Clinical significance and antibiotic susceptibilities of nontuberculous mycobacteria from patients in Crete, Greece

Gitti, Zoe; Mantadakis, Elpis; Maraki, Sofia; Samonis, George

doi:10.2217/fmb.11.91

Cited by 27 publications

(19 citation statements)

References 32 publications

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“…NTM-PD incidence in Croatia is low compared to TB incidence as well as to NTM-PD incidence in North-Western Europe 4,26-28 , North America 11,17,22,29,30 , Australia 31 and Japan. 32 Similar disease incidence was recorded in Greece 33,34 and Sao Paulo region, Brasil. 35 Generally, the prevalence of NTM-PD in Europe is substantially lower than in North America, Australia and Japan.…”

Section: Incidence and Prevalence Of Ntm-pd In Croatiasupporting

confidence: 58%

Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology

Janković¹,

Sabol²,

Žmak³

et al. 2016

int j tuberc lung dis

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Section: Incidence and Prevalence Of Ntm-pd In Croatiasupporting

confidence: 58%

Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology

Janković¹,

Sabol²,

Žmak³

et al. 2016

int j tuberc lung dis

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“…Although tigecycline has consistently demonstrated excellent activity in vitro against clinical isolates of both tetracycline-susceptible and tetracycline-resistant M. abscessus and M. chelonae , 9,28–30 few reports of clinical experience with tigecycline for the treatment of RGM infections are found in the medical literature. 29,31–38 Garrison et al 33 reported three cases of M. abscessus surgical wound-site infections associated with solid organ transplants.…”

Section: Discussionmentioning

confidence: 99%

Clinical experience in 52 patients with tigecycline-containing regimens for salvage treatment of Mycobacterium abscessus and Mycobacterium chelonae infections

Wallace

Dukart

Brown‐Elliott

et al. 2014

Journal of Antimicrobial Chemotherapy

149

117

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ObjectivesWe report the largest clinical experience using tigecycline-containing regimens for salvage treatment of patients with Mycobacterium abscessus and Mycobacterium chelonae.Patients and methodsData were collected from 52 patients on emergency/compassionate use (n = 38) or two open-label studies (n = 7 patients each). Based on information that was available, 46 (88.5%) of the subjects received antibiotic therapy prior to treatment with tigecycline. Treatment groups were evaluated based on length of tigecycline therapy (<1 and ≥1 month). ClinicalTrials.gov identifiers: Study 205, NCT00600600 and Study 310, NCT00205816.ResultsThe most commonly used concomitant antimicrobials were macrolides, amikacin and linezolid. Pulmonary disease was the most common presentation (36/52; 69.2%), and 58.3% of these patients had underlying cystic fibrosis. The majority were M. abscessus complex (n = 30) or M. chelonae/abscessus (n = 4). With therapy ≥1 month (mean, 255.0 ± 265.7 days), 10/15 patients (66.7%) with cystic fibrosis and 16/26 (61.5%) overall were considered improved. Skin/soft-tissue/bone infections were the most common extrapulmonary infections. With therapy ≥1 month (mean, 143 ± 123 days), 9/12 patients (75.0%) were considered improved. Nine of the 16 cases reported as failures regardless of site of infection occurred in patients who stopped treatment due to adverse events. There were eight deaths; none was related to tigecycline.ConclusionsTigecycline given for ≥1 month as part of a multidrug regimen resulted in improvement in >60% of patients with M. abscessus and M. chelonae infections, including those with underlying cystic fibrosis, despite failure of prior antibiotic therapy. Adverse events were reported in >90% of cases, the most common being nausea and vomiting.

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“…Two additional studies on the incidence of NTM in Greece were found in the literature: one conducted in Larissa, central Greece [19], and one in Crete island [20]. Notably, all three are hospital-based studies, which highlights the lack of large-scaled epidemiological studies for NTM in Greece.…”

Section: Discussionmentioning

confidence: 99%

The Epidemiology of Pulmonary Nontuberculous Mycobacteria: Data from a General Hospital in Athens, Greece, 2007–2013

et al. 2014

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Background. The epidemiology of pulmonary nontuberculous mycobacteria (NTM) in Greece is largely unknown. Objectives. To determine the incidence and the demographic, microbiological, and clinical characteristics of patients with pulmonary NTM infection and pulmonary NTM disease. Methods. A retrospective review of the demographic, microbiological, and clinical characteristics of patients with NTM culture-positive respiratory specimens from January 2007 to May 2013. Results. A total of 120 patients were identified with at least one respiratory NTM isolate and 56 patients (46%) fulfilled the microbiological ATS/IDSA criteria for NTM disease. Of patients with adequate data, 16% fulfilled the complete ATS/IDSA criteria for NTM disease. The incidence of pulmonary NTM infection and disease was 18.9 and 8.8 per 100.000 inpatients and outpatients, respectively. The spectrum of NTM species was high (13 species) and predominated by M. avium-intracellulare complex (M. avium (13%), M. intracellulare (10%)), M. gordonae (14%), and M. fortuitum (12%). The ratio of isolation of NTM to M. tuberculosis in all hospitalized patients was 0.59. Conclusions. The first data on the epidemiology of pulmonary NTM in Athens, Greece, are presented. NTM infection is common in patients with chronic respiratory disease. However, only a significantly smaller proportion of patients fulfill the criteria for NTM disease.

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Clinical significance and antibiotic susceptibilities of nontuberculous mycobacteria from patients in Crete, Greece

Abstract: Our study is the first to describe the clinical significance, risk factors and susceptibility patterns of NTM isolates in a Greek population.

Cited by 27 publications

References 32 publications

Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology

Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology

Clinical experience in 52 patients with tigecycline-containing regimens for salvage treatment of Mycobacterium abscessus and Mycobacterium chelonae infections

The Epidemiology of Pulmonary Nontuberculous Mycobacteria: Data from a General Hospital in Athens, Greece, 2007–2013

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