Clinical Risk Factors Underlying the Occurrence of Retinal Vein Occlusion

Abstract

Retinal vein occlusion (RVO) is the second commonest cause of retinal vascular disorder just after diabetic retinopathy. RVO is associated with a wide variety of systemic and local complicating factors. In over half of the cases with RVO, the age of the disease onset is over 65 years. The most recognized risk factors for RVO are the senility and accompanying systemic vascular diseases. Additional risk factors include thrombophilic mutations, systemic inflammatory conditions and ophthalmic risk factors. The aim of this review is to outline clinical risk factors underlying the occurrence of RVO.

Central retinal vein occlusion associated with platelet activation

“…The mechanical pressure in the lamina cribrosa, hemodynamic disturbances, vessel wall alterations, and the changes within the blood constituents are possible factors for CRVO. 2 Systemic hypercoagulable factors including platelet activity may also impact as a triggering activity.…”

“…The mechanical pressure in the lamina cribrosa, hemodynamic disturbances, vessel wall alterations, and the changes within the blood constituents are possible factors for CRVO. 2 Systemic hypercoagulable factors including platelet activity may also impact as a triggering activity. Hayreh and colleagues 23 investigated routine hematological tests and some specific hematological parameters, such as platelet aggregation, antithrombin III, and α2 globulin in patients with RVO, to investigate hematological abnormalities in RVO patients.…”

“…1,2 Central retinal vein occlusion (CRVO) is a major cause of vision impairment and slightly more frequent in men than in women. 2 The exact pathogenesis of CRVO remains unclear and controversial; it has been suggested that multiple factors including local anatomical susceptibility, degenerative changes of the vessel walls, and abnormal hematological abnormalities may contribute to the development of vascular obstruction. 3 The alterations in platelet parameters may induce protrombotic status of the patient.…”

A Study of the Relation between Ocular Axial Length and Central Retinal Vein Occlusion at a Tertiary Care Hospital in Mumbai

“…This leads to resolution of clinical signs such as hemorrhages, cotton wool spots, and disc edema. [12] Such patients with resolved or treated macular edema were included in our study for comparison of ALs [ Figure 2].…”