Clinical significance and prognostic value of Triosephosphate isomerase expression in gastric cancer

Abstract

Triosephosphate isomerase (TPI) is highly expressed in many human cancers and is involved in migration and invasion of cancer cells. However, TPI clinicopathological significance and prognostic value in gastric cancer (GC) are not yet well defined. The aim of the present work was to evaluate TPI expression in GC tissue and its prognostic value in GC patients.TPI expression was analyzed in 92 primary GC tissues and 80 adjacent normal mucosa tissues from GC patients undergoing gastrectomy by immunohistochemical analysis of tissue microarrays (TMAs). Univariate and multivariate analyses were performed to investigate TPI prognostic significance in GC patients.Immunohistochemical staining score showed that TPI expression in cancer tissues was significantly higher than in adjacent normal mucosa (P < .001). Univariate analysis revealed that TPI expression, depth of invasion, lympho node metastasis, tumor node metastasis (TNM) stage, and tumor diameter were associated with negative prognostic predictors for overall survival in GC patients (P < .05). High TPI expression represented a significant predictor of shorter survival in GC patients with positive lymphatic metastasis (P = .022) and tumor diameter >5 cm (P = .018). Cox multivariate analysis identified TPI expression, TNM stage, and tumor diameter as independent prognostic factors in GC patients.TPI expression might be considered as a novel prognostic factor to evaluate GC patients’ survival.

Triose‐phosphate isomerase is a novel target of miR‐22 and miR‐28, with implications in tumorigenesis

“…Our western blot result indicated that the TPI protein is significantly upregulated in the tumor samples relative to the adjacent normal tissue. Similar to our observation, the overexpression of the TPI has been reported in various human tumors (Altenberg & Greulich, ) and importantly linked to the progression, migration, and invasion of the tumor cells (T. Chen et al, ). Furthermore, our data established that the post‐transcriptional regulation seems to be the likely mechanism for the upregulation of the TPI protein.…”

An Integrated Meta-Analysis of Secretome and Proteome Identify Potential Biomarkers of Pancreatic Ductal Adenocarcinoma

“…Proteomic analysis of sera from pancreatic cancer patients showed TPI1 as one of the most abundant proteins in patients with poor survival before and after chemotherapy and could be further investigated as a prognostic marker as its levels gradually increase as the disease progresses [123]. The prognostic value TPI1 was also evaluated in gastric cancer, where patients with higher TPI1 expression had lower overall survival [124].…”

Therapeutic Targeting of Cancer Metabolism with Triosephosphate Isomerase

“…However, in recent years, the molecular mechanisms of the relationship between TPI and cancer progression have been started to be investigated. The results of the studies provide strong evidence that TPI enzyme may be involved in tumor progression, drug resistance, invasion and metastasis …”

“…In one of the recent studies, TPI has been defined as a potential tumor marker in gastric cancer . Chen et al .…”

“…They have also reported that the downregulation of TPI shows an antiproliferative effect via arresting the cell cycle in G2 phase. In another study conducted by the same researchers, the clinicopathological role of TPI and the relationship between TPI and prognosis in gastric cancer were investigated . The results showed that patients with higher TPI expression levels have shorter survival when compared to patients with lower TPI expression.…”