Clinical response to antidepressant treatment and 3-methoxy-4-hydroxyphenylglycol levels: mini review

Yoshimura, Reiji; Nakamura, Jun; Shinkai, Koji; Ueda, Nobuhisa

doi:10.1016/j.pnpbp.2004.01.008

Cited by 36 publications

(27 citation statements)

References 52 publications

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“…We are aware of the limitations of this study, in that plasma catecholamine metabolite, BDNF, cytokines appear to derive only in part from central sources (Yoshimura et al, 2003(Yoshimura et al, , 2004; in other words, plasma levels of catecholamine metabolites and BDNF only partially reflect the activities of the neurons in the brain. In addition, our sample size was very small and heterogeneous, we used an open flexible dose regime of risperidone, and most patients had been treated with lithium or valproic acid.…”

Section: Discussionmentioning

confidence: 95%

Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders

Yoshimura

Nakano

Hori

et al. 2006

Human Psychopharmacology

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A combination treatment with a mood stabilizer and an antipsychotic drug is often used in as many as 90% of subjects with acute mania. Recently, augmentation therapy with atypical antipsychotics has been investigated in both the acute and long-term treatment of bipolar disorder with or without psychosis. In the present study, the authors investigated the efficacy of risperidone treatment for both acute manic and depressive episodes in bipolar disorder. Eighteen patients (M/F: 8/10, age: 34 +/- 15 yr) who met the DSM-IV criteria for bipolar I disorder (12 cases of manic episodes, 6 cases of depressive episodes) with risperidone treatment were evaluated regarding their clinical improvement using the Young Mania rating Scale (YMRS) and the Hamilton rating Scale for Depression (Ham-D). Plasma concentrations of HVA and MHPG were analyzed by HPLC-ECD and plasma brain-derived neurotrophic factor (BDNF) levels were detected by sandwich ELISA. The mean scores of the YMRS were 22, 18, 12, 8, and 5 at time points before and 1, 2, 3, and 4 weeks after the risperidone administration, respectively. The mean scores of the Ham-D were 24, 25, 21, 21, and 19 at time points before and 1, 2, 3, and 4 weeks after the risperidone administration, respectively. The plasma levels of HVA and 3-methoxy-4-hydroxyphenylglycol (MHPG) were observed to have decreased 4 weeks after risperidone administration in manic patients. The levels did not change in depressive patients. The plasma levels of BDNF were decreased in depressive patients compared with manic patients or healthy controls. However, the administration of risperidone did not alter plasma BDNF levels.

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Section: Discussionmentioning

confidence: 95%

Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders

Yoshimura

Nakano

Hori

et al. 2006

Human Psychopharmacology

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“…The NE transporter (NET) is expressed in the presynaptic terminals of NE neurons and plays a critical role in NE reuptake and regulates the synaptic NE concentration [20,21]. The concentration of the NE metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) is considered to be a marker of central NE system activity [22]. Therefore, in addition to behavioral tests we elucidated the mechanisms responsible for the behavioral changes induced by ZD and/or SI through evaluations of the central NE system; i.e., of brain NE concentrations, NET expression, and blood MHPG concentrations.…”

Section: Introductionmentioning

confidence: 99%

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Mitsuya

Omata

Kiyono

et al. 2015

Behavioural Brain Research

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Nutritional and social environmental problems during the early stages of life are closely associated with the pathophysiology of mood disorders such as depression. Disruption or dysfunction of the central norepinephrine (NE) system is also considered to play a role in mood disorders. Therefore, we evaluated the effects of zinc deficiency and/or social isolation on mood and changes in the central NE system using rats. Compared with the controls, the rats subjected to zinc deficiency or social isolation alone exhibited increased anxiety-related behavior in the elevated plus maze and greater depression-like behavior in the forced swim test. However, the co-occurrence of zinc deficiency and social isolation resulted in decreased anxiety-related behavior and control levels of depression-like behavior. Social isolation alone decreased the rats' cerebral NE concentrations. The expression of the NE transporter was not affected by social isolation alone, but its expression in the locus coeruleus was markedly decreased by the co-occurrence of social isolation and zinc deficiency, and this change was accompanied by an increase in the blood concentration of 3-methoxy-4-hydroxyphenylglycol, which is a marker of central NE system activity. These findings suggest that zinc deficiency or social isolation alone induce anxious or depressive symptoms, but the presence of both conditions has anxiolytic or antidepressive effects. Furthermore, these opposing effects of mood-related behaviors were found to be associated with changes in the central NE system.

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“…In other words, patients with higher plasma MHPG levels had a better response to paroxetine. Patients with high anxiety levels have been reported to have high MHPG levels in their plasma or saliva (Yamada et al, 2000;Yoshimura et al, 2004). Taking these findings together, it is plausible that depressed patients with comorbid anxiety disorders might respond better to paroxetine than those with depression alone.…”

Section: Discussionmentioning

confidence: 99%

Rapid response to paroxetine is associated with plasma paroxetine levels at 4 but not 8 weeks of treatment, and is independent of serotonin transporter promoter polymorphism in Japanese depressed patients

Yoshimura

Umene-Nakano

Suzuki

et al. 2009

Human Psychopharmacology

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In the present study, we investigated the relationship between the serotonin transporter gene linked polymorphic regions (5-HTTLPR) or plasma paroxetine levels and clinical response to paroxetine in depressed patients. Sixty patients who met the DSM-IV criteria for major depressive disorder were enrolled in the study. Twenty-two were male and 38 were female, with ages ranging from 25 to 71 (mean +/- SD = 42 +/- 16) years. The clinical improvement of patients was assessed using the Hamilton rating scale for depression (Ham-D) before and every week after paroxetine administration. According to the data reported previously, patients with an at least 50% decrease in their Ham-D score were classified as responders. The results showed that the plasma paroxetine levels at 4 weeks were significantly higher in responders (rapid responders) than in nonresponders. On the other hand, no significant associations were found between the L genotype (L/L, L/S) or S genotype (S/S) and the response rates either at 4 weeks or 8 weeks. These results suggest that patients with higher plasma levels at 4 weeks might respond rapidly to paroxetine treatment, but the final response rate at 8 weeks will be independent of the plasma paroxetine levels and the 5-HTTLPR L/S genotype.

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Clinical response to antidepressant treatment and 3-methoxy-4-hydroxyphenylglycol levels: mini review

Cited by 36 publications

References 52 publications

Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders

Effect of risperidone on plasma catecholamine metabolites and brain‐derived neurotrophic factor in patients with bipolar disorders

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Rapid response to paroxetine is associated with plasma paroxetine levels at 4 but not 8 weeks of treatment, and is independent of serotonin transporter promoter polymorphism in Japanese depressed patients

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