Clinical significance of coagulase-negative staphylococci isolated from neonates

Cunha, Maria de Lourdes; Lopes, C. A.; Rugolo, Lígia M. S. S.; Silveira, Liciana Vaz de Arruda

doi:10.2223/jped.861

Cited by 14 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that 65% of our patients with repeated isolates were treated with antibiotics, and glycopeptides (vancomycin and teicoplanin) were the most commonly used and accounted for 60% of cases. This result was in keeping with a study by Senger et al in 2007, which reported widespread misuse of glycopeptides in the treatment of CoNS bacteraemia [11]. Vancomycin therapy was as likely to be administered for episodes classified as contaminants as for those classified as bacteraemia [4].…”

Section: Discussionsupporting

confidence: 87%

“…A study was conducted to determine the clinical significance of CoNS isolated from neonates and found S. epidermidis was the major species isolated from 46 infants (85.2%). S. haemolyticus was responsible for infection in two infants (3.7%), S. lugdunensis in three infants (5.6%), and S. simulans (1.8%), S. warneri (1.8%) and S. xylosus (1.8%) in one infant each [11]. In 2007, Senger et al also demonstrated a high percentage of S. epidermidis isolated in their study, which surprisingly contributed to 68% of the total CoNS isolates [12].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The significance of coagulase-negative staphylococci bacteremia in a low resource setting

Rahman

Hamzah

Hassan

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Coagulase-negative staphylococci (CoNS) are a group of micro-organisms that are increasingly implicated as a cause of significant infection and the leading cause of bloodstream infection (BSI). One important predictor of true BSI is the isolation of CoNS from multiple blood cultures, presuming that the isolates represent the same species. Thus the objective of this study was to determine the significance of repeated CoNS isolated from blood cultures. Methodology: This was a prospective laboratory study which was initiated in June 2007 and lasted until July 2008. CoNS isolates were obtained from patients who had two positive blood cultures within a 14-day interval. CoNS were identified to the species level using an APIStaph, and antibiotics susceptibility testing was performed according to Clinical and Laboratory Standards Institute specifications. Strain relatedness was confirmed using pulsed-field gel electrophoresis. Results: During the study period, 202 CoNS-positive samples were isolated from 101 patients. The most common species isolated was Staphylococcus epidermidis (59.0%), and 83.2% of the patients isolated the same species of CoNS from repeated blood cultures. Among the isolates of the same species, only 40.7% had the same antibiogram. CoNS with the same species and antibiogram had 93.3% probability of belonging to the same strain. Most (65.5%) of the patients were treated with antibiotics, primarily from the glycopeptides group. Conclusion: Speciation and antibiogram of CoNS from repeated blood cultures are adequate in determining the significance of repeated CoNS isolated from blood cultures.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

The significance of coagulase-negative staphylococci bacteremia in a low resource setting

Rahman

Hamzah

Hassan

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Once formed, these biofilms render the cells less accessible to the defense system of the organism, thus impairing the action of antibiotics and, in turn, represents basic survival strategies of these microorganisms, a fact that explains why biofilms are considered to be of great importance for public health. Therefore, studies and diagnostic methods identifying virulent bacterial strains, i.e., strains with a capacity for slime production and consequent biofilm formation, are necessary to develop effective strategies for biofilm control and improvement of patient care (3,5,6,9,13,22,25,27,56,68).…”

Section: Introductionmentioning

confidence: 99%

Bacterial biofilms with emphasis on coagulase-negative staphylococci

Oliveira¹,

Cunha²

2008

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

In addition to their capacity to attach to surfaces, various groups of microorganisms also produce an extracellular polymeric substance known as "slime". This slime forms a thin layer around cells known as biofilm. Thus, biofilm structure comprises bacterial cells and an extracellular polymeric substance. It also presents a defined architecture, providing the microorganisms with an excellent protective environment and favoring the exchange of genetic material between cells as well as intercellular communication. The ability to produce biofilm is observed in a large group of bacteria, including coagulase-negative staphylococci (CNS) which are the predominant microorganisms of normal skin flora and have been implicated as the causative agents of hospital infections. Bacteremia caused by these agents is common in immunodepressed persons, in patients with cancer, in adult and neonatal intensive care units (ICU) and in patients using catheters or other prosthetic devices. The pathogenicity of CNS infections is probably related to the production of slime, which adheres preferentially to plastic and smooth surfaces, forming a biofilm that protects against attacks from the immune system and against antibiotic treatment, a fact hindering the eradication of these infections. The main objective of the present review was to describe basic and genetic aspects of biofilm formation and methods for its detection, with emphasis on biofilm creation by CNS and its relationship with diseases caused by these microorganisms which are becoming increasingly more frequent in the hospital environment.

show abstract

“…These bacteria are of little virulence [55] but are frequently implicated as the cause of infections in patients who are immunocompromised or have medical implants [56] [57] [58] [59]. A high prevalence of CNS on telephones is consistent with Cozanitis et al in their finding of CNS on all the telephones that they cultured [38].…”

Section: Discussionmentioning

confidence: 63%