Clinical Significance and Prognostic Value of SOX2 Protein Expression in Patients With Oral Squamous Cell Carcinoma

Ghazaghi, Faezeh; Saffar, Hiva; Yazdani, Farzad; Etebarian, Arghavan

doi:10.1097/pai.0000000000000942

Cited by 3 publications

(2 citation statements)

References 35 publications

(74 reference statements)

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“…29,30 Furthermore, Ghazaghi and colleagues also observed a correlation between increased SOX2 expression and larger tumor sizes, more lymph node metastasis, and lower survival rates in oral squamous cell carcinoma patients. 31 Regarding SOX2, our study exhibited a low expression in cases with unpleasant outcomes, without correlation to neither survival rate nor clinicopathologic features. Solely an association of lower SOX2 expression with higher histopathologic grade was found in MEC patients.…”

Section: High Expression Low Expressionmentioning

confidence: 56%

“…Most studies regarding the role of SOX2 in different types of cancers such as malignant colorectal tumors, breast cancer, and oral squamous cell carcinoma demonstrated that the increase in expression of SOX2 has a relationship with tumorigenesis and aggressive behavior of most of the malignant tumors, which can lead to the poor prognosis of the patients 29,30. Furthermore, Ghazaghi and colleagues also observed a correlation between increased SOX2 expression and larger tumor sizes, more lymph node metastasis, and lower survival rates in oral squamous cell carcinoma patients 31…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Significance of Cancer Stem Cell Markers in Patients With Salivary Gland Carcinomas

Sadeghi

Saffar²,

Taheri³

et al. 2022

Applied Immunohistochemistry &Amp; Molecular Morphology

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Objectives: Cancer stem cells (CSCs) are a small group of cells resistant to therapy and play a major role in tumor progression, recurrence, and poor clinical outcomes of patients. This study aimed to evaluate the association of CSC markers with clinicopathologic features and survival in patients with salivary gland carcinomas (SGCs). Materials and Methods:The medical records of 48 patients affected by mucoepidermoid carcinoma (MEC) and 47 patients with adenoid cystic carcinoma (AdCC) were reviewed retrospectively. SOX2, CD133, and CD44 expression was appraised by immunohistochemistry and statistically analyzed to weigh the correlation between these markers and patients' clinicopathologic features and tumor outcomes. Results:In AdCC patients showing poor outcomes, a trend toward a high expression of CD133 and CD44 and low expression of SOX2 was observed, while in MEC patients experiencing the same outcomes, there was a trend toward a high expression of CD44 and low expression of CD133 and SOX2. Only the increase of MEC histopathologic grade was statistically significant with decreased SOX2 expression. Distant metastasis in AdCC patients, tumor grade, lymph node involvement, and local recurrence in MEC patients had significant correlations with patients' survival. Conclusion:Besides the significant association between low SOX2 expression and higher grades of MEC, we found no statistically significant correlation between the studied CSC markers and patients' survival or clinicopathologic features. Therefore, a larger sample size with long-term follow-up is beneficial for thorough investigations toward the main role of CSCs in patients with SGCs.

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Section: High Expression Low Expressionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%