Clinical significance of bendopnea in heart failure—Systematic review and meta-analysis

Pranata, Raymond; Yonas, Emir; Chintya, Veresa; Alkatiri, Amir Aziz; Siswanto, Bambang Budi

doi:10.1016/j.ihj.2019.05.001

Cited by 12 publications

(9 citation statements)

References 9 publications

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“…[16][17][18] Conversely, there are conflicting results regarding the prognostic role of bendopnea in different HF scenarios. 3,5,19 Similar to previous reports, 1,3,5,20 the prevalence of bendopnea in our population was 21%. When we evaluated the agreement between the patient-reported shortness of breath during the bending manoeuvre and the observed SpO 2 changes, we observed a moderate agreement between BOSI and bendopnea when BOSI was ≥−3%.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, orthopnoea and increased JVP are both associated with an increased risk for HF hospitalization 16–18 . Conversely, there are conflicting results regarding the prognostic role of bendopnea in different HF scenarios 3,5,19 …”

Section: Discussionmentioning

confidence: 99%

“…in both groups (35 [29-41] vs. 22[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] mmHg, p = 0.01).…”

mentioning

confidence: 99%

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Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure

Espriella

Amiguet

Miñana

et al. 2022

European J of Heart Fail

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Aims Bendopnea is a clinical symptom of advanced heart failure with uncertain prognostic value. We aimed to evaluate whether bendopnea and the change in oxygen saturation when bending forward (bending oxygen saturation index [BOSI]) are associated with adverse outcomes in ambulatory chronic heart failure (CHF) patients. Methods and results We prospectively evaluated 440 subjects with symptomatic CHF. BOSI was defined as the difference between sitting and bending oxygen saturation (SpO2). The endpoint was the total number of worsening heart failure (WHF) events (heart failure hospitalization or urgent heart failure visit requiring parenteral diuretic therapy). The mean age was 74 ± 10 years, 257 (58.6%) were male, and 226 (51.4%) had a left ventricular ejection fraction <50%. Bendopnea was present in 94 (21.4%) patients, and 120 (27.3%) patients had a BOSI ≥−3%. The agreement between BOSI ≥−3% and bendopnea was moderate (Gwet's AC 0.482, p < 0.001). At a median (p25%–p75%) follow‐up of 2.17 years (0.88–3.16), we registered 441 WHF events in 148 patients. After multivariable adjustment, BOSI was independently associated with the risk for total WHF episodes (overall, p < 0.001). Compared to improvement/no change in SpO2 when bending (BOSI 0%), those with BOSI ≥−3% showed an increased risk of WHF events (incidence rate ratio [IRR] 2.16, 95% confidence interval [CI] 1.67–2.79; p < 0.001). In contrast, bendopnea was not associated with the risk of total WHF episodes (IRR 1.04, 95% CI 0.83–1.31; p = 0.705). Conclusions In ambulatory and stable CHF patients, BOSI ≥−3% and not bendopnea was independently associated with an increased risk of total (first and recurrent) WHF episodes. Awareness of SpO2 while assessing bendopnea may be a useful tool for predicting heart failure decompensations.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure

Espriella

Amiguet

Miñana

et al. 2022

European J of Heart Fail

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“…Considering their dependence on these medications, any terminations can lead to acute and chronic complications. Often, poor drug compliance results in acute crises; for example: forgetting to take insulin, antihypertensive medications, and heart failure medications are among the most common causes of hyperglycaemic crises, hypertensive emergencies, and acutely decompensated heart failure [10,11], respectively. Thrombosis of coronary stents, mechanical valves, or other endovascular devices has a high mortality rate; therefore, discontinuation of certain drugs in such cases can lead to catastrophic events.…”

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confidence: 99%

A wave of non-communicable diseases following the COVID-19 pandemic

Lim

Huang

Yonas

et al. 2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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“…Согласно данным мета-анализа [4], распространенность бендопноэ среди пациентов с систолической ХСН колеблется от 18 до 31,6 % вне зависимости от возраста и пола. Кроме того, в указанном мета-анализе установлено, что по результатам проведенных исследований нет достоверной связи между наличием симптома бендопноэ и такими сопутствующими заболеваниями, как хроническая обструктивная болезнь легких, сахарный диабет, гипертоническая болезнь и фибрилляция предсердий [3,[5][6][7].…”

Section: Discussionunclassified

Risk Assessment of Development of the Major Adverse Cardiac Events in Patients with Chronic Heart Failure with a Preserved and Intermediate Ejection Fraction in the Presence of a Bendopnea Symptom

et al. 2020

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Aim To evaluate the risk of major cardiovascular complications (CVC) in patients with chronic heart failure (CHF) with intermediate and preserved ejection fraction (EF) depending on the presence of bendopnea symptom.Material and methods The study included 104 patients with stage II CHF and left ventricular EF ≥40 %. Mean age of the patients was 72.8±10.6 years. A test for detection of bendopnea symptom was performed for all patients. Two groups were formed: group 1, 69 patients with the bendopnea symptom and group 2, 35 patients with a negative test. Follow-up duration was 24 months. The composite endpoint (CEP) was death and hospitalization for any CVC.Results Mean time to the bendopnea symptom was 17.3±6.61 s. At two years of follow-up, the CEP was observed in 36 (34.6 %) patients, including 30 (43.5 %) patients in group 1 and 6 (17.1 %) patients in group 2. 12 patients died, and 9 of them had the bendopnea symptom. 21 patients of group 1 were hospitalized for CVC. Risk of CEP was significantly 1.7 times higher for men (relative risk, RR 1.7 [1.1; 2.6]) than for women. The presence of bendopnea symptom increased the risk of CEP 1.4 times (ОР 1.4 [1.1;1.9]) for women and 2.3 times (RR 2.3 [1.4; 3.6]) for men.Conclusion Results of the study demonstrated an unfavorable effect of bendopnea symptom on risk of CEP during the two-year follow-up of CHF patients with preserved and intermediate EF.

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Clinical significance of bendopnea in heart failure—Systematic review and meta-analysis

Cited by 12 publications

References 9 publications

Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure

Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure

A wave of non-communicable diseases following the COVID-19 pandemic

Risk Assessment of Development of the Major Adverse Cardiac Events in Patients with Chronic Heart Failure with a Preserved and Intermediate Ejection Fraction in the Presence of a Bendopnea Symptom

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