Clinical Results After 5% Sodium Chloride Treatment in Post-operative Corneal Oedema

Abstract

Background: Evaluate the effectiveness of a hyperosmolar 5% sodium chloride treatment in corneal oedema.Design: This prospective, randomized study was conducted in a universitary ophthalmology department setting.Participants: 95 patients with post-operative corneal oedema were separated in 2 groups: 45 patients in group 1 treated with hypertonic eye drops; 50 patients in group 2 without anti-oedematous. Methods:Patients in group 1 were treated with 5% sodium chloride hypertonic eye drops associated with 0.15% sodium hyaluronate in addition to the classical post-operative treatment for 1 month; and patients in group 2 were only treated with classical post-operative treatment (antibiotic, corticosteroids and artificial tears). Main outcome measures:Visual acuity, pachymetry and density were measured at 1 day, 7 days, 1 month, 3 months and 6 months following surgery. Results:Visual acuity was significantly better in group 1 than in group 2 at 7 days (0.85 ± 0.64 logMAR vs. 1.46 ± 0.8 logMAR, p=0.024) and one month (0.42 ± 0.35 logMAR vs. 1.03 ± 0.86 logMAR, p=0.04) but was no longer different at three and six months. Pachymetry decreased significantly in 7 days in group 1 (decrease of 17%, p=0.04), contrary to group 2 (p=0.96), but the difference between the 2 groups was not statistically significant (p=0.15). Corneal density was also not significantly different between the two groups.Conclusion: 5% sodium chloride hypertonic eye drops reduces significantly post-operative corneal oedema treatment as shown by the improvement in visual acuity at one week and the downward trend in pachymetry.

Topical glycerine for corneal clouding during retinal laser photocoagulation for retinopathy of prematurity

“…Last but not least, another PHC session can be taken up later if the media does not permit further laser, which can be an added challenge. Two studies reported the effect of topical hypertonic saline on corneal edema without bullous keratopathy 4,5 Topical ocular hypertonic solutions act by increasing the tear film osmolality which in turn facilitates movement of sub-epithelial and intra-stromal fluid out of the cornea by osmosis. 6 The safety and efficacy of glycerine (5%) as a topical hypertonic agent in reducing corneal edema have been established.…”

Evaluation of the Effect of Hypertonic Saline Solution on Corneal Edema with Anterior Segment Optical Coherence Tomography and Cornea Densitometry

“…Kornea ödeminin tedavisinde hipertonik solüsyonlar kullanılabilir. 5,6 Literatürde, hipertonik solüsyonların korneada hangi tabakada düzelme sağladığını gösteren bir çalışma mevcut değildir. Bu çalışmada, katarakt cerrahisi geçiren ve kornea ödemi bulunan hastalarda, postoperatif erken dönemde kullanılan %5'lik hipertonik tuzlu su solüsyonu (HTS)'nun, AS-OKT ve kornea dansitometrisi (KD) kullanılarak, kornea üzerinde ne kadar ve hangi tabakalarda etki gösterdiğini kantitatif olarak değerlendirmektir.…”

“…12,15 Ho ve ark.nın yaptığı çalışmada, cerrahi sonrası HTS'lerin kornea ödemi üzerine etkisi değerlendirilmiştir. 5…”