Clinical significance of advanced lung cancer inflammation index, a nutritional and inflammation index, in gastric cancer patients after surgical resection: A propensity score matching analysis

Yin, Chengzeng; Toiyama, Yuji; Okugawa, Yoshinaga; Omura, Yusuke; Kusunoki, Yukina; Kusunoki, Kurando; Imaoka, Yuki; Yasuda, Hiromi; Ohi, Masaki; Kusunoki, Masato

doi:10.1016/j.clnu.2020.07.018

Cited by 27 publications

(44 citation statements)

References 37 publications

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“…37 ALI is an index related to inflammation and nutritional status. 21 The difference between ALI and other previously reported indicators is that ALI not only includes inflammation related NLR and albumin, but also includes BMI, which is used to assess nutritional status. 21 BMI has always been considered a diagnostic criterion for nutrition.…”

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confidence: 96%

“…21 The difference between ALI and other previously reported indicators is that ALI not only includes inflammation related NLR and albumin, but also includes BMI, which is used to assess nutritional status. 21 BMI has always been considered a diagnostic criterion for nutrition. 38 Among elderly community residents, a BMI of less than 22 was associated with a high 1-year mortality rate and poor functional status.…”

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confidence: 96%

“…ALI was originally used to assess the prognosis of lung cancer patients, such as non-small cell lung cancer 28 and small cell lung cancer. 29 Soon after, researchers found that ALI is also a good independent prognostic indicator in nasopharyngeal carcinoma, 30 head and neck squamous cell carcinoma, 31 32 esophageal cancer, 32 gastric cancer, 21,33 colorectal cancer, 34,35 melanoma, 36 and diffuse large B-cell lymphoma. 37 ALI is an index related to inflammation and nutritional status.…”

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confidence: 99%

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Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study

Ruan¹,

Yang²,

Zhang³

et al. 2021

JIR

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Background: Systemic inflammation and cachexia are associated with adverse clinical outcomes in elderly patients with cancer. The survival outcomes of elderly patients with cancer cachexia (EPCC) with high inflammation and a high risk of mortality are unknown. This study aimed to investigate the impact of high inflammation on the prognosis of EPCC patients with high mortality. Patients and Methods: This multicenter cohort study included 746 EPCC (age >65 years) with a mean age of 72.00 ± 5.24 years, of whom 489 (65.5%) were male. The cut-off value for the inflammation index was obtained using the optimal survival curve. The different inflammatory indicators were assessed using the concordance index (C-index), decision curve analysis (DCA), and prognostic receiver operating characteristic (ROC). The high mortality risk group of EPCC was defined by the 2011 Fearon Cancer Diagnostic Consensus. EPCC were divided into the high-risk group, which satisfies three diagnostic criteria, and a low-risk group, which satisfies only one or two diagnostic criteria. Results: The C-index, DCA, and prognostic ROC indicated the superiority of advanced lung cancer inflammation index (ALI) compared with other indicators, including neutrophillymphocyte ratio (NLR), prognostic nutritional index (PNI), systemic immuneinflammation index (SII), and platelet-lymphocyte ratio (PLR). Whether ALI was used as a continuous or a categorical variable, ALI had a better prognostic value in EPCC compared with other inflammatory indicators. In particular, patients with low ALI (<25.03) had a worse overall survival (OS) than patients with high ALI (≥25.03) (P < 0.001, HR [95% CI] = 2. 092 [1.590-2.751]). The combination effect analysis showed that the risk of mortality of the patients in the low-ALI and high-risk groups was 3.095-fold higher than that of patients in the high-ALI and low-risk groups. Conclusion:The prognostic and discriminative value of the inflammatory indicator ALI was better than that of NLR, PNI, SII, and PLR in EPCC. The high-risk group of EPCC with a low ALI would increase the death risk of OS.

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Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study

Ruan¹,

Yang²,

Zhang³

et al. 2021

JIR

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“…A low ALI score, based on a lower BMI or ALR, or a higher NLR, indicates poor nutritional and high inflammatory status. The clinical utility of ALI as a prognostic indicator has been confirmed in several cancers (13)(14)(15)(16). Mandaliya et al (13) demonstrated that ALI could be used to prognosticate patients with non-small cell lung cancer.…”

Section: Discussionmentioning

confidence: 98%

“…Advanced lung cancer inflammation index (ALI) is a novel inflammation and nutritional index by combining body mass index (BMI), preoperative serum albumin, and NLR (12). In recent years, ALI has been proposed as a prognostic biomarker of several cancers, such as lung (13), colorectal (14), esophageal (15), and gastric (16) cancers. To our knowledge, the clinical value of ALI in patients with CCA has not yet been studied.…”

Section: Introductionmentioning

confidence: 99%

Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma

Ding

Lin

et al. 2022

Front. Surg.

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BackgroundThis study aimed to assess the clinical utility of the advanced lung cancer inflammation index (ALI) as a prognostic indicator for patients with cholangiocarcinoma (CCA) and construct a prognostic nomogram based on ALI.MethodsA total of 97 CCA patients who received radical resection were included. The optimal cut-off point for ALI was identified by X-tile analysis. COX regression analysis were used to identify risk factors of overall survival (OS) and disease-free survival (DFS). A predictive nomogram for DFS was constructed.ResultsThe optimal cut-off value for preoperative ALI was 31.8. 35 (36.1%) patients were categorized into the low-ALI group and 62 (63.9%) patients into the high-ALI group. Low ALI was independently associated with hypoproteinemia and lower body mass index (BMI) (all P < 0.05). COX regression analysis revealed that preoperative ALI level (HR = 0.974, P = 0.037) and pathological TNM stage (HR = 7.331, P < 0.001) were independently correlated with OS for patients with CCA, and preoperative ALI level (HR = 0.978, P = 0.042) and pathological T stage (HR = 1.473, P = 0.035) remained to be independent prognostic factors for DFS in CCA patients. Using time-dependent ROC analysis, we found that ALI was better at predicting prognosis than other parameters, such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and prognostic nutritional index (PNI) in terms of OS and DFS. A nomogram predicting DFS was built (C-index: 0.73 95%CI: 0.67–0.79).ConclusionsALI may be useful for prognosis assessment for patients with CCA.

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The advanced lung cancer inflammation index is a novel independent prognosticator in colorectal cancer patients after curative resection

Horino

Tokunaga

Miyamoto

et al. 2021

Annals of Gastroent Surgery

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Background:The advanced lung cancer inflammation index (ALI), which comprehensively evaluates the patient body composition and inflammation/nutritional status, is reportedly associated with the patient outcome in lung cancer. However, the clinical significance in colorectal cancer (CRC) patients after curative resection remains unclear. Methods: A total of 813 CRC patients after curative resection between April 2005 and June 2019 in a single institution were retrospectively enrolled. The association of the preoperative ALI (calculated as follows: body mass index × albumin value/ neutrophil-to-lymphocyte ratio) with clinicopathological factors, postoperative complications, and survival was analyzed.Results: A low ALI was significantly associated with male gender, older age, a higher depth of tumor invasion, progressed TNM stage, and preoperative carcinoembryonic antigen (CEA) positivity. Both postoperative complications and severe complications occurred more frequently in the ALI-low group than in the ALI-high group (P < .001 and P < .001, respectively), especially postoperative complications in stage III patients (P < .001) and severe complications in stages II and III patients (P = .024 and P = .004, respectively). In addition, a low ALI was an independent predictor of a poor overall survival (hazard ratio: 2.30, 95% confidence interval: 1.52-3.50, P < .001) and relapse-free survival (hazard ratio: 1.73, 95% confidence interval: 1.22-2.44, P = .002), especially in older patients, and in patients without lymph node metastasis or severe postoperative complications. Conclusion:This study suggests that preoperative ALI may serve as a novel independent predictive index for severe postoperative complications and recurrence in CRC patients after curative resection.

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Clinical significance of advanced lung cancer inflammation index, a nutritional and inflammation index, in gastric cancer patients after surgical resection: A propensity score matching analysis

Cited by 27 publications

References 37 publications

Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study

Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study

Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma

The advanced lung cancer inflammation index is a novel independent prognosticator in colorectal cancer patients after curative resection

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