Clinical significance and applications of oscillometry

Kaminsky, David A.; Simpson, Shannon J.; Berger, Kenneth I.; Calverley, Peter M.A.; Melo, Pedro Lopes de; Dandurand, Ronald; Dellacà, Raffaele L.; Farah, Claude S.; Farré, Ramón; Hall, Graham; Ioan, Iulia; Irvin, Charles G.; Kaczka, David W.; King, Gregory G.; Kurosawa, Hájíme; Lombardi, Enrico; Maksym, Geoffrey N.; Marchal, François; Oostveen, Ellie; Oppenheimer, Beno W.; Robinson, Paul D.; Berge, Maarten van den; Thamrin, Cindy

doi:10.1183/16000617.0208-2021

Cited by 92 publications

(89 citation statements)

References 235 publications

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“…One study showed that there was a poor correlation between the lung function index of SAD and gas trapping (FVC and RV/TLC) ( Sorkness et al, 2008 ), and its ability to evaluate SAD may be questioned. Compared with spirometry, the frequency dependence of R rs of IOS was commonly quantified as the difference R 5 -R 20 ( Kaminsky et al, 2022 ). A recent study confirmed that R 5 -R 20 was a direct indicator of anatomical narrowing in the small airways through lung computational models ( Foy et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Discordant Spirometry and Impulse Oscillometry Assessments in the Diagnosis of Small Airway Dysfunction

Peng

Zhao

et al. 2022

Front. Physiol.

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Background and objective: Spirometry is commonly used to assess small airway dysfunction (SAD). Impulse oscillometry (IOS) can complement spirometry. However, discordant spirometry and IOS in the diagnosis of SAD were not uncommon. We examined the association between spirometry and IOS within a large cohort of subjects to identify variables that may explain discordant spirometry and IOS findings.Methods: 1,836 subjects from the ECOPD cohort underwent questionnaires, symptom scores, spirometry, and IOS, and 1,318 subjects were examined by CT. We assessed SAD with R5-R20 > the upper limit of normal (ULN) by IOS and two of the three spirometry indexes (maximal mid-expiratory flow (MMEF), forced expiratory flow (FEF)50%, and FEF75%) < 65% predicted. Multivariate regression analysis was used to analyze factors associated with SAD diagnosed by only spirometry but not IOS (spirometry-only SAD) and only IOS but not spirometry (IOS-only SAD), and line regression was used to assess CT imaging differences.Results: There was a slight agreement between spirometry and IOS in the diagnosis of SAD (kappa 0.322, p < 0.001). Smoking status, phlegm, drug treatment, and family history of respiratory disease were factors leading to spirometry-only SAD. Spirometry-only SAD had more severe emphysema and gas-trapping than IOS-only SAD in abnormal lung function. However, in normal lung function subjects, there was no statistical difference in emphysema and gas-trapping between discordant groups. The number of IOS-only SAD was nearly twice than that of spirometry.Conclusion: IOS may be more sensitive than spirometry in the diagnosis of SAD in normal lung function subjects. But in patients with abnormal lung function, spirometry may be more sensitive than IOS to detect SAD patients with clinical symptoms and CT lesions.

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Section: Discussionmentioning

confidence: 99%

Discordant Spirometry and Impulse Oscillometry Assessments in the Diagnosis of Small Airway Dysfunction

Peng

Zhao

et al. 2022

Front. Physiol.

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“…It does not require the patient's special cooperation and is simple, noninvasive, repeatable, and provides comprehensive respiratory physiological parameters. It is especially suitable for people aged 3 and above [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Reference values of impulse oscillometry (IOS) for healthy Chinese children aged 4–17 years

Zhang

Shi

et al. 2022

Respir Res

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Objective To establish the predicted value of pulmonary function determined by impulse oscillometry (IOS) in children (4–17 years old) in China. Methods A total of 6270 healthy children aged 4–17 years in China were included. The Master Screen IOS pulmonary function device (Jaeger Co, Germany) was used to detect the respiratory impedance (Zrs), resonant frequency (Fres), respiratory system resistance (Rrs) and respiratory system reactance (Xrs) at various oscillation frequencies, and the indices above were analysed. Stepwise multivariate regression was used to establish the regression equation of related parameters of IOS in different sexes, ages, height, and weight. Results The differences in the main IOS parameters between different age stages were statistically significant regardless of sex (P < 0.05). The stepwise multivariate regression analysis showed that IOS parameters were related to height, age, and weight, and most IOS parameters were most closely related to height (the absolute value of the regression coefficient was the largest). With increasing age and height, the values of Z5, R5, R20, R5–R20, and Fres decreased, while the value of X5 increased. Through height, age, and weight, we obtained the normal predicted values equation of children’s IOS parameters. Compared with the other reference equations, our reference equation is more suitable for Chinese children. Conclusions The study revealed the reference values of IOS parameters in healthy Chinese children. In the evaluation of results for lung function measurements, this predicted value equation is more consistent with the characteristics of Chinese children than other reference equations. Clinical Trial: ChiCTR: 1800019029.

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“…In particular, impulse oscillometry (IOS) is an effort-independent modality based on the well-described forced oscillation technique (FOT) ( 9 , 10 ) and has emerged as a method to measure pulmonary function in both children and adults ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Small Airways: The “Silent Zone” of 2021 GINA Report?

Cottini¹,

Lombardi

Passalacqua

et al. 2022

Front. Med.

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Asthma is a chronic disease, affecting approximately 350 million people worldwide. Inflammation and remodeling in asthma involve the large airways, and it is now widely accepted that the small airways (those with an internal diameter <2 mm) are involved in the pathogenesis of asthma and are the major determinant of airflow obstruction in this disease. From a clinical perspective, small airways dysfunction (SAD) is associated with more severe bronchial hyperresponsiveness, worse asthma control and more exacerbations. Unlike the GOLD guidelines which, in their definition, identify COPD as a disease of the small airways, the Global Initiative for Asthma (GINA) guidelines do not refer to the prevalence and role of SAD in asthmatic patients. This decision seems surprising, given the growing body of compelling evidence accumulating pointing out the high prevalence of SAD in asthmatic patients and the importance of SAD in poor asthma control. Furthermore, and remarkably, SAD appears to possess the characteristics of a treatable pulmonary trait, making it certainly appealing for asthma control optimization and exacerbation rate reduction. In this mini-review article, we address the most recent evidence on the role of SAD on asthma control and critically review the possible inclusion of SAD among treatable pulmonary traits in international guidelines on asthma.

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Clinical significance and applications of oscillometry

Cited by 92 publications

References 235 publications

Discordant Spirometry and Impulse Oscillometry Assessments in the Diagnosis of Small Airway Dysfunction

Discordant Spirometry and Impulse Oscillometry Assessments in the Diagnosis of Small Airway Dysfunction

Reference values of impulse oscillometry (IOS) for healthy Chinese children aged 4–17 years

Small Airways: The “Silent Zone” of 2021 GINA Report?

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