Clinical significance of C-Reactive Protein to Lymphocyte Count Ratio as a prognostic factor for Survival in Non-small Cell Lung Cancer Patients undergoing Curative Surgical Resection

Hwang, Jae Joon; Hur, Joon Young; Eo, Wankyu; An, Soomin; Kim, Dae Hyun; Lee, Sookyung

doi:10.7150/jca.58094

Cited by 8 publications

(5 citation statements)

References 30 publications

(52 reference statements)

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“…Authors studied pre-operative CLR values of the subjects with oral squamous cell carcinoma and concluded that CLR was associated with better prognostic performance compared to other inflammatory markers and elevated CLR levels indicated poor overall and disease-free survival in this population 16 18 . Moreover, prognostic value of elevated CLR has been also shown in patients with lung cancer 19 , osteosarcoma 20 , and cholangiocarcinoma 21 . It is a fact that malignant conditions are associated with increased inflammatory burden 22 , as seen in patients with COVID-19 infection.…”

Section: Discussionmentioning

confidence: 95%

La proporción de proteína C reactiva a linfocitoE es un marcador confiable en pacientes con infección por COVID-19; el estudio CLEAR COVID

Demirkol¹,

Bilgin²,

Kahveci³

et al. 2022

CIRU

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Objective: COVID-19 infection is characterized with elevation of inflammatory markers in bloodstream. A novel inflammatory marker, C-reactive protein (CRP)-to-lymphocyte ratio (CLR), is suggested to be associated with inflammation. We aimed to compare the CLR values of the deceased COVID-19 patients to the CLR of survived subjects. Materials and Methods: The patients with COVID-19 whom presented to outpatient or inpatient clinics of AbantIzzet Baysal University Hospital were enrolled to the present retrospective study. Subjects were grouped as either deceased or survived. CLR values of the groups were compared. Results: Study cohort was consisted of 568 subjects in deceased and 4753 patients in survived group. Median CLR of the deceased and survived groups were 90 (0.2-1679)% and 11 (0.2-1062)%, respectively (p < 0.001). The sensitivity (75%) and specificity (70%) of CLR (> 23.4% level) in detecting mortality were higher than those of CRP and ferritin (AUC: 0.80, p < 0.001, 95% CI: 0.78-0.82). Conclusion: We suggest that elevated CLR levels in COVID-19 patients on admission should alert physicians for poor outcome.

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Section: Discussionmentioning

confidence: 95%

La proporción de proteína C reactiva a linfocitoE es un marcador confiable en pacientes con infección por COVID-19; el estudio CLEAR COVID

Demirkol¹,

Bilgin²,

Kahveci³

et al. 2022

CIRU

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“…Subsequently, Mungan et al 13 confirmed the results of Meng et al 12 . In addition, prognostic value of elevated CLR has also been shown in patients with osteosarcoma 14 , cholangiocarcinoma 15 , and lung cancer 16 . It is a fact that malignant conditions are associated with increased inflammatory burden 17 , as seen in patients with CHC.…”

Section: Discussionmentioning

confidence: 98%

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

Demirkol

Aktas

Bilgin

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Chronic hepatitis C (CHC) is one of the most important health problems affecting the significant rate of world population and it may lead to cirrhosis and hepatocellular carcinoma. C-reactive protein to lymphocyte count ratio (CLR) is used in estimating inflammatory burden. Therefore, this study aimed to compare CLR values between CHC patients and healthy controls and between CHC patients with and without fibrosis. METHODS: Patients with CHC infection who visited outpatient and inpatient internal medicine clinics of our institution between January 2021 and December 2021 were enrolled to this retrospective study. CLR of the patients with CHC and healthy controls were compared. We further compared CLR of CHC patients with and without fibrosis. RESULTS: Median CLR of CHC and control subjects was 2.61 (5.13%) and 0.31 (0.37%), respectively. CLR of the CHC group was significantly increased compared to the CLR of the controls (p<0.001). There was a significant positive correlation between CLR and APRI score (r=0.15, p=0.04). The sensitivity and specificity of CLR in determining CHC above 0.58% level were 84% and 82%, respectively (AUC: 0.884, p<0.001, 95%CI 0.84-0.93). In subgroup analysis, CLR was 3.97 (6.6%) for CHC patients with fibrosis and 1.7 (4.4%) for CHC subjects without fibrosis (p=0.001). CONCLUSIONS: Increased CLR in patients with CHC may be an alarming finding of liver fibrosis, as CLR is associated with both CHC and hepatic fibrosis.

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“…Hwang et al recently demonstrated that the CLR was a determinant biomarker in overall survival and disease-specific survival in gastric carcinoma patients. 45 The higher CLR maybe represent a poor long-term outcome in colorectal liver metastases patients after hepatic resection. 33 Interestingly, there is no report to research the relationship between CLR and diabetes at present; the present study is the first report.…”

Section: Discussionmentioning

confidence: 99%

The Novel Predictive Biomarkers for Type 2 Diabetes Mellitus in Active Pulmonary Tuberculosis Patients

Yu¹,

Weng²,

Luo³

et al. 2022

IDR

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Purpose This study was to explore the predictive value of monocyte to high-density lipoprotein cholesterol ratio (MHR), neutrophils to high-density lipoprotein cholesterol ratio (NHR), C-reactive protein-to-lymphocyte ratio (CLR), and C-reactive protein-to-albumin ratio (CAR) for type 2 diabetes mellitus (T2DM) in patients with active pulmonary tuberculosis (APTB). Patients and Methods A total of 991 active pulmonary tuberculosis (APTB) patients (201 with T2DM) were hospitalized in the Department of Tuberculosis, Wuhan Jinyintan Hospital, Tongji Medical College, Huazhong University of Science and Technology were included. The routine blood examination indicators and biochemical parameters were collected to calculate MHR, NHR, CLR, and CAR. The Pearson correlation analysis, Univariate Logistic regression analysis, and receiver operating characteristic (ROC) curve analysis were performed to assess the predictive value of MHR, NHR, CLR, and CAR for APTB-T2DM patients. Results The levels of MHR, NHR, CLR, and CAR in the APTB-T2DM patients were significantly higher than in the APTB-no T2DM patients (P < 0.05). Additionally, the MHR, NHR, CLR, and CAR have a positive correlation with fasting blood glucose in the whole study population. However, in the APTB-T2DM patients, MHR, NHR, and CAR were not correlated with fasting blood glucose, and only CLR was positively correlated with fasting blood glucose. The area under curve (AUC) predicting APTB-T2DM patients of the MHR, NHR, CLR, and CAR was 0.632, 0.72, 0.715, and 0.713, respectively. Further, univariate logistic regression analyses showed that the higher MHR, NHR, CLR, and CAR were independent risk factors for APTB-T2DM (P < 0.01). The MHR, NHR, CLR, and CAR quartiles were used to divide the APTB patients into four groups for further analysis. The prevalence of T2DM was significantly higher in APTB individuals as MHR, NHR, CLR, and CAR values increased (P < 0.05). Conclusion MHR, NHR, CLR, and CAR are simple and practicable inflammatory parameters that could be used for assessing T2DM in APTB. APTB patients have a greater possibility to be diagnosed with T2DM with the higher MHR, NHR CLR, and CAR values. Therefore, more attention should be given to the indicator in the examination of APTB.

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Clinical significance of C-Reactive Protein to Lymphocyte Count Ratio as a prognostic factor for Survival in Non-small Cell Lung Cancer Patients undergoing Curative Surgical Resection

Cited by 8 publications

References 30 publications

La proporción de proteína C reactiva a linfocitoE es un marcador confiable en pacientes con infección por COVID-19; el estudio CLEAR COVID

La proporción de proteína C reactiva a linfocitoE es un marcador confiable en pacientes con infección por COVID-19; el estudio CLEAR COVID

C-reactive protein to lymphocyte count ratio is a promising novel marker in hepatitis C infection: the clear hep-c study

The Novel Predictive Biomarkers for Type 2 Diabetes Mellitus in Active Pulmonary Tuberculosis Patients

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