hz (X5) ( P <0.05). The differences in mean X5 in the expiratory phase relative to those in the inspiratory phase (within-breath changes in X5) were associated with airflow obstruction ( P <0.002) and lung elastic resistance ( P <0.001). However, no significant correlations between Cst and any parameters of respiratory impedance were observed. Conclusions: These findings suggest that the impedance parameters measured by FOT are reflected by airway obstruction, ventilation unevenness, and lung resistance, but hardly reflected by changes in lung compliance due to emphysema or fibrosis in both CLD and ILD.

show abstract

“…Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive, fibrosing interstitial pneumonia of unknown cause with a poor prognosis [1][2][3]. Since the clinical course of individual patients with IPF varies [4], many studies have been reported regarding developing clinical, physiological, and radiological markers to evaluate the clinical conditions and prognosis of patients with IPF [5][6][7][8][9][10][11][12][13][14][15][16][17]. As radiological and physiological markers, fibrosis-related high-resolution computed tomography (HRCT) findings and pulmonary function tests are used for predicting the prognosis of patients with IPF [10,11,13,16,17].…”

Section: Introductionmentioning

confidence: 99%

“…In addition to these markers, studies for evaluating patients with IPF using oscillometry, also called the forced oscillation technique, have been reported [14,15].…”

Section: Introductionmentioning

confidence: 99%

Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis

et al. 2020

View full text Add to dashboard Cite

Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects the disease severity. In addition, traction bronchiectasis has been considered to reduce respiratory resistance and correlate negatively with airflow obstruction, but this hypothesis has not been validated. The present study aimed to investigate the correlations between oscillometric parameters and fibrosis-related lung abnormalities in IPF and to assess the utility of oscillometry as a surrogate marker for traction bronchiectasis and airflow obstruction.Eighty Japanese patients with IPF underwent high-resolution computed tomography (HRCT), spirometry, and oscillometry and were retrospectively investigated. Fibrosis-related HRCT findings were scored regarding airspace consolidation, honeycombing, architectural distortion, traction bronchiectasis, and fibrosis. Correlations between the HRCT scores, spirometric parameters, and oscillometric parameters were analysed.Respiratory reactance correlated positively with all fibrosis-related HRCT scores. Vital capacity and forced vital capacity (FVC) correlated negatively with oscillometric parameters and HRCT scores, reflecting the severity of restrictive ventilatory deficiency. Respiratory resistance was not related to any of the HRCT scores or forced expiration volume in 1 s/FVC. However, forced expiration volume in 1 s/FVC correlated positively with HRCT scores, which showed that airflow obstruction became milder as the disease progressed.In conclusion, respiratory reactance reflects fibrosis and restrictive ventilatory deficiency in IPF. Moreover, respiratory resistance is independent of traction bronchiectasis and airflow obstruction in patients with IPF, which implies that respiratory resistance might reflect different properties of the airways.

show abstract

Clinical Significance of Forced Oscillation Technique for Evaluation of Small Airway Disease in Interstitial Lung Diseases

Abstract: UMIN 000020733.

Cited by 20 publications

References 28 publications

<p>Lung Function Assessment by Impulse Oscillometry in Adults</p>

<p>Lung Function Assessment by Impulse Oscillometry in Adults</p>

<p>Comparison of impedance measured by the forced oscillation technique and pulmonary functions, including static lung compliance, in obstructive and interstitial lung disease</p>

Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis

Contact Info

Product

Resources

About