Clinical Results of Drug-Coated Balloon Treatment in a Large-Scale Multicenter Korean Registry Study

Lee, Sang Yeub; Kim, Sang‐Wook; Hong, Young Joon; Koo, Bon Kwon; Bae, Jang‐Whan; Lee, Seung-Hwan; Yang, Tae Hyun; Park, Hun Sik; Choi, Si Wan; Lim, Do‐Sun; Kim, Soo–Joong; Jeong, Young Hoon; Lee, Hyun-Jong; Lee, Kwan Yong; Shin, Eun‐Seok; Kim, Ung; Kim, Moo Hyun; Nam, Chang Wook; Hur, Seung‐Ho; Kim, Doo Il

doi:10.4070/kcj.2021.0261

Cited by 7 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They reported 8.9% of patients had target lesion failure, and 7.1% had TLR at 12 months. 11 Long-term follow-up in our cases shows the risk of events after stent insertion across the SB is minimal. The proximal optimization technique using a non-compliant balloon (3.5x12mm at 12 atm) was done followed by final kissing balloon angioplasty, using two non-compliant balloons -left anterior descending artery (3x12mm), and left anterior descending artery to diagonal side branch (3x12mm) at sequentially at higher pressures (at 20 atm, D), followed by simultaneously at nominal pressures (at 12 atm).…”

Section: Discussionmentioning

confidence: 53%

Percutaneous coronary intervention with the staged mini culotte technique for ostial restenosis of the large side branch

Jariwala,

Kulkarni

2024

J Transcat Intervent

View full text Add to dashboard Cite

Understanding the anatomy and physiology of a bifurcation is crucial in today’s interventional field. The bifurcation lesion is one of the most challenging coronary conditions to treat percutaneously. Numerous interventional strategies have been investigated because of the high level of interest in these lesions, but the relatively poor procedural and long-term results. Improvements in stenting and other interventional procedures have reduced the likelihood of adverse clinical outcomes, by creating the most favorable environment for stents to do their work. Provisional stenting has been widely accepted as the initial interventional technique for coronary bifurcation lesions by the medical community for over 15 years. Restenosis of a major branch is possible after angioplasty of the main vessel using a provisional one-stent approach. Although side branch restenosis following bifurcation angioplasty is less common with modern bifurcation procedures, it still occurs in 5% of cases during angiographic follow-up for symptoms. In our case series of five patients, severe side-branch restenosis presented with recuring anginal symptoms, which required target vessel revascularization. By applying bifurcation principles, we improved the “staged mini culotte” part of the culotte bifurcation stent technique, making it more user-friendly, and reducing exposure to radiation and operating time.

show abstract

Section: Discussionmentioning

confidence: 53%

Percutaneous coronary intervention with the staged mini culotte technique for ostial restenosis of the large side branch

Jariwala,

Kulkarni

2024

J Transcat Intervent

View full text Add to dashboard Cite

show abstract

“…Patients presenting with early DES restenosis had a significantly greater clinical event rate than patients presenting with late DES restenosis at 12 months following treatment of DES-ISR with DCB. Recently, another large-scale clinical study aiming to show that Pantera Lux and SeQuent Please DCB therapy is effective and safe for use in a broad, real-world population was published in a Korean circulation journal [ 39 ]. In this study, a multicenter observational registry was created for DCB-treated patients in Korea, enrolling patients from 18 institutions between January 2009 and December 2017.…”

Section: Drug-coated Balloonmentioning

confidence: 99%

Treatment of Peripheral Artery Disease Using Injectable Biomaterials and Drug-Coated Balloons: Safety and Efficacy Perspective

et al. 2023

View full text Add to dashboard Cite

The possibility of injectable biomaterials being used in the therapy of peripheral artery disease (PAD) is investigated in this article. We conducted a thorough review of the literature on the use and efficacy of biomaterials (BMs) and drug-coated balloons (DCBs). These BMs included hydrogels, collagen scaffolds, and nanoparticles. These BMs could be used alone or in combination with growth factors, stem cells, or gene therapy. The treatment of peripheral artery disease with DCBs is increasingly common in the field of interventional angiology. Studies have been carried out to examine the effectiveness of paclitaxel-coated balloons such as PaccocathTM in lowering the frequency with which further revascularization operations are required. PCB angioplasty and angioplasty without paclitaxel did not significantly vary in terms of mortality, according to the findings of a recent meta-analysis that included the results of four randomized controlled studies. On the other hand, age was found to be a factor that predicted mortality. There was a correlation between the routine utilization of scoring balloon angioplasty along with DCBs and improved clinical outcomes in de novo lesions. In both preclinical and clinical testing, the SelutionTM DCB has demonstrated efficacy and safety, but further research is required to determine whether or not it is effective and safe over the long term. In addition, we reviewed the difficulties involved in bringing injectable BMs-based medicines to clinical trials, including the approval processes required by regulatory bodies. Injectable BMs have a significant amount of therapeutic promise for PAD, which highlights the need for more research and clinical studies to be conducted in this field. In conclusion, this research focuses on the potential of injectable BMs and DCBs in the treatment of PAD as well as the hurdles that must be overcome in order to translate these treatments into clinical trials. In this particular field, there is a demand for further research as well as clinical trials.

show abstract

“…The observed rates of TLR in this study were higher than the other studies. For instance, in a study by Lee et al, which involved 2,666 coronary artery lesions treated with DCB, TLR occurred in only 5.1% of their patients ( 14 ). Our study also demonstrated higher restenosis rates than that in the PEARL registry, a real-world analysis of DCB use in the Netherlands conducted by Vlieger et al In their study of 513 patients treated with DCB, the incidence of TLR was 11.7% in ISR lesions and 2.9% in de novo lesions ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Factors influencing coronary artery target lesion revascularization after drug-coated balloon angioplasty

Undarsa,

Saboe,

Tiksnadi

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundConcerns regarding restenosis after treatment with drug-coated balloons (DCB) remain. We aimed to identify the incidence of target lesion revascularization (TLR) and explore clinical, procedural, and other factors influencing it.MethodsSingle-center retrospective analysis of a prospective cohort PCI registry study included 80 patients (100 lesions) who underwent successful DCB angioplasty between January 2020 and October 2023 and follow-up angiography within 2 years of either planned or unplanned reason. Incidence and factors associated with TLR were analyzed.ResultsAngiographic evaluation was conducted within a median of 151 days (interquartile range: 109 days). During index procedure, 54% were complex lesions. Intravascular imaging (IVI) was performed in 80% of lesions. TLR occurred in 11% of the lesions and was less frequent in the IVI group compared to the angiography-alone group [6.3 vs. 54.5%; odds ratio: 0.156, 95% confidence interval (CI): 0.042–0.580; p = 0.002]. No association was found between baseline and lesion characteristics, lesion complexity, plaque morphology, pre-dilatation procedure balloon type, maximal inflation pressure, or length of DCB between the groups (p > 0.05). Multivariate analysis revealed that IVI utilization was independently associated with a lower TLR rate (adjusted odds ratio: 0.116, 95% CI: 0.020–0.669; p = 0.016).ConclusionIn DCB angioplasty, only IVI use exhibited a significant difference in the TLR rate among baseline lesion characteristics and lesion preparation and was independently associated with a lower TLR rate.

show abstract

Clinical Results of Drug-Coated Balloon Treatment in a Large-Scale Multicenter Korean Registry Study

Cited by 7 publications

References 26 publications

Percutaneous coronary intervention with the staged mini culotte technique for ostial restenosis of the large side branch

Percutaneous coronary intervention with the staged mini culotte technique for ostial restenosis of the large side branch

Treatment of Peripheral Artery Disease Using Injectable Biomaterials and Drug-Coated Balloons: Safety and Efficacy Perspective

Factors influencing coronary artery target lesion revascularization after drug-coated balloon angioplasty

Contact Info

Product

Resources

About