Clinical Research on Traditional Chinese Medicine compounds and their preparations for Amyotrophic Lateral Sclerosis

Zhu, Jiayi; Shen, Lan; Lin, Xiao; Yang, Hong; Feng, Yi

doi:10.1016/j.biopha.2017.09.135

Cited by 24 publications

(39 citation statements)

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“…TCM has been reported about unique advantages in autoimmune neuritis, demyelinating and neurodegenerative diseases (such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, autoimmune encephalomyelitis, etc.) [10][11][12][13][14][15][16][17][18]. In our pilot clinical experiment, we observed that when combined an empirical TCM formula with the current treatment of GBS, better outcomes could be acquired.…”

Section: Tcm Syndrome Scorementioning

confidence: 99%

“…There were 28 subjects in the control group, including 19 males and 9 females, aged 10 to 67 (37.8±14.0) years, among which 22 cases had prodromal symptoms within 2 weeks before onset. The mean time since onset was 6.3 days [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. There were 5 mild cases, 17 moderate, and 6 severe cases.…”

Section: Clinical Features Of Patientsmentioning

confidence: 99%

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Integrated Chinese and western medicine for acute guillain-barré syndrome treatment

Yang¹,

Zhao

2020

Translational Neuroscience

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AbstractIntroductionGuillain-Barré syndrome (GBS) is a worldwide demyelinating polyradiculopathy and polyneuropathy. Currently, there is no specific drug for GBS, and established treatment is generally based on immune-modulating treatment with plasma exchange or intravenous immunoglobulin in combination with supportive care. This study aimed to investigate the efficiency of integrated Chinese and Western medicine for acute GBS treatment.MethodsWe enrolled 73 subjects, and randomly divided them into two groups: 35 cases in the traditional Chinese medicine (TCM) group, and 28 in the Control group. The Control group was treated with the common Western medicine for one month; and the TCM group was administrated with one month of common treatment combined with TCM medication.ResultsCompared to the controls, TCM significantly enhanced the treatment efficiency in symptom expression, including the TCM syndrome score, the activity of daily living score, Hughes functional score and sensory dysfunction assessment. The total effective rate of the TCM group was 94.29%, significantly better than controls (78.59%). Moreover, TCM provide better improvement in motor nerve conduction functions (distal motor latency and motor conduction velocity) and sensory nerve conduction functions (sensory conduction velocity and sensory nerve action potential) in median nerve, ulnar nerve, and common fibular nerve.ConclusionWhen combined with TCM administration, the GBS treatment could acquire better outcomes.

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Section: Tcm Syndrome Scorementioning

confidence: 99%

Section: Clinical Features Of Patientsmentioning

confidence: 99%

Integrated Chinese and western medicine for acute guillain-barré syndrome treatment

Yang¹,

Zhao

2020

Translational Neuroscience

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“…[ 6 ] Over 60 other molecules have been investigated as potential treatments for ALS, but the clinical effects are not good. [ 7 ] Traditional Chinese medicine (TCM) is being more and more applied in the treatment of ALS, a large number of clinical data confirmed that the compound Chinese medicine have good effect to improve symptoms, [ 8 ] treatment based on syndrome differentiation according to the different groups in the treatment of ALS have advantages of multiple targets, multiple ways, less side effects, and low cost, as same as against oxidative stress, excitatory amino acid toxicity, neuroinflammation, and calcium cytotoxicity, etc. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of Chinese herbal compound combined with western medicine for amyotrophic lateral sclerosis

et al. 2020

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Background: Traditional Chinese medicine (TCM) compound formulations are selected according to different populations, with strong targeting and less adverse reactions. As a complex disease, amyotrophic lateral sclerosis (ALS) has limited efficacy in the use of conventional treatment regiments, short life cycle, high cost, many side effects, and low quality of life. It is urgent to seek new alternative therapies. Clinical practice shows that Chinese herbal compound combined with western medicine has certain therapeutic advantages, but there is no evidence of evidence-based medicine. The purpose of this study was to evaluate the efficacy and safety of Chinese herbal compound combined with western medicine in the treatment of ALS. Methods: Use computer to retrieve English database (PubMed, Embase, Web of Science, the Cochrane Library) and Chinese database (CNKI, Wanfang Database, Weipu database, and China Biomedical Literature Service System), moreover manually retrieve Baidu academic and Google academic from the establishment of the database to 2020 July for randomized controlled clinical study on ALS treated with compound Chinese medicine with western medicine therapy, 2 researchers independently conducted data extraction and literature quality evaluation on the quality of the included studies, and meta-analysis of the included literature was carried out using RevMan5.3 software. Results: This study evaluated the efficacy and safety of TCM combined with western medicine in the treatment of ALS by means of effective rate, improved Norris scale, ALS Functional Rating Scale, TCM syndrome score, and adverse reaction incidence. Conclusion: This study will provide reliable evidence for the clinical application of Chinese herbal compound combined with western medicine in the treatment of ALS. OSF registration number: DOI 10.17605/OSF.IO/R5XG4

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“…It has been reported that traditional Chinese medicine might be beneficial to improve symptoms and prolong the survival of patients with ALS . Hirsutella sinensis (HS, also known as Cordyceps sinensis, Chinese caterpillar fungus or “Dong Chong Xia Cao” in Chinese, Figure A) is a unique fungus growing on caterpillars and is a highly valued tonic medicine claimed to treat a wide range of disorders, such as asthma, chronic kidney disease, and kidney transplant recipients .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1^G93A transgenic mouse model

Shang

Zhang

et al. 2019

CNS Neurosci Ther

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AimsAlthough the pathophysiology of amyotrophic lateral sclerosis (ALS) is still not completely understood, the deregulated microglia polarization and neuroinflammation have been shown to contribute to the pathogenesis and progression of this disease. In the present study, we aimed to determine whether hirsutella sinensis (HS) could reduce neuroinflammatory and pathological changes in the spinal cord of SOD1G93A model mice of ALS and consequently ameliorate disease onset and progression.MethodsSOD1G93A mice were chronically treated with HS by gavage. Their lifespan was recorded, and motor behavior was evaluated by rotarod test. The pathological changes in skeletal muscles and motor neurons in spinal cords were assessed by immunofluorescent staining and hematoxylin‐eosin staining. The microglia activation and neuroinflammation were determined by immunofluorescent staining and RT‐PCR.ResultsOur data suggested that repeated HS administration prolonged the lifespan and extended disease duration of ALS mice without significant delay on disease onset. HS ameliorated the pathological changes in the motor neurons and gastrocnemius muscles. Moreover, HS promoted the transition of microglia from pro‐inflammatory M1 to anti‐inflammatory M2 phenotype in the spinal cord of ALS mice.ConclusionAll these findings indicate that HS may serve as a potential therapeutic candidate for the treatment of ALS.

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Clinical Research on Traditional Chinese Medicine compounds and their preparations for Amyotrophic Lateral Sclerosis

Cited by 24 publications

References 105 publications

Integrated Chinese and western medicine for acute guillain-barré syndrome treatment

Integrated Chinese and western medicine for acute guillain-barré syndrome treatment

The efficacy and safety of Chinese herbal compound combined with western medicine for amyotrophic lateral sclerosis

Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1^G93A transgenic mouse model

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Clinical Research on Traditional Chinese Medicine compounds and their preparations for Amyotrophic Lateral Sclerosis

Cited by 24 publications

References 105 publications

Integrated Chinese and western medicine for acute guillain-barré syndrome treatment

Integrated Chinese and western medicine for acute guillain-barré syndrome treatment

The efficacy and safety of Chinese herbal compound combined with western medicine for amyotrophic lateral sclerosis

Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1G93A transgenic mouse model

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Product

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Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1^G93A transgenic mouse model