Clinical significance of cancer cells in the circulating blood

Roberts, Sophia; Jonasson, Olga; Long, Lina; Mcgrath, Ruth G.; McGrew, Elizabeth A.; Cole, Warren H.

doi:10.1097/00006534-196201000-00035

Cited by 8 publications

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“…22,36 Moreover, among the three patterns of vascular invasion ('filling', 'floating' and 'occlusive'), 21 the latter type with the fibro-inflammatory reaction may even be protective against subsequent recurrent disease, reducing the likelihood of distant metastases 21 and has been shown to be associated with a better OS. 22 As we did not observe any independent relationship between different types of vascular invasion and survival when occurring in association with pericolonic tumor deposits (Table 3), we conclude that pericolonic tumor deposits may actually represent a distinct and more structured type of extravascular vein invasion (much more efficient than the simple tumor cell embolization 37 ), and that their occurrence should be kept separated from other types of vascular invasion in the pathology report. Pericolonic tumor deposits without lymphocytes might represent a form of in transit metastases of colonic carcinomas, worth being classified as pM1 by virtue of their remarkable impact on patients' prognosis, rather than simple vascular (venous) invasion among pT-related 'optional descriptors', 4 as previously suggested by Goldstein.…”

Section: Discussionmentioning

confidence: 58%

Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor staging

et al. 2007

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Section: Discussionmentioning

confidence: 58%

Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor staging

et al. 2007

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“…In the current study, blood was collected immediately after celiotomy and before any mobilization of the tumor‐bearing bowel to exclude the influence of tumor cells shedding into the blood stream during surgical manipulation as demonstrated by experimental and clinical studies 6, 13, 17, 33–36. To discard the first 20 mL of collected blood was another step against eventual contamination with normal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of tumor cells in peripheral blood has been reported to be a factor for poor prognosis 1–4. Detection of tumor cells in bone marrow aspirates and peripheral blood from colorectal carcinoma patients traditionally has been performed by cytology5–8 or immunohistochemistry using anticytokeratin antibodies 9–11. In recent years, these methods have been replaced by reverse transcriptase‐polymerase chain reaction (RT‐PCR) with cytokeratin12, 13 or carcinoembryonic antigen (CEA) mRNA3, 14–17 as a target.…”

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confidence: 99%

Detection of tumor cells in the portal and peripheral blood of patients with colorectal carcinoma using competitive reverse transcriptase-polymerase chain reaction

Sadahiro

Suzuki

Tokunaga

et al. 2001

Cancer

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BACKGROUND In spite of many reports, it remains unclear whether the presence of tumor cells in circulating blood flow predicts a poor prognosis. METHODS Competitive seminested reverse transcriptase‐polymerase chain reaction (RT‐PCR), a technique for the quantitative detection of tumor cells, was applied to detect the presence of tumor cells in portal and peripheral blood samples from 121 patients with colorectal carcinoma and to clarify their clinical significance. This technique can detect one carcinoembryonic antigen (CEA) mRNA‐expressing tumor cell in 1 × 105 normal lymphocytes. RESULTS Six of 33 healthy volunteers (18%) demonstrated a positive reaction to this technique. CEA mRNA expression was detected in the portal blood in 51% of patients and in the peripheral blood in 42% of patients. The results from the two blood samples were consistent in 91% of patients. The positive expression rates for portal blood in patients with T1 tumors and those with TNM Stage I disease were 38% and 45%, respectively. The positive rate was significantly higher in patients with colon carcinoma and those with Stage III or IV disease. CEA mRNA expression, quantitatively measured (× 10−8/β‐actin), was 22.9 ± 35.1 in the portal blood and 19.9 ± 40.0 in the peripheral blood, with no statistically significant difference. A significant positive correlation was noted between portal and peripheral CEA mRNA expression levels according to Speaman correlation analysis (correlation coefficient = 0.78; P < 0.01). Multivariate analysis revealed that the positive rate and level of CEA mRNA expression in the portal and peripheral blood did not appear to be influenced by the established prognostic factors. CONCLUSIONS The presence of circulating tumor cells might be of less value as a prognostic factor because they also can be detected in patients with early‐stage colorectal carcinoma and appeared to be independent of the conventional prognostic factors. Cancer 2001;92:1251–58. © 2001 American Cancer Society.

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“…Nevertheless, in clinical terms, not all circulating cancer cells give rise to metastases. Several reports have shown that patients with malignant cells in the venous blood fare no worse than those without (Engell, 1955;Roberts et al, 1961;Sellwood et al, 1965). Also, there is little evidence that manipulation per se can increase the number of malignant cells discharged into the circulation.…”

Section: Discussionmentioning

confidence: 99%

Adjuvant cytotoxic liver perfusion for colorectal cancer

Taylor

Rowling

West

1979

Journal of British Surgery

103

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Colorectal liver metastases develop by malignant cells entering the portal venous circulation. A randomized prospective clinical trial was commenced in 1975 to assess the value of adjuvant umbilical vein cytotoxic perfusion (with 5-fluorouracil) following colorectal resection. One hundred and fifty-four patients without macroscopic liver secondaries have so far entered the trial. The mean age, sex, site and stage of the disease were similar in the control and perfusion groups and there was no statistically significant difference in postoperative complications or hospital stay (17.1 +/- 7.9 days control, 15.8 +/- 7.4 days perfusion group). So far, 23 deaths have occurred in the control group (20 due to recurrent disease) and 7 in the perfusion group (5 due to recurrent disease). Liver metastases were present in 13 control patients and 2 perfusion patients. These results show an encouraging trend and suggest that adjuvant cytotoxic liver perfusion may reduce the development of colorectal liver metastases and hence improve the subsequent prognosis.

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Clinical significance of cancer cells in the circulating blood

Cited by 8 publications

References 0 publications

Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor staging

Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor staging

Detection of tumor cells in the portal and peripheral blood of patients with colorectal carcinoma using competitive reverse transcriptase-polymerase chain reaction

Adjuvant cytotoxic liver perfusion for colorectal cancer

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