Clinical Significance of Flow Cytometric Analysis of DNA Content in Colorectal Carcinoma.

Tsujita, Kazunori; Funahashi, Kimihiko; Watanabe, Masashi; Nakamura, Hiroshi; Watanabe, Kiyoshi; Tokura, Natsuki; Nagasawa, Yasushige; Ogai, Tadahisa; Kobayashi, Kazuo; Yanagita, K.; Kuramoto, S; Terada, Yoshio; Tsujimoto, Shiro

doi:10.5833/jjgs.24.2176

Cited by 3 publications

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“…There have been many studies on the relationship between tumor ploidy and prognosis in colorectal cancer. Most of them have shown a survival advantage for patients with diploid tumors compared with aneuploid tumors [2- 7,9,10], although some authors have found no such advantage [ 1,111. Regarding the relationship between DNA ploidy and prognosis with respect to stage, Kouri et al [9] found that for patients with Dukes' stages A-C, there was a significant difference in the disease-free survival between aneuploid, tetraploid, and diploid tumors, either as a group or when stratified by stage. In addition, Armitage et al [ 101 found that the recurrence rate was significantly higher for patients with aneuploid tumors compared with those with diploid tumors, especially in patients with Dukes' stage B disease.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the relationship between DI and prognosis, some reports [7,17] have shown that DI correlated with prognosis among the patients with aneuploid tumors, although other studies [5, 9,18] have failed to find such a relationship.…”

Section: Discussionmentioning

confidence: 99%

“…The prognostic significance of DNA ploidy has been investigated both retrospectively [ 1,4,6] and prospectively [3,5,9,10]. Many previous reports have shown a survival advantage for patients with diploid tumors [2][3][4][5][6][7]9,10], although some studies failed to find such an advantage [ 1 , l l 1. Several authors have shown that DNA ploidy is a significant independent predictor of patient survival [2,4,6], but this point is still controversial [5,121. In this study we measured the tumor DNA content by flow cytometry using frozen samples obtained from patients who had undergone a curative resection for colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of flow cytometric analysis of DNA content in colorectal cancer: A prospective study

Tomoda

Kakeji

Furusawa

1993

Journal of Surgical Oncology

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We prospectively analyzed the tumor DNA content by flow cytometry in 100 patients who underwent a curative resection for colorectal cancer between August 1989 and May 1992 in order to evaluate the prognostic significance of DNA ploidy and the DNA index (DI). Patients with aneuploid tumors were found to have a significantly shorter disease-free survival than those with diploid tumors (P = 0.014). In addition, patients who had tumors with a DI greater than 1.6 had a significantly shorter disease-free survival than those who had tumors with a DI of less than 1.6 (P = 0.0001). After stratification by stage, this association was only seen in Dukes' stage C disease (P = 0.0065). Cox's regression analysis demonstrated that the DI (below or above 1.6) rather than DNA ploidy was an important independent predictor of disease-free survival. These results suggest that the DI rather than DNA ploidy provides us with important prognostic information in patients undergoing curative surgery for colorectal cancer. 0 1993 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of flow cytometric analysis of DNA content in colorectal cancer: A prospective study

Tomoda

Kakeji

Furusawa

1993

Journal of Surgical Oncology

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DNA index as a significant predictor of recurrence in colorectal cancer

Tomoda

Baba

Saito³

et al. 1998

Diseases of the Colon &Amp; Rectum

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DNA index as a significant indicator of lymph node metastasis and local recurrence of rectal cancer

Kimura¹,

Kijima²,

Moriwaki³

et al. 1992

Diseases of the Colon &Amp; Rectum

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To confirm the prognostic significance of the DNA index (DI) in cases of rectal cancer, the nuclear DNA content of tumor cells was examined in 184 cases of rectal cancer treated with curative surgery, and the incidence of lymph node metastasis and recurrence of the cancer was analyzed. The incidence of lymph node metastasis was 43.9 percent in cases with aneuploidy (DI above 1.5), being statistically different from the 18.0 percent incidence in cases with diploidy (P < 0.001). Although the extent of lymph node metastasis was limited to adjacent lymph nodes in cases with diploidy, distant lymph node metastases were frequent in cases with aneuploidy, especially in those with a DI above 1.5. Furthermore, the incidence of recurrence of cancer, and especially of local recurrence, was significantly higher (P < 0.001) in cases with aneuploidy (DI above 1.5) than in cases with diploidy and aneuploidy (DI below 1.4). These findings indicate the significant value of the DNA index for the prediction of lymph node metastasis and local recurrence in patients with rectal cancer.

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Clinical Significance of Flow Cytometric Analysis of DNA Content in Colorectal Carcinoma.

Cited by 3 publications

References 0 publications

Prognostic significance of flow cytometric analysis of DNA content in colorectal cancer: A prospective study

Prognostic significance of flow cytometric analysis of DNA content in colorectal cancer: A prospective study

DNA index as a significant predictor of recurrence in colorectal cancer

DNA index as a significant indicator of lymph node metastasis and local recurrence of rectal cancer

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