Clinical responses of head &amp; neck tumors to radiation therapy by NIR spectroscopy

Sunar, Ulaş; Zhang, Jun; Du, Juan; Durdurán, Turgut; Zhou, Chao; Yu, Guoqiang; Kilger, Alex; Quon, Harry; Lustig, Robert A.; Loevner, Laurie A.; Nioka, Shoko; Pourrezaei, Kambiz; Yodh, Arjun G.; Chance, Britton

doi:10.1364/bio.2004.fb7

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Physiological images of total hemoglobin concentration, blood oxygenation, water and lipids are then derived from this information. Thus far DOT and DOS have generated a lot of scientific interest and have been applied in various deep-tissue applications including breast cancer imaging [62,69,102,116,119,144,165,191,194,213,222,300], brain functional imaging [80], stroke detection [23,63,133], muscle functional studies [148,226,285], photodynamic therapy [273,282], and radiation therapy monitoring [250].…”

Section: Diffuse Optical Spectroscopy and Tomographymentioning

confidence: 99%

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Diffuse optical tomography and spectroscopy of breast cancer and fetal brain

Choe

2005

Medical Physics

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Diffuse optical techniques utilize light in the near infrared spectral range to measure tissue physiology noninvasively. Based on these measurements, either average bulk optical properties or threedimensional spatial maps of tissue properties such as total hemoglobin concentration, blood oxygen saturation and scattering can be obtained using model-based reconstruction algorithms. In this thesis, diffuse optical techniques were applied for in vivo breast cancer imaging and transabdominal fetal brain oxygenation monitoring. For clinical in vivo breast cancer imaging, diffuse optical tomography technique and related instrumentation were developed. The clinical diffuse optical tomography instrument utilized near infrared light sources of multiple wavelengths, and multiple source-detector positions in a parallel plate geometry. Transmission continuous-wave measurements by a lens-coupled CCD camera and remission frequency-domain measurements by fiber-coupled detector channels were performed simultaneously. Human subject measurements were carried out in the prone position. The breast was softly compressed and the space adjacent to the breast was filled with a matching fluid with similar optical properties to that of the breast. A nonlinear conjugate gradient inverse algorithm with a priori spectral constraints was utilized to reconstruct threedimensional endogeneous optical and physiological breast properties. Bulk physiological properties were quantified for 52 healthy subjects in the parallel-plate transmission geometry. Threedimensional images of the breast were reconstructed for 21 subjects with breast carcinomas. Tumor contrast with respect to normal tissue was found in total hemoglobin concentration and scattering coefficient. An optical index combining total hemoglobin concentration and scattering coefficient shows the tumor contrast to be 2-3 times larger compared to the healthy tissue. Tumor contrast and tumor volume changes during neoadjuvant chemotherapy were tracked for one subject and compared to the dynamic contrast-enhanced magnetic resonance imaging ͑MRI͒. Our measurement revealed tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. Finally, the feasibility of measuring blood flow of breast tumors using optical methods was demonstrated for seven subjects. In a qualitatively different set of experiments, the feasibility of transabdominal fetal brain oxygenation monitoring was demonstrated on pregnant ewes with induced transient fetal hypoxia. Preliminary noninvasive clinical measurements before and after human Cesarean sections were discussed, identifying future directions. Overall, this research has translated diffuse optical tomography techniques into a clinical research environment.

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Section: Diffuse Optical Spectroscopy and Tomographymentioning

confidence: 99%

“…We happen within a week [140]. Then the treatment efficacy could be assessed in the similar approach taken by Yu et al [292], Wang et al [273] and Sunar et al [250]. We have recently acquired…”

Section: Summary and Future Outlookmentioning

confidence: 99%

Diffuse optical tomography and spectroscopy of breast cancer and fetal brain

Choe

2005

Medical Physics

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“…Thus far DOT has been applied in breast cancer imaging, [12][13][14][15][16][17][18][19][20][21][22][23] brain functional imaging, 25,27 stroke detection, 24,26 muscle functional study, 28,29 photodynamic therapy, 30,31 and radiation therapy monitoring. 68 Not surprisingly, use of DOT for detection and characterization of breast cancer has been of great recent interest. 14,[17][18][19][20][21][22][32][33][34][35][36][37][38][39][40][41] The functional information provided by DOT is complimentary to the morphological information obtained by traditional breast imaging modalities ͑i.e., x-ray mammogram, ultrasound, MRI͒.…”

Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI

et al. 2005

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We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.

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“…However, more frequent DOT measurements are desirable since the significant physiological changes relating to treatment efficacy may happen within a week [140]. Then the treatment efficacy could be assessed in the similar approach taken by Yu et al [292], Wang et al [273] and Sunar et al [250]. We have recently acquired DOT measurements with Indocyanine Green (ICG) injection for some neoadjuvant chemotherapy patients.…”

Section: Summary and Future Outlookmentioning

confidence: 99%

Diffuse Optical Tomography

Wang¹,

Wu²

2009

Biomedical Optics

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Most of all, I would like to thank volunteers and patients who participated in our clinical measurements for their generosity and courage towards developing research for the good of future generation.Lastly, I'd like to thank all my family and friends who have shaped who I am now. Among my friends, I single out devoted friends who were there for me throughout my graduate years. Marky, Saurav, Turgut and I formed a society µστ ρ exploring authentic ethnic cuisines from all around the world. Their adventurous spirits towards trying new things made a lot of fond memories. Also, I would like to thank compassionate Eylem for inviting me to dinners when I was too busy to cook while writing this thesis. I would like to thank Jamie for giving me a patient and caring instructions for the flight lessons. Through becoming a pilot, I have learned whole new level of self-control, patience as well as actual piloting skill and came to terms with my own abilities. My parents have always believed in me and supported me. My mother encouraged me to enjoy the moment while trying my best. My father has been the center and driving force for scientific mindset of our family.My brother Yookyung has shared his experties in medical illustrations by creating exceptionally fine illustrations used in my paper and thesis. Also, he has been there for me in my time of hardship along with Yujun and Agnes. I love them all.

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Clinical responses of head & neck tumors to radiation therapy by NIR spectroscopy

Cited by 6 publications

References 6 publications

Diffuse optical tomography and spectroscopy of breast cancer and fetal brain

Diffuse optical tomography and spectroscopy of breast cancer and fetal brain

Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI

Diffuse Optical Tomography

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