Clinical risk factors of severity and molecular epidemiology of respiratory syncytial virus circulating in Kuala Lumpur, Malaysia: a retrospective study of 21 years

Abstract

Background: polymorphism within regulatory regions of immune response genes can affect the level of gene expression. Gamma interferon (INF-g) is a cytokine that plays an important role in immune response to infection of hepatitis B virus (HBV). The aim of this study is to explore the association between the two single nucleotide polymorphisms (SNPs) within promoter (at positions -611G/A,-56T/C) of the gamma interferon receptor1 gene (INFGR1) and susceptibility to chronic HBV infection.Methods: A total of 400 individuals were included in a casecontrol study of Iranian populations with chronic HBV infection and healthy control group. Genomic DNA from peripheral blood samples of 200 chronically HBV infected patients and 200 healthy controls were extracted by phenol-chloroform method and genotyping was performed by PCR-RFLP method also p<0.05 considered as significant.Results: The frequencies of INFGR1 genotypes on -56 position were 36/6% for TT and 43/5% for TC and 20% CC in case group and 20.9% TT and 51/7% TC and 27/4% CC for control group(p value: 0.002) and frequencies of INFGR1 genotypes on -611 position were 41% for AA and 57/5% for AG and 1/5% GG in case group and 37/8% AA and 53/7% AG and 8/5% GG for control group (p value: 0.006) . Significant difference was observed between case and control group.Conclusion: A number of single-nucleotide mutations have been identified in interferon gamma receptor and its signaling pathway that predispose to chronic HBV infection. There was association between INFGR1 polymorphism (promoter at positions -611G/A,-56T/C) and chronic HBV infection. This study suggested the possibility that INFGR1gene polymorphism beside host genetic factors can be important in determining an individual's susceptibility in the progress to chronic HBV infection. http://dx. Background:Dengue is the leading cause of mosquito-borne viral disease in the world, and dengue fever (DF) and dengue hemorrhagic fever (DHF) continue to increase and geographic range.

Influenza and Respiratory Syncytial viral infections in Malaysia: Demographic and Clinical perspective

“… 19 Similar results cited by other authors and mentioned that there were no significant differences in terms of gender and ethnicity between patients infected with different viruses. 20 It was observed that clinical symptoms caused by different respiratory viruses were similar. Statistical analysis showed no relationships between genotypes of influenza A with clinical symptoms.…”