Clinical Significance of Cervical Low-Grade Squamous Intraepithelial Lesions: 8 Years’ Experience

Abstract

Objective:The aim of the present study was to evaluate the follow-up results in patients who initially had cervical smear results showing low-grade squamous intraepithelial lesions (LSIL) in order to determine their histologic outcomes and develop a management guideline. Methods:A total of 240 non-pregnant women with LSIL in their cervical smears were evaluated with colposcopy, and colposcopically directed biopsies and endocervical sampling were done as indicated. Patients had follow-up smears every 3 to 4 months. Results:Of the 240 patients with LSIL, 108 patients (62.8%) were classified as having cervical intraepithelial neoplasia 1 (CIN 1), 28 (16.3%) cases had CIN 2, 12 patients (6.8%) had CIN 3, and 4 patients (2.3%) were diagnosed with invasive cervical carcinoma. At 12-month follow-up, persistence was observed in 38 (22%) cases, and progression to high-grade dysplasia was seen in 16 (9%) cases. Regression to normal smear was observed in 118 cases (68%). Conclusion:Since cervical minor abnormalities can change to low-grade lesions, high-grade lesions, or even cervical carcinoma, colposcopy was found to be an appropriate method for a correct diagnosis. Colposcopy in combination with smear was the ideal approach during follow-up.