Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

Kageji, Teruyoshi; Mizobuchi, Yoshifumi; Saijo, Nagahiro; Nakagawa, Yoshinobu; Kumada, Hiroaki

doi:10.1016/j.apradiso.2011.05.029

Cited by 42 publications

(26 citation statements)

References 6 publications

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“…Recently, the treatment of 23 patients with BNCT was reported in the study published by Kageji et al, where the mean survival was 19.5 months; and 26.1%, 17.4% and 5.8% of the patients had a survival of two years, three years and five years, respectively. The authors also suggest that the combination of the technique with TMZ would produce better results (29) .…”

Section: Discussionmentioning

confidence: 99%

Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

Brandão¹,

Campos

2013

Radiol Bras

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Objective Comparative analysis of dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for treatment of brain tumors. Materials and Methods Simulations of intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT were performed with the MCNP5 code, modeling the treatment of a brain tumor on a voxel computational phantom representing a human head. Absorbed dose rates were converted into biologically weighted dose rates. Results Intracavitary balloon catheter brachytherapy with I-125 produced biologically weighted mean dose rates of 3.2E-11, 1.3E-10, 1.9E-11 and 6.9E-13 RBE.Gy.h-1.p-1.s, respectively, on the healthy tissue, on the balloon periphery and on the I 1 and I 2 tumor infiltration zones. On the other hand, Cf-252 brachytherapy combined with BNCT produced a biologically weighted mean dose rate of 5.2E-09, 2.3E-07, 8.7E-09 and 2.4E-09 RBE.Gy.h-1.p-1.s, respectively on the healthy tissue, on the target tumor and on the I 1 and I 2 infiltration zones. Conclusion Cf-252 brachytherapy combined with BNCT delivered a selective irradiation to the target tumor and to infiltration zones, while intracavitary balloon catheter brachytherapy with I-125 delivered negligible doses on the tumor infiltration zones.

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Section: Discussionmentioning

confidence: 99%

Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

Brandão¹,

Campos

2013

Radiol Bras

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“…2009;Savolainen et.al. 2013;Kato et.al, 2004) or deep-seated tumors (Rao et.al, 2004;Kageji, 2011;Yamamoto, 2004;Kawabata, 2009). While a thermal neutron beam (E<1eV) is suitable for treating shallow tumors, the irradiation of epithermal neutron beam (1 eV≤ E ≤ 10 keV) for treatment of deeper tissues is examined in the literature (IAEA-TECDOC, 2001;Kiger III et.al, 2009;Marashi, 2000).…”

Section: Introductionmentioning

confidence: 96%

A study on the optimum fast neutron flux for Boron Neutron Capture Therapy of deep-seated tumors

Rasouli

Masoudi

2015

Applied Radiation and Isotopes

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“…6,7 At present, BNCT treatments have to be carried out at nuclear reactors. 6,8,9 These neutron sources are expensive and complex for most clinical settings, which ultimately limits the number of available BNCT facilities around the world and imposes heavy financial burden on the institutions. Nuclear reactors also have low public acceptability and require complicated licensing procedures.…”

Section: Introductionmentioning

confidence: 99%

A feasibility study of a deuterium–deuterium neutron generator‐based boron neutron capture therapy system for treatment of brain tumors

et al. 2017

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Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

Cited by 42 publications

References 6 publications

Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

Comparative dosimetry in intracavitary balloon catheter brachytherapy with I-125 and in Cf-252 brachytherapy combined with BNCT for brain tumors

A study on the optimum fast neutron flux for Boron Neutron Capture Therapy of deep-seated tumors

A feasibility study of a deuterium–deuterium neutron generator‐based boron neutron capture therapy system for treatment of brain tumors

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