Clinical significance of abnormal prothrombin(PIVKA-II) in patients with hepatocellular carcinoma. Detection of PIVKA-II by ELISA using anti-PIVKA-II monoclonal antibody.

康彦, 松木; 圭二, 三田村; 高史, 山口; 直見, 田中; 達也, 相川; 陽, 高橋; 道泰, 矢倉; 英治, 原田; 明, 大林; 俊明, 大菅

doi:10.2957/kanzo.28.1073

Acta hepatologica Japonica

1987

DOI: 10.2957/kanzo.28.1073

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Clinical significance of abnormal prothrombin(PIVKA-II) in patients with hepatocellular carcinoma. Detection of PIVKA-II by ELISA using anti-PIVKA-II monoclonal antibody.

松木康彦¹,

三田村圭二²,

山口高史³

et al.

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1989

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Abnormal plasma prothrombin (PIVKA-II) levels in hepatocellular carcinoma

Kawaguchi

1989

The Japanese Journal of Surgery

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The concentration of abnormal prothrombin, or the protein induced by vitamin K absence or antagonist II (PIVKA-II) in 102 patients with hepatic disorders was measured by an enzyme immunoassay method. The concentration of PIVKA-II in the plasma was elevated in 11 out of 18 patients with hepatocellular carcinoma and also in a patient with hepatoblastoma. There was no correlation between serum alpha-fetoprotein and plasma PIVKA-II levels. The PIVKA-II level was normal in 11 patients who had metastatic carcinoma or cholangiocellular carcinoma. Moreover, benign diseases of the liver did not cause an elevation in PIVKA-II. PIVKA-II might be an useful marker of hepatocellular carcinoma because, like alpha-fetoprotein, its level changes in close relation to the effects of treatment.

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Abnormal plasma prothrombin (PIVKA-II) levels in hepatocellular carcinoma

Kawaguchi

1989

The Japanese Journal of Surgery

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Clinical significance of abnormal prothrombin(PIVKA-II) in patients with hepatocellular carcinoma. Detection of PIVKA-II by ELISA using anti-PIVKA-II monoclonal antibody.

Cited by 1 publication

References 10 publications

Abnormal plasma prothrombin (PIVKA-II) levels in hepatocellular carcinoma

Abnormal plasma prothrombin (PIVKA-II) levels in hepatocellular carcinoma

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