Clinical significance of DNA ploidy and S-phase fraction and their relation to p53 protein, c-erbB-2 protein and HCG in operable muscle-invasive bladder cancer

Fosså, Sophie D.; Berner, A.; Jacobsen, A. B.; Wæhre, Håkon; Kvarstein, Bernt; Urnes, Thomas; Ogreid, P; Johansen, Truls E. Bjerklund; Silde, J.; Nesland, Jahn M.

doi:10.1038/bjc.1993.388

Cited by 18 publications

(3 citation statements)

References 44 publications

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“…Many previous studies have investigated the role of histological grade and of proliferative activity in bladder cancer. While the results of these studies unanimously suggest that proliferative activity and histological grade increase with tumour stage, there are discordant results with respect to the clinical significance of these parameters12–16. Most authors have observed significant associations between histological grade and clinical outcome17, 18 but some could not find a link between high histological grade and poor prognosis among bladder cancer patients in subgroups of tumours of one stage19–21.…”

Section: Discussionmentioning

confidence: 99%

Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade

et al. 2001

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The number of genes suggested to play a role in cancer biology is rapidly increasing. To be able to test a large number of molecular parameters in sufficiently large series of primary tumours, a tissue microarray (TMA) approach has been developed where samples from up to 1000 tumours can be simultaneously analysed on one glass slide. Because of the small size of the individual arrayed tissue samples (diameter 0.6 mm), the question arises of whether these specimens are representative of their donor tumours. To investigate how representative are the results obtained on TMAs, a set of 2317 bladder tumours that had been previously analysed for histological grade and Ki67 labelling index (LI) was used to construct four replica TMAs from different areas of each tumour. Clinical follow-up information was available from 1092 patients. The histological grade and the Ki67 LI were determined for every arrayed tumour sample (4x2317 analyses each). Despite discrepancies in individual cases, the grade and Ki67 information obtained on minute arrayed samples were highly similar to the data obtained on large sections (p<0.0001). Most importantly, every individual association between grade or Ki67 LI and tumour stage or prognosis (recurrence, progression, tumour-specific survival) that was observed in large section analysis could be fully reproduced on all four replica TMAs. These results show that intra-tumour heterogeneity does not significantly affect the ability to detect clinico-pathological correlations on TMAs, probably because of the large number of tumours that can be included in TMA studies. TMAs are a powerful tool for rapid identification of the biological or clinical significance of molecular alterations in bladder cancer and other tumour types.

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Section: Discussionmentioning

confidence: 99%

Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade

et al. 2001

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“…These studies report HER2 expression rates ranging from 2–74% (Table 3). 57–74 This variation in expression between the different studies is in part due to the differences in methodologies used to assess HER2 and variability in the reporting of data. Both overexpression without gene amplification and heterogeneity in HER2 expression are more common in bladder cancer than in breast cancer 57, 63, 67–68, 70.…”

Section: Salvage Therapymentioning

confidence: 99%

Overview of bladder cancer trials in the Cancer and Leukemia Group B

Small

Halabi

Dalbagni

et al. 2003

Cancer

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“…In addition to its undisputed role in tumorigenesis, p53 also has prognostic value in terms of response to therapy since most triggers of apoptosis induce and may require p53. From a clinical standpoint, mutations in p53 are usually a poor prognostic indication in a variety of tumor types including gastrointestinal, hematopoietic, breast, and genito-urinary cancers (152,(265)(266)(267)(268)(269)(270)(271)(272)(273)(274)(275)(276)(277).…”

Section: Antineoplastic Therapiesmentioning

confidence: 99%

Apoptosis in tumorigenesis and cancer therapy

McGill

Fisher²

1997

Front Biosci

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Introduction 3. The biochemistry of apoptosis 3.1 The executioner and its substrates 3.2 Channeling our attention on the Bcl-2 family 3.3 The Fas way to apoptosis 3.4 The PI3-K/Akt survival pathway 4. Apoptosis and cancer 4.1 Apoptosis and tumorigenesis 4.2 Anoikis and anchorage-independence: implications for tumor metastasis 4.3 Hypoxia and angiogenesis 4.4 Antineoplastic therapies 5. Conclusions 6. Acknowledgments 7. References

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Clinical significance of DNA ploidy and S-phase fraction and their relation to p53 protein, c-erbB-2 protein and HCG in operable muscle-invasive bladder cancer

Cited by 18 publications

References 44 publications

Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade

Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade

Overview of bladder cancer trials in the Cancer and Leukemia Group B

Apoptosis in tumorigenesis and cancer therapy

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