Clinical role of vitamin D in prognosis of otitis media with effusion

Dündar, Yusuf; Akcan, Hümeyra Bayram; Uluat, Ahmet; Cebeci, Derya; Sungur, Mehmet Alı; Ünlü, İlhan

doi:10.1016/j.ijporl.2017.11.030

Cited by 18 publications

(16 citation statements)

References 30 publications

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“…Vitamin D levels of < 20 ng/mL, 20 -32 ng/mL, and 32 -100 ng/mL were considered as deficient, insufficient, and adequate, respectively (30). Type A tympanogram was accepted as normal, and types B and C as SOM (3,31). The checklist data were entered into SPSS V. 22, and the relationship between SOM and vitamin D deficiency was studied.…”

Section: Methodsmentioning

confidence: 99%

Relationship Between Serum Vitamin D Levels and Serous Otitis Media in Children with Adenoid Hypertrophy Based on Age

Abhari

Majidinia

Beyranvand

et al. 2020

Thrita

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Background: Serous Otitis Media (SOM) is one of the most common diseases of children that can lead to hearing loss and imbalance. Recently, the role of vitamin D has been identified in strengthening and regulating the immune system. Moreover, vitamin D supplementation has been recognized to improve the immune response against upper respiratory infection and pathogen overgrowth. Methods: A cross-sectional study was performed on 89 children aged 1 - 15 years with adenoid hypertrophy who met the inclusion criteria. The serum vitamin D level was compared between the two groups of children with and without SOM. Results: The mean age of the target children was 69.57 ± 25.65 months. The mean serum vitamin D level was 23.86 ± 12.7 in all patients. The mean serum vitamin D level was 24.7 ± 13.1 and 22.9 ± 12.2 in patients with and without SOM (based on tympanometry), respectively, yet the difference was not statistically significant. However, the difference was significant between the two groups of children with the age of < 84 months and > 84 months (P = 0.05). Conclusions: The role of vitamin D was identified in increasing the incidence of SOM in children older than 84 months with adenoid hypertrophy. In older children, the timely diagnosis and treatment of vitamin D deficiency can prevent severe SOM complications, which can save a lot of costs for families and the health system.

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Section: Methodsmentioning

confidence: 99%

Relationship Between Serum Vitamin D Levels and Serous Otitis Media in Children with Adenoid Hypertrophy Based on Age

Abhari

Majidinia

Beyranvand

et al. 2020

Thrita

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“…They proposed that COME could be reduced by increasing serum 25(OH)D concentration through increased sun exposure, and higher dietary intake or vitamin D supplementation [52]. A more recent study strongly suggests that there is a significant association between vitamin D deficiency and follow-up outcomes of OME, as well as a strong effect of vitamin D on OME prognosis [53].…”

Section: Otitis Mediamentioning

confidence: 99%

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

2019

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Purpose Respiratory tract infections (RTIs) are a major cause of illness worldwide and the most common cause of hospitalization for pneumonia and bronchiolitis. These two diseases are the leading causes of morbidity and mortality among children under 5 years of age. Vitamin D is believed to have immunomodulatory effects on the innate and adaptive immune systems by modulating the expression of antimicrobial peptides, like cathelicidin, in response to both viral and bacterial stimuli. The aim of this review is to summarize the more recently published data with regard to potential associations of 25-hydroxyvitamin D [25(OH)D] with infectious respiratory tract diseases of childhood and the possible health benefits from vitamin D supplementation. Methods The literature search was conducted by using the PubMed, Scopus, and Google Scholar databases, with the following keywords: vitamin D, respiratory tract infection, tuberculosis, influenza, infancy, and childhood. Results Several studies have identified links between inadequate 25(OH)D concentrations and the development of upper or lower respiratory tract infections in infants and young children. Some of them also suggest that intervention with vitamin D supplements could decrease both child morbidity and mortality from such causes. Conclusions Most studies agree in that decreased vitamin D concentrations are prevalent among most infants and children with RTIs. Also, normal to high-serum 25(OH)D appears to have some beneficial influence on the incidence and severity of some, but not all, types of these infections. However, studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses.

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“…[14] It increases the antimicrobial activity of freshly isolated monocytes and decreases T-cell stimulation and macrophage inflammation. [15] Chemotactic and phagocytic effects of monocytes and macrophages can be increased by vitamin D. Also, an increment in the synthesis of antimicrobial peptides, defensins and cathelicidin can be presented from natural killer cells and respiratory tract epithelial cells in an enriched active vitamin D environment. [15] In addition, vitamin D causes the upregulation of calprotectin and S100 protein levels, which contribute significantly to the functions of the natural immune system.…”

Section: Vitamin D and Immunoregulationmentioning

confidence: 99%

“…[15] Chemotactic and phagocytic effects of monocytes and macrophages can be increased by vitamin D. Also, an increment in the synthesis of antimicrobial peptides, defensins and cathelicidin can be presented from natural killer cells and respiratory tract epithelial cells in an enriched active vitamin D environment. [15] In addition, vitamin D causes the upregulation of calprotectin and S100 protein levels, which contribute significantly to the functions of the natural immune system. [16] Vitamin D also has modulatory functions on a variety of cytokines that are considered to have an active role in the pathogenesis of many autoimmune diseases.…”

Section: Vitamin D and Immunoregulationmentioning

confidence: 99%

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The Role Of Vitamin D In Otolaryngological Diseases: Myth Or Truth

Bayram¹

2018

ENT Updates

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In the present review, we aimed to evaluate the role of vitamin D in otolaryngological diseases. Since the recognition of vitamin D as a steroid hormone, it has attracted clinicians as a research issue due to its unique and complicated functions in human body processes. Numerous studies have investigated the association between vitamin D and human diseases, including in the otolaryngological field. However, although vitamin D alterations may theoretically be involved in the pathogenesis of several otolaryngological diseases, a clear association has not been demonstrated due to inconsistent results from the studies to date. Further randomized controlled trials with large patient populations are required to determine the exact role of vitamin D in otolaryngological diseases.

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Clinical role of vitamin D in prognosis of otitis media with effusion

Cited by 18 publications

References 30 publications

Relationship Between Serum Vitamin D Levels and Serous Otitis Media in Children with Adenoid Hypertrophy Based on Age

Relationship Between Serum Vitamin D Levels and Serous Otitis Media in Children with Adenoid Hypertrophy Based on Age

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

The Role Of Vitamin D In Otolaryngological Diseases: Myth Or Truth

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