Clinical Scales of Cerebellar Ataxias

Abstract

Clinical scales represent an important tool not only for the initial grading/scoring of disease and assessment of progression but also for the quantification of therapeutic effects in clinical trials. There are several scales available for the clinical evaluation of cerebellar symptoms. While some scales have been developed and evaluated for specific cerebellar disorders such as Friedreich ataxia (FA), others reliably capture cerebellar symptoms with no respect to the underlying etiology. Each scale has its strengths and weaknesses. Extensive scales are certainly useful for thorough documentation of specific features of certain phenotypes, but this gain of information is not always essential for the purpose of a study. Therefore, compact and manageable scales like SARA or BARS are often preferred compared to more complex scales in observational and therapeutic studies.