Clinical severity and epithelial endotypes in chronic rhinosinusitis

Abstract

Inflammatory mediators of the epithelium in CRS has some correlation with traditional measures of disease burden. Certain epithelial profiles may predict highly dysfunctional epithelial barriers and prospective evaluation of the clinical outcomes from interventions is required. Future endotyping of the epithelium in CRS may be able to provide prognostic information.

Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma

“…31 Moreover, our observations further support the primordial role of CCL26 in the pathogenesis of eosinophilic diseases, adding severe eosinophilic asthma to atopic dermatitis, chronic rhinosinusitis, eosinophilic esophagitis, and Churg-Strauss vasculitis. [24][25][26][27][28][29][30] (Fig 4, A), a patient with mild asthma (Fig 4, B), and a patient with severe eosinophilic asthma (Fig 4, C). D, Computed scores of CCL26 staining intensity in bronchial epithelium of asthmatic patients were compared with those of healthy control subjects.…”

“…23 Increased CCL26 levels are found in patients with eosinophilic diseases, such as atopic dermatitis, chronic rhinosinusitis, eosinophilic esophagitis, and ChurgStrauss vasculitis, suggesting a primordial role for CCL26 in the pathogenesis of eosinophilic diseases. [24][25][26][27][28][29][30] Increased CCL24 and CCL26 mRNA levels were recently documented in airway epithelial brushings of asthmatic patients. 31 This was associated with lower lung function, increased sputum eosinophil counts, and asthma exacerbation events.…”

Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration

“…Recent studies in the field also identified other contributors to IL-17A production, mainly in the innate arm of the immune system. IL-17A plays protective roles in host defense against certain pathogens at epithelial and mucosal barriers [11]. In addition to its role in bacterial immunity, IL-17A is involved in controlling fungal infection [2,21].…”

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

“…[68]. A higher expression of IL-25 mRNA has been reported in sinus mucosa from CRSwNP patients compared with CRSsNP patients and controls, and a positive correlation is found between IL-25 expression and preoperative CT score [69].…”

“…Eotaxins are highly elevated in NPs from CRSwNP patients compared with tissue from CRSsNP patients and controls [45•, 89]. A positive correlation has been found between eotaxin-3 (CCL26) expression in sinus mucosa and preoperative CT score in patients with CRSwNP and CRSsNP [69]. Higher plasma levels of eotaxin-1 (CCL11) and RANTES have been reported in patients with CRSwNP compared with healthy controls.…”