Clinical significance of brain natriuretic peptide in primary pulmonary hypertension

Leuchte, Hanno; Holzapfel, Michael; Baumgärtner, R; Ding, Isabelle; Neurohr, Claus; Vogeser, Michael; Kolbe, Tilman; Schwaiblmair, Martin; Behr, Jürgen

doi:10.1016/j.jacc.2003.09.051

Cited by 256 publications

(150 citation statements)

References 36 publications

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“…It has been observed in the previous studies that excessive increases occur in the plasma levels in the presence of especially left ventricular dysfunction [7,8]. In subsequent studies, it has been found that plasma BNP level elevates in proportion to the extent of the right ventricular dysfunction in diseases, like primary pulmonary hypertension, cor pulmonale and pulmonary emboli that affect the pulmonary bed and the right heart [9][10][11]. Since MS is a disease affecting the right heart, it is expected to raise BNP.…”

Section: Introductionmentioning

confidence: 95%

The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis

Eryol

Doğan

Özdoğru

et al. 2006

Int J Cardiovasc Imaging

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B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are both secreted primarily from the ventricle myocardium in response to the increase in volume and pressure. We aimed to investigate the relationship between the severity of mitral stenosis (MS) and the level of plasma BNP. A total of 56 patients (50 female, 6 male) were included in the study. Mitral stenosis and its related parameters were evaluated by echocardiographic methods. Patients were divided into three groups as with mild, moderate and severe MS according to their planimetric valvular area. Plasma BNP levels were measured using "Triage-B-type natriuretic peptide test" method (Biosite Diagnostics, San Diego). The relationship of BNP with mitral stenosis and other echocardiographic parameters were studied. The comparison of the 3 groups with one another revealed that the BNP level in the group with moderate MS was higher than that in the group with mild MS, however it was statistically insignificant (74.9 +/- 49.7 versus 49.9 +/- 40.5 pg/ml, p > 0.05). BNP level in the group with severe MS was significantly higher than that in the mild MS (144.3 +/- 83.9 versus 49.9 +/- 40.5 pg/ml, p < 0.001) and that in the moderate MS group (144.3 +/- 83.9 versus. 74.9 +/- 49.7 pg/ml, p < 0.05). When patients were taken together, as the area of the mitral valve decreased, the level of BNP underwent a corresponding increase (r:-0.48, p < 0.001). We have ascertained that the level of plasma BNP and the degree of MS are significantly correlated, and as MS becomes more serious, the plasma BNP level rises.

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Section: Introductionmentioning

confidence: 95%

The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis

Eryol

Doğan

Özdoğru

et al. 2006

Int J Cardiovasc Imaging

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“…62,66,[90][91][92][93] For example, as discussed above, studies have demonstrated neurohormonal changes in adults and children with CHD similar to those in acquired HF. 62,66,90,91 Therapies that reverse remodeling or slow the remodeling process were shown to improve survival in patients with LV systolic dysfunction caused by acquired heart disease.…”

Section: Hf Pharmacotherapy Applied In Chdmentioning

confidence: 93%

Chronic Heart Failure in Congenital Heart Disease

Stout¹,

Broberg²,

Book³

et al. 2016

Circulation

287

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“…6 The proteins BNP/N-terminal pro b-type natriuretic peptide are associated with pulmonary hemodynamics and right ventricular dysfunction in PH, and BNP levels within World Health Organization functional class II do not increase. [22][23][24] We previously reported that sLR11 is produced by immature, but not by mature, SMC, in atherosclerotic arteries and that LR11 mRNA expression is high in human CD34 + and …”

Section: Soluble Lr11 As a Biomarker Of Proliferative Smc In Patientsmentioning

confidence: 99%

Deletion of LR11 Attenuates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation With Medial Thickening in Mice

Jiang

Konishi

Nurwidya

et al. 2016

ATVB

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Objective-We aimed to determine whether LR11 (low-density lipoprotein receptor with 11 binding repeats) is a potential key regulator of smooth muscle cell (SMC) proliferation during the progression of hypoxia-induced medial thickening in mice and whether sLR11 (soluble LR11) can serve as a biomarker in patients with pulmonary arterial hypertension. Approach and Results-The role of LR11 in pulmonary arterial hypertension was investigated using mouse and cell models of induced hypoxia. The expression of LR11 and of hypoxia-inducible factor-1α was significantly increased in lung tissues from C57Bl/6 mice after 3 weeks of exposure to hypoxia compared with normoxia. Serum sLR11 levels were also increased. Physiological and histochemical analyses showed that increased right ventricular systolic pressure, right ventricular hypertrophy, and medial thickening induced under hypoxia in wild-type mice were attenuated in LR11−/− mice. The proliferation rates stimulated by hypoxia or platelet-derived growth factor-BB were attenuated in SMC derived from LR11 −/− mice, compared with those from wild-type mice. Exogenous sLR11 protein increased the proliferation rates of SMC from wild-type mice. The expression of LR11 and hypoxia-inducible factor-1α was increased in cultured SMC under hypoxic conditions, and hypoxia-inducible factor-1α knockdown almost abolished the induction of LR11. Serum sLR11 levels were significantly higher in patients with, rather than without, pulmonary arterial hypertension. sLR11 levels positively correlated with pulmonary vascular resistance and mean pulmonary arterial pressure. Conclusions-LR11 regulated SMC proliferation during the progression of hypoxia-induced medial thickening in mice.The findings obtained from mice, together with those in humans, indicate that sLR11 could serve as a novel biomarker that reflects the pathophysiology of proliferating medial SMC in pulmonary arterial hypertension. (Arterioscler Thromb

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Clinical significance of brain natriuretic peptide in primary pulmonary hypertension

Abstract: Our data suggest that plasma BNP levels are closely related to the functional impairment of PPH patients and parallel the extent of pulmonary hemodynamic changes and right heart failure. Serial measurements of plasma BNP concentrations may help improve the management of PPH patients.

Cited by 256 publications

References 36 publications

The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis

The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis

Chronic Heart Failure in Congenital Heart Disease

Deletion of LR11 Attenuates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation With Medial Thickening in Mice

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