Clinical significance of appendiceal diverticulum: a significant marker for appendiceal neoplasia in Australian patients

Abstract

This is the first Australian study demonstrating DAs are a significant marker of appendiceal neoplasm. Appendicectomy in all incidentally discovered diverticulum should be considered. Due to a paucity of data, research is required into this area to assess for the need for endoscopy following diagnosis.

Systematic review and meta‐analysis of the association between diverticulosis of the appendix and neoplasia

“…4,17 The ratio of male to female was 1.8:1 (Table 3). 4,[10][11][12]14,[16][17][18] The pooled prevalence of neoplasia in specimens without DA was 1.28% (130/10 169). 4,5,13,18 The pooled prevalence of neoplasia within specimens with DA was 26.94% (80/297) 4,5,[11][12][13]15,17,18 ( Table 2).…”

“…Collectively from the 11 studies, 17 147 patients underwent appendicectomy, 4,5,[10][11][12][13][14][15][16][17][18] of which 341 patients had DA. The characteristics of the included studies are summarized in Table 1.…”

“…The prevalence rate of DA was 1.74% (297 DA in 17 046 patients) based on the inclusion of eight studies (Table 2). 4,5,[11][12][13]15,17,18 Three studies were case-matched or without a control group and were not appropriate to be included in the calculation of prevalence rate. 10,14,16 The composite mean age of all patients was 41.2 years.…”

“…10,14,16 The composite mean age of all patients was 41.2 years. 4,[10][11][12][14][15][16][17][18] The mean age of patients without DA was 33.9 years. 4,17 The ratio of male to female was 1.8:1 (Table 3).…”

“…4,[10][11][12][14][15][16][17][18] The mean age of patients without DA was 33.9 years. 4,17 The ratio of male to female was 1.8:1 (Table 3). 4,[10][11][12]14,[16][17][18] The pooled prevalence of neoplasia in specimens without DA was 1.28% (130/10 169).…”