Clinical significance of diurnal variation in the estimation of plasma zinc

McMillan, Euan M.; Rowe, David J.

doi:10.1111/j.1365-2230.1982.tb02488.x

Cited by 27 publications

(17 citation statements)

References 6 publications

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“…5 Other studies have shown that the meal's content and even its consistency may affect zinc concentrations. 8,12 The mean value for plasma copper concentration was significantly lower at noon as compared with the morning and afternoon values (Fig. 2).…”

Section: Discussionmentioning

confidence: 99%

“…It has been accepted for more than 30 years that in other species there is a significant diurnal variation in plasma zinc concentrations. 4,6,8,12,20,21 The effect of meals on the plasma zinc concentration is inconclusive. Some studies state that ingesting a meal has no effect on daily zinc concentration fluctuations.…”

Section: Discussionmentioning

confidence: 99%

“…14,15 In several studies in other species, plasma zinc concentrations fluctuated as much as 25-33% and the authors concluded that to compare zinc concentrations among individuals or populations, it is necessary to standardize the sampling time. 6,8,12 Perhaps this should be considered in avian medicine, given the controversy concerning what constitutes elevated and potentially toxic plasma zinc concentrations. 14,15 Previous studies designed to determine zinc reference ranges do not report whether the birds were sampled at various times during the day.…”

Section: Discussionmentioning

confidence: 99%

“…Reference range studies in other species have shown that there is a diurnal variation of whole blood, plasma, and serum zinc concentrations. 1,[4][5][6]8,12,20 A question was, is there a significant diurnal variation in the zinc concentration in psittacine birds and could such variation lead to a misdiagnosis? Because studies in other species have shown that other elements exhibit a diurnal variation, the authors examined 13 other plasma elements.…”

Section: Introductionmentioning

confidence: 99%

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Psittacine Plasma Concentrations of Elements: Daily Fluctuations and Clinical Implications

et al. 2005

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Abstract. During the past 2 decades, the potential for excessive exposure of pet birds to zinc has become a concern for many pet bird owners. Ideally, avian zinc toxicosis is diagnosed on the basis of history of exposure to zinc, radiographic evidence of ingested metal, occurrence of melena, detection of an elevated plasma zinc concentration, and response to treatment. However, most pet birds suspected of having zinc toxicosis present with vague signs and lack of radiographic evidence; therefore, the diagnosis relies on the presence of an elevated plasma zinc concentration. A question was, is there a significant diurnal variation in the zinc concentration in psittacine birds and could this be clinically relevant? Because studies in other species have shown that zinc is not the only element that shows a diurnal variation, the authors examined 13 other plasma elements including arsenic, cadmium, calcium, cobalt, copper, iodine, iron, magnesium, manganese, molybdenum, potassium, selenium, and total phosphorus. Fifteen adult psittacine birds housed in the same aviary were used in this study. Three blood samples, separated by 4 hours, were taken from the right jugular vein in each bird. All elements were measured in plasma. Zinc, copper, and molybdenum revealed diurnal fluctuations. The results of this study suggest that interpretation of clinical samples may be more complicated than previously believed. Furthermore, on the basis of the results of this study, it is possible that some avian reference ranges may need to be reexamined.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psittacine Plasma Concentrations of Elements: Daily Fluctuations and Clinical Implications

et al. 2005

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“…However, the present blood sampling was conducted early in the morning after an overnight fast, while it was done in the afternoon in the previous study. Diurnal variation in plasma or serum Zn levels has been no ticed (9)(10)(11), and P-Zn levels in the afternoon sample were about 10-20% less than in the early morning sample in our own study of subjects on an ordinary meal schedule (12). Therefore, the present P-Zn level after rectification of diurnal variation may be comparable with the previous level in female students on the average, but there remain a few female students with remarkably low values.…”

Section: Discussionmentioning

confidence: 99%

Minerals in plasma and urine and gustatory function tests for salt in a group of healthy young men.

Suzuki

Ishida

Suzuki

et al. 1987

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryDetection threshold for salt (NaCl) and discrimination between two levels of NaCl concentration (0.6 and 0.7%) in foods, and their relation to some selected biochemical parameters in plasma and urine (Zn, Na, K, Mg, Ca, Se for plasma and urine, Cu and retinol binding protein for plasma) were investigated in 15 healthy male college students. No subject failed to discriminate the NaCl concentrations in more than 50% of the tests. The rate of correct discrimination (RCD) was not associated with plasma Zn (P-Zn), plasma retinol binding protein (P RBP), urinary potassium (U-K) or urinary sodium (U-Na), which signif icantly correlated with RCD in our previous study, while the detection threshold was significantly correlated with urinary Ca-Mg ratio (U -Ca/Mg), urinary Ca (U-Ca), U-Na, and urinary Mg. In the stepwise multiple regression analysis, U-Ca/Mg, plasma Ca, plasma Na, and RCD were selected as significant independent variables. These indicate that the status of minerals such as Na, Ca, and Mg is related to the gustatory function. One possible explanation for the discrepancy between the present and previous results is the elevated P-Zn and P-RBP levels in the present subjects.

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