Clinical significance of coated extracorporeal circuits: a review of novel technologies

Günaydın, Serdar

doi:10.1191/0267659104pf718oa

Cited by 26 publications

(20 citation statements)

References 20 publications

(20 reference statements)

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“…Studies with similar objectives and methods have often yielded contradictory results, which suggest that the specific response mechanisms of CPB may vary between patients [23].…”

Section: Resultsmentioning

confidence: 99%

Strategic Leukofiltration in Cardiac Surgery

Günaydın

McCusker²,

Vijay

2005

CMCCHA

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Systemic inflammatory response syndrome (SIRS) with activation of molecular cascades, cell activation, accumulation of interstitial fluid, organ dysfunction and, occasionally, organ failure is still a commonly recognized consequence of cardiac surgery. SIRS leads to costly complications and several strategies intended to ameliorate the symptoms that have been studied, including leukocyte reduction, using filtration. Although, the body of work suggests that leukoreduction attenuates SIRS, discrepancies remain within the literature. The recent literature is reviewed highlighting the areas where concordance is lacking. In our study, on the basis of indirect indicators of SIRS, platelet function by thromboelastography biomaterial evaluation by light and scanning electron microscopy, we present our conclusions regarding clinical outcomes and the role of leukofiltration.

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“…Studies with similar objectives and methods have often yielded contradictory results, which suggest that the specific response mechanisms of CPB may vary between patients [23].…”

Section: Resultsmentioning

confidence: 99%

Strategic Leukofiltration in Cardiac Surgery

Günaydın

McCusker²,

Vijay

2005

CMCCHA

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“…In the literature, there are several reports on the impact of coated oxygenators on the immune response. It was suggested that leukocyte levels increased and platelet levels decreased in both phosphorylcholine-coated and uncoated oxygenators with regard to baseline values during induction of anaesthesia 8,9…”

Section: Discussionmentioning

confidence: 99%

Humoral immune response and coated or uncoated oxygenators during cardiopulmonary bypass surgery

Karakişi

Kunt

Bozok

et al. 2016

CVJA

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SummaryAim:To investigate and compare uncoated and phosphorylcholine-coated oxygenators in terms of induction of humoral immune response during coronary artery bypass surgery.Methods:A total of 20 consecutive patients who underwent coronary artery bypass surgery were randomly distributed into two groups according to the type of oxygenator used during surgery. Group 1 consisted of 10 patients who were operated on using phosphorylcholine-coated oxygenators. Group 2 contained 10 patients who underwent surgery using uncoated oxygenators. Blood and oxygenator fibre samples were obtained and compared in terms of immunoglobulins (IgG, IgM), complements (C3c, C4), serum total protein and albumin levels using electron microscopy and flow cytometry.Results:In group 1, levels of IgM, IgG, total protein and serum albumin were significantly increased at the end of cardiopulmonary bypass (CPB) compared to those at the beginning of CPB. In group 2, C3c and C4 levels at the beginning of CPB were found to be significantly higher than at the end. Electron microscopic examination of oxygenator fibres demonstrated that phosphorylcholine-coated fibres were less likely to be adsorbed by serum proteins and complements than the uncoated fibres.Conclusion:Our results indicate that phosphorylcholine-coated oxygenators seemed to induce humoral immune response to a lesser extent than uncoated oxygenators during coronary artery bypass procedures.

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“…20 Despite early promise as a means of reducing the inflammatory response to surgery and subsequent organ damage, the evidence of the clinical value of leukocyte filtration remains equivocal. 21 One of the limitations affecting almost all studies investigating the inflammatory response to CPB is that the patient populations are small and include uncomplicated cases.…”

Section: Discussionmentioning

confidence: 99%