Clinical role of lung ultrasound for diagnosis and monitoring of COVID‐19 pneumonia in pregnant women

Buonsenso, Danilo; Raffaelli, Francesca; Tamburrini, Enrica; Biasucci, Daniele Guerino; Salvi, Silvia; Smargiassi, Andrea; Inchingolo, Riccardo; Scambia, Giovanni; Lanzone, Antonio; Testa, Americo; Moro, Francesca

doi:10.1002/uog.22055

Cited by 140 publications

(182 citation statements)

References 12 publications

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“…The other women are currently followed-up in our center: one is admitted for preeclampsia with no respiratory symptoms (currently 35 weeks of gestational age), two women have been discharged home after having developed respiratory symptoms (currently at 20 and 27 weeks of gestational age, respectively), and one asymptomatic (currently at 18 weeks of gestational age). 4 Clinical, microbiological, and epidemiological details of the two neonates are reported in ►Fig. 1 and ►Table 1.…”

Section: Resultsmentioning

confidence: 99%

Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2

et al. 2020

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Since its first description, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide with over 2 million cases reported and thousands of deaths. Every human is susceptible to the infection, and pregnant women are not spared. Although reports documented COVID-19 infections among pregnant women 1,2 and described the neonatal outcome relatively to early days of life, 3 to date, no information on late-onset infection in newborns to mother with SARS-CoV-2 contracted in pregnancy are available. AbstractObjective To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate postdischarge SARS-CoV-2 status of newborns to mothers with COVID-19 in pregnancy that, at birth, were negative to SARS-CoV-2. Study Design This is an observational study of neonates born to mothers with coronavirus disease 2019 .Results Seven pregnant women with documented SARS-CoV-2 infection have been evaluated in our institution. One woman had a spontaneous abortion at 8 weeks of gestational age, four women recovered and are still in follow-up, and two women delivered. Two newborns were enrolled in the study. At birth and 3 days of life, newborns were negative to SARS-CoV-2. At 2-week follow-up, one newborn tested positive although asymptomatic. Conclusion Our findings highlight the importance of follow-up of newborns to mothers with COVID-19 in pregnancy, since they remain at risk of contracting the infection in the early period of life and long-term consequences are still unknown.

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Section: Resultsmentioning

confidence: 99%

Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2

et al. 2020

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“…Finally, 24 studies, including a total of 324 pregnant women with COVID-19, met the eligibility criteria and were included in the review. These comprised nine case series 11,[19][20][21][22][23][24][25][26] , published between 4 March 2020 and 28 April 2020, and 15 case reports [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] , published between 25 March 2020 and 28 April 2020 ( 35 1 I r a n 2 7 1 0 3 0+ 3 1 1 0 0 0 1 0 Kelly (2020) 36 1 U S A N R 1 0 3 3 1 1 0 0 0 0 0 Lee (2020) 37 1 Korea 28 1 0 37 + 6 1 1 0 0 1 0 0 Lowe (2020) 38 1 Australia 31 1 0 40 + 2 1 1 0 0 0 0 0 Schnettler (2020) 39 1 reported on a total of 295 pregnant patients 11,19,[21][22][23][24][25][26] . Of these, 211 (71.5%) cases had laboratory-confirmed and 84 (28.5%) had clinically diagnosed COVID-19.…”

Section: Figure 1 Summarizes the Selection Of Articles For Inclusionmentioning

confidence: 99%

“…Of these, 211 (71.5%) cases had laboratory-confirmed and 84 (28.5%) had clinically diagnosed COVID-19. The 15 case reports [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] included a total of 20 pregnant patients with laboratory-confirmed COVID-19. We recorded data related to maternal and perinatal characteristics, and the clinical manifestations of COVID-19 at admission, including laboratory testing, treatment received and maternal, perinatal and neonatal outcome.…”

Section: Figure 1 Summarizes the Selection Of Articles For Inclusionmentioning

confidence: 99%

“…We recorded data related to maternal and perinatal characteristics, and the clinical manifestations of COVID-19 at admission, including laboratory testing, treatment received and maternal, perinatal and neonatal outcome. The majority of the cases originated from China 11,[21][22][23][24][25] , but cases from Australia (one case report) 38 , Canada and France (one case report) 40 , Korea (one case report) 37 , Iran (two case reports and one case series) 20,35,41 , Italy (one case series and one case report) 26,29 , Peru (one case report) , Spain (two case reports) 27,31 , Sweden (one case report) 30 , Turkey (one case report) 34 and USA (one case series and four case reports) 19,32,33,36,39 were also included. We differentiated cases that were laboratory-confirmed from those that were diagnosed clinically, but data from the two types of diagnosis were combined for presentation.…”

Section: Figure 1 Summarizes the Selection Of Articles For Inclusionmentioning

confidence: 99%

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Effect of coronavirus disease 2019 (COVID‐19) on maternal, perinatal and neonatal outcome: systematic review

Juan

Gil

Zeng

et al. 2020

Ultrasound in Obstet & Gyne

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Objective To evaluate the effect of coronavirus disease 2019 (COVID‐19) on maternal, perinatal and neonatal outcome by performing a systematic review of available published literature on pregnancies affected by COVID‐19. Methods We performed a systematic review to evaluate the effect of COVID‐19 on pregnancy, perinatal and neonatal outcome. We conducted a comprehensive literature search using PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure Database and Wan Fang Data up to and including 20 April 2020 (studies were identified through PubMed alert after that date). For the search strategy, combinations of the following keywords and medical subject heading (MeSH) terms were used: ‘SARS‐CoV‐2’, ‘COVID‐19’, ‘coronavirus disease 2019’, ‘pregnancy’, ‘gestation’, ‘maternal’, ‘mother’, ‘vertical transmission’, ‘maternal–fetal transmission’, ‘intrauterine transmission’, ‘neonate’, ‘infant’ and ‘delivery’. Eligibility criteria included laboratory‐confirmed and/or clinically diagnosed COVID‐19, patient being pregnant on admission and availability of clinical characteristics, including at least one maternal, perinatal or neonatal outcome. Exclusion criteria were non‐peer‐reviewed or unpublished reports, unspecified date and location of the study, suspicion of duplicate reporting and unreported maternal or perinatal outcomes. No language restrictions were applied. Results We identified a high number of relevant case reports and case series, but only 24 studies, including a total of 324 pregnant women with COVID‐19, met the eligibility criteria and were included in the systematic review. These comprised nine case series (eight consecutive) and 15 case reports. A total of 20 pregnant patients with laboratory‐confirmed COVID‐19 were included in the case reports. In the combined data from the eight consecutive case series, including 211 (71.5%) cases of laboratory‐confirmed and 84 (28.5%) of clinically diagnosed COVID‐19, the maternal age ranged from 20 to 44 years and the gestational age on admission ranged from 5 to 41 weeks. The most common symptoms at presentation were fever, cough, dyspnea/shortness of breath, fatigue and myalgia. The rate of severe pneumonia reported amongst the case series ranged from 0% to 14%, with the majority of the cases requiring admission to the intensive care unit. Almost all cases from the case series had positive computed tomography chest findings. All six and 22 cases that had nucleic‐acid testing in vaginal mucus and breast milk samples, respectively, were negative for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Only four cases of spontaneous miscarriage or termination were reported. In the consecutive case series, 219/295 women had delivered at the time of reporting and 78% of them had Cesarean section. The gestational age at delivery ranged from 28 to 41 weeks. Apgar scores at both 1 and 5 min ranged from 7 to 10. Only eight neonates had birth weight < 2500 g and nearly one‐third of neonates were transferred to the neonatal intensive care...

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“…Lung ultrasound has been suggested as a useful tool to detect lung involvement during COVID-19, particularly desirable for pregnant women. [1][2][3] We developed a specific single day training program to provide gynecologists/obstetricians, already skilled in ultrasound examination, the theoretical background for the recognition of the main lung ultrasound patterns. Feasibility of the program and its effectiveness by comparing the number of correct answers in pre and post-training results were evaluated.…”

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confidence: 99%

Effectiveness of rapid lung ultrasound training program for gynecologists and obstetricians managing pregnant women with suspected COVID‐19

Buonsenso

Moro

Inchingolo

et al. 2020

Ultrasound in Obstet & Gyne

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Letters to the Editor Effectiveness of rapid lung ultrasound training program for gynecologists and obstetricians managing pregnant women with suspected COVID-19 Lung ultrasound examination has been suggested as a useful tool with which to detect lung involvement during the COVID-19 pandemic, desirable particularly for pregnant women 1-3. We developed a specific single-day training program to provide gynecologists and obstetricians who are already skilled in ultrasound examination with the theoretical background required for recognition of normal and the main abnormal lung ultrasound patterns. The training program was developed at the

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Clinical role of lung ultrasound for diagnosis and monitoring of COVID‐19 pneumonia in pregnant women

Cited by 140 publications

References 12 publications

Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2

Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2

Effect of coronavirus disease 2019 (COVID‐19) on maternal, perinatal and neonatal outcome: systematic review

Effectiveness of rapid lung ultrasound training program for gynecologists and obstetricians managing pregnant women with suspected COVID‐19

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