Clinical significance of anaemia associated with prolactin-secreting pituitary tumours in men

Iglesias, Pedro; Castro, José Carlos Monteiro de; Díez, Juan J.

doi:10.1111/j.1742-1241.2011.02662.x

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…In men who presented with testosterone below 1 ng/mL, baseline HB levels were significantly lower compared to men with higher testosterone levels (12.6 vs. 13.5 g/dL). Iglesias et al 20 investigated the clinical significance of anemia in 26 men with prolactinoma (four patients with microprolactinoma, and 22 with macroprolactinoma). Nine men (35%) presented with HB below 13.0 g/dL.…”

Section: Discussionmentioning

confidence: 99%

“…18 It was discovered that anemia is a common finding in men with macroprolactinoma, associated with hypogonadism and large tumor size. 19,20 Following treatment with dopamine agonists, achievement of prolactin normalization and an increase in testosterone levels, rising HB levels were observed. 19 As estimation of disease duration based on symptom onset does not work as well in men as it does in women, we searched for a more accurate estimation method in male prolactinoma.…”

Section: Introductionmentioning

confidence: 99%

“…showed that hematopoiesis is impaired in men with low testosterone levels in cases of hypogonadism secondary to pituitary adenoma 18 . It was discovered that anemia is a common finding in men with macroprolactinoma, associated with hypogonadism and large tumor size 19,20 . Following treatment with dopamine agonists, achievement of prolactin normalization and an increase in testosterone levels, rising HB levels were observed 19 …”

Section: Introductionmentioning

confidence: 99%

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Hemoglobin decline as a signal for hyperprolactinemia onset prior to prolactinoma diagnosis in hypogonadal men

et al. 2023

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BackgroundMen harboring prolactinomas frequently suffer from central hypogonadism with secondary anemia. They present insidious and nonspecific symptoms of hypogonadism, making it difficult to diagnose the disease and determine its duration. The result is a delay in diagnosis, which may have harmful hormonal and metabolic consequences. We hypothesized that a decrease in hemoglobin (HB) levels prior to prolactinoma diagnosis, may signal hyperprolactinemia onset and estimate disease duration.MethodsWe retrospectively evaluated the prediagnosis temporal trends in HB levels of 70 males with prolactinoma, diagnosed from January 2010 to July 2022. Men without hypogonadism, patients that received testosterone, and those with unrelated anemia were excluded.ResultsSixty‐one of seventy men (87%) with prolactinoma presented with hypogonadism, and forty men (57%) had HB levels ≤13.5 g/dL at diagnosis. We identified 25 patients with “informative” HB curves (mean age, 46.1±14.9 years; median prolactin, 952 ng/mL; median follow‐up, 14.0 years), demonstrating an obvious prediagnosis HB decrease (greater than 1.0 g/dL), from a prediagnosis baseline HB of 14.4 ± 0.3 to 12.9 ± 0.5 g/dL at diagnosis. The median “low‐HB duration” (from the first low HB measurement to hyperprolactinemia diagnosis) was 6.1 years (IQR, 3.3–8.8 years). In symptomatic patients, we identified a correlation between “low‐HB duration” and patient‐reported sexual dysfunction duration (n = 17, R = 0.502, p = 0.04). The “low‐HB duration” was significantly longer than the reported sexual dysfunction duration (7.0 ± 4.5 vs. 2.9 ± 2.5 years, p = 0.01).ConclusionsIn our cohort of men with prolactinomas and hypogonadism, we found a marked decrease in HB levels that preceded prolactinoma diagnosis by a median of 6.1 years, with a mean delay of 4.1 years between HB decrease and hypogonadal symptoms appearance. These results suggest that HB decline prior to prolactinoma diagnosis may serve as a marker for hyperprolactinemia onset in a subset of hypogonadal men and allow a more accurate assessment of disease duration.

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Section: Discussionmentioning

confidence: 99%