Clinical significance of calcium‐binding protein S100A8 and S100A9 expression in non‐small cell lung cancer

Huang, He; Huang, Qingdong; Tang, Tingyu; Gu, Liang; Du, Jing; Li, Zhijun; Lü, Xiaoling; Zhou, Xiaoxi

doi:10.1111/1759-7714.12649

Cited by 23 publications

(21 citation statements)

References 15 publications

(24 reference statements)

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“…Previous studies reported differential expression of S100A9 in non-small cell lung cancer [11], breast cancer [12,13], gastric cancer [14], and colorectal cancer [15] by immunohistochemistry, consistent with the results of the present immunohistochemistry and microdissection-based mRNA analyses of OS and normal bone tissues. Therefore, differential expression of S100A9 in OS and normal tissues suggests that quantitative analysis of S100A9 mRNA levels in OS may be a promising modality for detecting OS.…”

Section: Discussionsupporting

confidence: 92%

Clinical importance of S100A9 in osteosarcoma development and as a diagnostic marker and therapeutic target

Liu¹,

Luo²,

2019

Bioengineered

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Objective: S100A9 is a calcium-and zinc-binding molecule of S100 family. The aim of the study was to evaluate the role of S100A9 in osteosarcoma (OS) and its value as a diagnostic and therapeutic target in OS. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR), immunohistochemistry and microdissection-based mRNA analysis were used to detect S100A9 mRNA and protein expression in OS and normal bone tissues and its potential as a diagnostic marker in OS. In vitro experiments with RNA interference were performed to evaluate the functional role of S100A9 and its potential as a therapeutic target in OS. Results: S100A9 mRNA levels were significantly higher in OS tissues than that of in normal bone tissues. Receiver operating characteristic curves showed that S100A9 could be a useful diagnostic marker in OS.In vitro data showed that inhibition of S100A9 decreased the proliferation and invasiveness of OS cells, and these findings were supported by microarray data. Conclusions: Assessment of S100A9 mRNA expression is a promising tool for the diagnosis of OS, and S100A9 may be a promising therapeutic target in OS. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 92%

Clinical importance of S100A9 in osteosarcoma development and as a diagnostic marker and therapeutic target

Liu¹,

Luo²,

2019

Bioengineered

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“…20 Proteins in the S100 family are involved in the regulation of a number of cellular processes, such as cell cycle progression and differentiation. 21 Previous studies have revealed that elevated S100A7 is associated with tumor aggressiveness and metastasis. [22][23][24] Hu et al reported that S100A7 expression is significantly increased in lung cancer, and is associated with poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…S100A7 is a calcium‐binding protein that belongs to the S100 family . Proteins in the S100 family are involved in the regulation of a number of cellular processes, such as cell cycle progression and differentiation . Previous studies have revealed that elevated S100A7 is associated with tumor aggressiveness and metastasis .…”

Section: Discussionmentioning

confidence: 99%

Genetic analyses of differences between solid and nonsolid predominant lung adenocarcinomas

Luo

Shi

et al. 2018

Thoracic Cancer

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BackgroundSolid predominant lung adenocarcinomas (LUAD) have distinct histopathological and clinical characteristics compared with nonsolid subtypes. A comprehensive comparison of altered genes found in solid and nonsolid subtypes has not previously been performed. In this study, we analyzed differences in gene expression, genetic mutations, and DNA methylation to better understand the risk factors for these two subtypes of LUAD.MethodsDifferentially expressed genes (DEGs) and differentially mutated genes (DMGs) were analyzed from RNA‐seq data downloaded from The Cancer Genome Atlas (TCGA) and Broad Institute database. To understand the functional significance of molecular changes, we examined the DEGs and DMGs with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis.ResultsA total of 184 patients in the TCGA cohort and 140 patients in the Broad Institute cohort were included in this study. We identified 75 DEGs, of which 15 were upregulated and 56 downregulated in the solid group relative to the nonsolid group. The DEGs were mainly involved in the regulation of water and fluid transport. We discovered 38 significantly differentially expressed genes that overlapped in the two groups. The DMGs were mainly enriched for pathways involved in cell–cell adhesion, cell adhesion, biological adhesion, and hemophilic cell adhesion. We additionally discovered nine significantly methylated genes between solid and nonsolid LUAD.ConclusionsOur study identified distinct DEGs, DMGs, and methylation genes for solid and nonsolid LUAD subtypes. These findings improve our understanding of the different carcinogenesis mechanisms in LUAD and will help to develop new therapeutic strategies.

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“…S100A9 is a posttranslation-modified, calciumbinding protein with multiple ligands that is involved in the pathogenesis of inflammatory events and the initial development of cancer cells [16][17][18][19]. According to the previous reports, S100A9 is associated with poor overall survival of non-small-cell lung cancer (NSCLC) patients [20,21]. TGF-β signaling has been shown to cooperate with S100A9 to influence cancer metastasis [22,23]; NF-κB binds to the S100A9 promoter and activates reactive oxygen species-dependent signaling pathways, protecting hepatocellular carcinoma cells from the apoptotic death [24].…”

Section: Discussionmentioning

confidence: 99%

Saliva proteomic analysis reveals possible biomarkers of renal cell carcinoma

Zhang

et al. 2020

Open Chemistry

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Early diagnosis is a key to improve the prognosis of renal cell carcinoma (RCC); however, reliable RCC biomarkers are lacking in clinical practice. In this study, we used isobaric tags for relative and absolute quantification-based mass spectrometry to identify salivary proteins as biomarkers for the diagnosis of RCC. The objective of this study is to discover biomarkers from saliva by utilizing high-throughput quantitative proteomics approaches. Saliva proteins from 124 RCC patients and healthy individuals were identified and quantified. RCC putative biomarkers were verified by real-time polymerase chain reaction or enzyme-linked immunosorbent assay in a prevalidation sample set. Seventy-one differentially expressed salivary proteins were identified. Serotransferrin, haptoglobin, KRT9, and S100A9, which in previous studies were found to be most closely related to cancers, were selected as putative RCC biomarkers. Haptoglobin and S100A9 were significantly elevated in RCC compared with healthy control samples, although the expression of serotransferrin and KRT9 did not differ between the groups. Furthermore, receiver operating characteristic curves with a cut-off value of 75.49 ng/mL for S100A9 revealed a sensitivity of 87.10% and a specificity of 91.94% for discriminating RCC patients from healthy individuals. Salivary haptoglobin differentiated RCC patients from healthy controls with a sensitivity of 85.48% and specificity of 80.65% (cut-off value 43.02 µg/mL). These results provide experimental evidence to support S100A9 and haptoglobin as potential novel, noninvasive biomarkers for the diagnosis of RCC.

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Clinical significance of calcium‐binding protein S100A8 and S100A9 expression in non‐small cell lung cancer

Cited by 23 publications

References 15 publications

Clinical importance of S100A9 in osteosarcoma development and as a diagnostic marker and therapeutic target

Clinical importance of S100A9 in osteosarcoma development and as a diagnostic marker and therapeutic target

Genetic analyses of differences between solid and nonsolid predominant lung adenocarcinomas

Saliva proteomic analysis reveals possible biomarkers of renal cell carcinoma

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