Clinical review – Breast adenoid cystic carcinoma

Boujelbene, N.; Khabir, A.; Sozzi, Wendy Jeanneret; Mirimanoff, René-Olivier; Khanfir, K.

doi:10.1016/j.breast.2011.11.006

Cited by 67 publications

(85 citation statements)

References 30 publications

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“…Geschickter and Copeland referred to this tumor as 'adenocystic basal cell cancer of the breast' in 1945, acknowledging its eccrine gland origin and slow growth (10). ACC of the breast is a particularly rare tumor, comprising <0.1% of all breast malignancies (6), and it occurs mainly in women during their fifth and sixth decades of life (11). Consistent with the current literature, our patient was 66-year-old.…”

Section: Discussionsupporting

confidence: 81%

“…Consistent with the current literature, our patient was 66-year-old. The most common clinical manifestation of ACC of the breast is a soft mass, commonly located in the subareolar area (6), as was the case in our patient. Multiple cytoarchitectural patterns have been reported (cribriform, tubular, trabecular and solid), and a mixture of different growth patterns is generally observed (12).…”

Section: Discussionsupporting

confidence: 77%

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Rare imaging appearance of adenoid cystic carcinoma of the breast: A case report

Wang

Liu

et al. 2017

Molecular and Clinical Oncology

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Abstract. Adenoid cystic carcinoma (ACC) of the breast is a rare tumor comprising <0.1% of all breast malignancies. The present study reports the case of a 66-year-old woman who underwent multiple imaging techniques, including mammography, ultrasonography and magnetic resonance imaging (MRI). The patient reported gradual enlargement of a mass in the left breast. Mammography identified a high-density, irregular mass, with nipple retraction. Ultrasonography revealed an irregular, complex cystic and solid mass with an unclear margin in the subareolar region. The internal vascularity was seen on Doppler examination. The lesion on MRI was also mixed cystic and solid, with an irregular shape and irregular margins. The solid part of the lesion appeared heterogeneously isointense on T1-weighted imaging (WI) and a slightly high signal on T2WI, and exhibited internal septations with a low signal on T2WI. Following injection of contrast agent, the enhancement of the solid part was rapid and heterogeneous. The cystic parts of lesion appeared as high-signal on T1WI and T2WI. The tumor infiltrated the left nipple and adjacent skin. The patient underwent a left modified radical mastectomy with axillary lymph node dissection. The pathological examination confirmed the tumor as ACC of the left breast. The axillary lymph nodes were negative for tumor metastasis. Therefore, the differential diagnosis of mixed cystic and solid breast masses with unclear margins and internal septations on T2WI exhibiting delayed enhancement, must include ACC. IntroductionAdenoid cystic carcinoma (ACC) usually occurs in salivary glands, but it has also been described in other organs, including the breast, trachea, uterine cervix, larynx and Bartholin's glands (1-5). However, ACC of the breast is rare (6); thus, there are only a few published studies describing the findings of multiple imaging techniques, and non-specific imaging characteristics have been found on mammography and ultrasonography (7,8). The aim of this study was to present a rare case of proven ACC of the breast and describe its imaging characteristics. Case reportIn April 2016, a 66-year-old woman was admitted to the Sun Yat-sen Memorial Hospital (Guangzhou, China) with a mass in the left breast that had been present for 4 years. The patient reported gradual enlargement of this mass over the last 2 months. Breast examination revealed a palpable mass in the subareolar region measuring 5.0x5.0 cm, with nipple retraction. There was no abnormal nipple discharge or skin redness. Axillary and subclavicular lymph nodes were not palpable. Mammography identified a 6.8x5.0 cm, high-density, irregular mass, with nipple retraction (Fig. 1). Ultrasonography revealed an irregular mass sized 5.0x4.3x5.0 cm, without a clearly circumscribed margin, in the subareolar region. The internal echo of the mass was mixed cystic and solid, with partial enhancement of the posterior echo (Fig. 2). On Doppler examination, internal vascularity was seen. The patient underwent a contrast-enhanced bilateral breast ma...

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 77%

Rare imaging appearance of adenoid cystic carcinoma of the breast: A case report

Wang

Liu

et al. 2017

Molecular and Clinical Oncology

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“…(Defaud-Henon et al, 2010). Preoperative fine-needle aspiration cytology can be useful for the diagnosis (Boujelbene et al, 2012). Mammography X-ray and ultrasound and other imaging studies are all lacking specificity and may be misdiagnosed as benign lesions (Glazebrook et al, 2010).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Currently based on its low invasiveness and metastatic potential and good prognosis, breast ACC commonly used breast-conserving surgery. Local excision alone was performed occasionally in the past with recurrence rates varying from 6% to 37% (Boujelbene et al, 2012). At present, multiple authors recommend extended resection or quadrant resection with or without radiation therapy for margin negative tumors .…”

Section: Surgical Treatmentmentioning

confidence: 99%

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Current Status and Progress of Breast Adenoid Cystic Carcinoma

Zhai¹,

You²,

Zhang³

et al. 2017

cge

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Adenoid cystic carcinoma (ACC) of the breast is a rare subtype of breast cancer. Despite its triple-negative status, this tumor has a very good prognosis. Breast-conserving treatment including postoperative radiotherapy seems to be equivalent to mastectomy alone with respect to survival. Routine axillary lymph node staging is not recommended since lymph node metastases are extremely rare. The value of adjuvant systemic therapies is not established. Late relapses can occur, so long-term follow-up is mandatory for these patients.

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