Clinical significance of aromatase protein expression in axillary node negative breast cancer

Lu, Jingsong; Li, Hecheng; Cao, Daocheng; Di, Gen-Hong; Wu, Jiong; Sheng, Kunwei; Han, Qixia; Shen, Zhenzhou; Shao, Zhi‐Ming

doi:10.1007/s00432-006-0186-5

Cited by 6 publications

(10 citation statements)

References 34 publications

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“…Di et al When we evaluated only IDC we found a statistically significant positive correlation between aromatase and MMP-2 (p=0.001) and between aromatase and MMP-9 (p=0.034). Similar results were obtained by Di et al (2005) and Lu et al (2007) with p<0.001 21,22 . These results and others that show positive correlation between aromatase and MMP-2 and aromatase and MMP-9 increase the possibility that aromatase can elevate the invasion capacity of tumor cells by increasing the activity of MMP-2 and MMP-9.…”

Section: Discussionsupporting

confidence: 90%

“…Eppenberger et al (2001) 39 found that women with high aromatase expression in breast cancer have increased 22 in the univariate survival analysis showed that aromatase is significantly and positively associated with decreased overall survival (OS) (p= 0.04) in the estrogen receptor (ER) and/or progesterone receptor (PR), positive patients (10 year OS 100% for the aromatasenegative group compared with 85.1% for the aromatase-positive group). However, in the multivariate survival analysis, we did not find this association to be significant (p> 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Di et al (2005) 21 , through PCR analysis of breast cancer tissues, found a positive correlation between aromatase, MMP-2, and MMP-9 (p<0.01). Lu et al (2007) 22 demonstrated a positive correlation between aromatase, MMP-2, and MMP-9 in breast cancer tissues positive for hormonal receptors (p<0.05).…”

Section: Introductionmentioning

confidence: 96%

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The interaction between aromatase, metalloproteinase 2,9 and cd44 in breast cancer

Bagnoli

Oliveira²,

Silva

et al. 2010

Rev. Assoc. Med. Bras.

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SummaryobjectIve. This study intends to verify the expression levels and correlation of aromatase, matrix metalloproteinase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9) and CD44 in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC) when both are found in the same breast. Methods. One hundred and ten cases were evaluated by tissue microarray (TMA) and immunohistochemically screened with anti-aromatase polyclonal antibodies, anti-MMP-2 monoclonal antibodies, anti-MMP-9 policlonal antibodies and anti-CD44 monoclonal antibodies. results. Aromatase was expressed in IDC and DCIS in 63 (57.3%) and 60 (67%) of the cases respectively; MMP-2 was similarly expressed in IDC and DCIS in 15 (13.60%) cases; MMP-9 was positively expressed in IDC and DCIS in 83 (75.50%) and 82 (74.50%) cases, respectively; CD44 was positively expressed in IDC and DCIS in 49 (44.50%) and 48 (42.60%) of the cases, respectively; all of them were highly correlated (p<0,001). The correlation analysis found positive, statistically significant correlation, in IDC between aromatase and MMP-2 (p<0.001) and between aromatase and MMP-9 (p=0.034). Positive correlation between aromatase and MMP-2 (p<0.001) and between MMP-9 and CD44 (p=0.030) were found in DCIS. conclusIon. These results allow us to conclude that aromatase through local estrogen synthesis in breast tissue plays an important role in breast carcinogenesis, mainly influencing MMP-2 and MMP-9 which are important participants in tumor cell invasion and dependence of their connection to CD44 for action.Key words: Aromatase. Matrix metalloproteinase 2. Matrix metalloproteinase 9. Antigens CD44. Carcinoma ductal breast.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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The interaction between aromatase, metalloproteinase 2,9 and cd44 in breast cancer

Bagnoli

Oliveira²,

Silva

et al. 2010

Rev. Assoc. Med. Bras.

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“…This observation is supported by activity studies showing a higher enzyme activity of aromatase in the stroma [23,43]. Several investigations of aromatase protein expression and its correlation to patient outcome have been carried out without discriminating between stromal and epithelial localisation [32,33,44], which generate difficulties in comparing results between studies. We also measured the mRNA levels of sulfatase and aromatase and did not find any significant correlation between mRNA and protein levels.…”

Section: Discussionmentioning

confidence: 87%

In situ levels of oestrogen producing enzymes and its prognostic significance in postmenopausal breast cancer patients

Licznerska

Wegman

Nordenskjöld

et al. 2007

Breast Cancer Res Treat

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“…The majority of ER α -positive cells retain their ER α and respond positively to initial endocrine therapy for the treatment of advanced metastatic disease. Several recent studies have detected the presence of ER α expression in metastatic tumors [46–48]. A correlation between ER α -positive tumors and the development of bone metastasis has been observed clinically [49, 50].…”

Section: Erα Regulation Of Metastasismentioning

confidence: 99%

Role of Estrogen Receptor Signaling in Breast Cancer Metastasis

Roy

Vadlamudi

2012

International Journal of Breast Cancer

171

116

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Metastatic breast cancer is a life-threatening stage of cancer and is the leading cause of death in advanced breast cancer patients. Estrogen signaling and the estrogen receptor (ER) are implicated in breast cancer progression, and the majority of the human breast cancers start out as estrogen dependent. Accumulating evidence suggests that ER signaling is complex, involving coregulatory proteins and extranuclear actions. ER-coregualtory proteins are tightly regulated under normal conditions with miss expression primarily reported in cancer. Deregulation of ER coregualtors or ER extranuclear signaling has potential to promote metastasis in ER-positive breast cancer cells. This review summarizes the emerging role of ER signaling in promoting metastasis of breast cancer cells, discusses the molecular mechanisms by which ER signaling contributes to metastasis, and explores possible therapeutic targets to block ER-driven metastasis.

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Clinical significance of aromatase protein expression in axillary node negative breast cancer

Abstract: Our study suggested that local estrogen production by aromatase plays important roles in the growth and invasiveness of breast cancer; tumor aromatase status may be indicative of breast cancer prognosis in some patients.

Cited by 6 publications

References 34 publications

The interaction between aromatase, metalloproteinase 2,9 and cd44 in breast cancer

The interaction between aromatase, metalloproteinase 2,9 and cd44 in breast cancer

In situ levels of oestrogen producing enzymes and its prognostic significance in postmenopausal breast cancer patients

Role of Estrogen Receptor Signaling in Breast Cancer Metastasis

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