Clinical Significance and Reproducibility of New Arterial Distensibility Index

Tissue Doppler Echocardiography for Predicting Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

“…However, that study was performed by measuring carotid-femoral pulse wave velocity, which though noninvasive requires a complicated technique. Our data demonstrated similar results using CAVI, which has been recently established as a marker of arterial stiffness and is widely used in clinical settings (Kubozono et al 2007;Takaki et al 2007;Kadota et al 2008;Takaki et al 2008). Mizuguchi et al (2007) demonstrated that CAVI was more closely related to the LV diastolic functional parameter (early diastolic strain rate) obtained from tissue Doppler echocardiography than that obtained from conventional Doppler echocardiography, and concluded that arterial stiffness was associated with LV relaxation during early diastole.…”

Noninvasive indices of arterial stiffness in hemodialysis patients

“…17 Several studies have shown the usefulness of CAVI for detecting atherosclerotic disease, 23,24 with one study in 67 HD patients using multiple regression analysis to reveal that the high-molecular weight adiponectin to baPWV and CAVI in HD patients K Ueyama et al total adiponectin ratio was an independent determinant of PWV and CAVI. 25 Takaki et al 26 compared baPWV and CAVI in 130 patients with chest pain syndrome and concluded that CAVI was superior to baPWV as a parameter of arterial stiffness.…”

“…PWV was calculated by dividing the distance from the aortic valve to the ankle artery by the sum of the difference between the time the pulse waves were transmitted to the brachium and the time the same waves were transmitted to the ankle, and the time difference between the second heart sound on the phonocardiogram and the notch of the brachial pulse waves. [15][16][17] To minimize cuff inflation effects on blood flow dynamics, pulse waves were measured with the cuffs inflated to lower than diastolic pressure (50 mm Hg). The extremity blood pressure was then measured by oscillometry.…”

“…16,17,19 Analysis of blood samples Blood samples were obtained after an overnight fast on the morning of the day baPWV and CAVI were measured. The serum concentrations of creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), calcium (Ca), phosphoric acid (P), parathyroid hormone (PTH), total cholesterol, triglyceride (TG) and highdensity lipoprotein cholesterol (HDL-C) were measured using standard laboratory procedures.…”

“…CAVI is adjusted for BP based on the stiffness parameter b and therefore measures arterial stiffness independent of BP. [15][16][17] We have reported previously that CAVI showed a weaker correlation with systolic BP (SBP) than baPWV and was not affected by changes in BP during measurement. 9 There is also evidence that CAVI reflects histological arterial fibrosis and is a useful clinical marker for evaluating arterial stiffness in HD patients.…”