Clinical significance of epithelial–mesenchymal transition-related markers expression in the micrometastatic sentinel lymph node of NSCLC

Lafuente-Sanchis, Aranzazu; Olmo, A. Gutiérrez del; Carretero, Julián; Fernández-Coronado, Javier Alcácer; Estors-Guerrero, Miriam; Martínez-Hernández, Néstor J.; Cremades, Antonio; Zúñiga, Ángel; Alcácer, Javier; Farràs, Rosa; Cuenca, María Josep; Galbis-Caravajal, José M.

doi:10.1007/s12094-019-02138-3

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…There was also a relationship between lymphangiogenesis, micrometastasis and adhesion molecules with specific histology (E- Cadherin, α/β/γ- Catenin) [ 123 ]. Transcription factors of EMT, SNAI2 and TWIST1, were also involved in lymph node progression, dependent on the TGF-β pathway partly [ 124 , 125 ].…”

Section: Migration and Distant Metastatic Of Nsclc Cellsmentioning

confidence: 99%

Advances in lymphatic metastasis of non-small cell lung cancer

Zhang,

Ma,

Xue

et al. 2024

Cell Commun Signal

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Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis and treatment technology, abundant patients with lung cancer are still inevitably faced with recurrence and metastasis, contributing to death. Lymphatic metastasis is the first step of distant metastasis and an important prognostic indicator of non-small cell lung cancer. Tumor-induced lymphangiogenesis is involved in the construction of the tumor microenvironment, except promoting malignant proliferation and metastasis of tumor cells, it also plays a crucial role in individual response to treatment, especially immunotherapy. Thus, this article reviews the current research status of lymphatic metastasis in non-small cell lung cancer, in order to provide some insights for the basic research and clinical and translational application in this field.

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Section: Migration and Distant Metastatic Of Nsclc Cellsmentioning

confidence: 99%

Advances in lymphatic metastasis of non-small cell lung cancer

Zhang,

Ma,

Xue

et al. 2024

Cell Commun Signal

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“…IHC is a widespread method for detecting lymph node micrometastases based on antigen-antibody responders and a low CDH1/CDH2 ratio has recently been shown to be associated with lung cancer micrometastases [64].…”

Section: Future Perspectivementioning

confidence: 99%

The Role of Lymphadenectomy in Early-Stage NSCLC

Manfredini

Zirafa

Filosso

et al. 2023

Cancers

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Lung cancer remains the leading cause of cancer-related death worldwide. The involvement of lymph nodes by the tumor has a strong impact on survival of patients. For this reason, lymphadenectomy plays a crucial role in the staging and prognosis of NSCLC, to define the most appropriate therapeutic strategies concerning the stage of the disease. To date, the benefit, in terms of survival, of the different extents of lymphadenectomy remains controversial in the scientific community. It is recognized that metastatic involvement of mediastinal lymph nodes in lung cancer is one of the most significant prognostic factors, in terms of survival, and it is therefore mandatory to identify patients with lymph node metastases who may benefit from adjuvant therapies, to prevent distant disease and local recurrences. The purpose of this review is to evaluate the role of lymphadenectomy in early-stage NSCLC in terms of efficacy and accuracy, comparing systematic, sampling, and lobe-specific lymph node dissection and analyzing the existing critical issue, through a search of the most relevant articles published in the last decades.

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“…Как следствие, адекватное определение распространенности злокачественного процесса играет важную роль в выборе методов лечения онкологических больных [1][2][3][4]. На сегодняшний день статус сторожевого лимфатического узла (СЛУ) считается одним из важных прогностических факторов метастазирования некоторых опухолей [5][6][7][8]. Сторожевым (сигнальным) лимфатическим узлом считается лимфоузел, находящийся на пути прямого лимфатического оттока от первичного опухолевого узла.…”

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Diagnosis of sentinel lymph nodes in patients with cancer of the larynx and laryngopharynx using a new radiopharmaceutical based on technetium-99m-labeled gamma aluminum oxide

et al. 2023

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Аim. To study the possibility of using a radiopharmaceutical based on aluminum oxide labeled with 99mТс ([99mТс]-Al2O3) for the diagnosis of sentinel lymph nodes (SLN) in tumors of the larynx and laryngopharynx in comparison with a phytate colloid ([99mTc]-phytate colloid).Materials and methods. The study included patients with cancer of the larynx and laryngopharynx (T2–4N0M0) (n = 54). In the prospective group (n = 30), [99mТс]-Al2O3 was used as a radiopharmaceutical, in the retrospective group (n = 24), [99mТс]-phytate colloid was used. All radiopharmaceuticals were introduced endoscopically into the submucosal space along the periphery of the tumor. After 18 hours, single-photon emission computed tomography (SPECT) and intraoperative SLN detection were performed.Results. In the retrospective group, SLNs were detected in 20 out of 24 patients. A total of 32 lymph nodes were identified in the retrospective group. The median number of detected lymph nodes in one patient was 1.3 [0–3], the intensity of the radiopharmaceutical uptake on scintigrams was 2.2 [0.7–8.1], intraoperatively – 4 [1.6–9.0]. In the prospective group, [99mTc]-Al2O3 uptake in the lymph nodes of the neck was determined in 27 patients (90%); in3 patients, SLNs were not visualized. A total of 57 lymph nodes were identified (in 27 patients). The median number of visualized SLNs was 1.5 [0–5], the intensity of [99mТс]-Al2O3 uptake according to SPECT and intraoperative detection was 4.8 [0.7–19.4] and 6 [1.1–22.0], respectively.Conclusion. The most significant advantage of using [99mТс]-Al2O3 as a radiopharmaceutical is its high uptake in SLNs, which leads to an increase in the sensitivity of the method as a whole up to 90 versus 83% when using [99mTc]-phytate colloid.

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Clinical significance of epithelial–mesenchymal transition-related markers expression in the micrometastatic sentinel lymph node of NSCLC

Cited by 7 publications

References 31 publications

Advances in lymphatic metastasis of non-small cell lung cancer

Advances in lymphatic metastasis of non-small cell lung cancer

The Role of Lymphadenectomy in Early-Stage NSCLC

Diagnosis of sentinel lymph nodes in patients with cancer of the larynx and laryngopharynx using a new radiopharmaceutical based on technetium-99m-labeled gamma aluminum oxide

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