Clinical Research of Huatan Quyu Formula on the Treatment of Type 2 Diabetes Mellitus Combined with Non-Alcoholic Fatty Liver Disease

Abstract

To observe the clinical effect of Huatan Quyu granules on type 2 diabetes mellitus combined with nonalcoholic fatty liver disease. A total of 60 patients who met the inclusion criteria were selected from the Department of Endocrinology in the Southern District of Guang'anmen Hospital from January 2018 to December 2019. Thirty patients in the control group were treated with metformin hydrochloride tablets and thirty patients in the treatment group were additionally treated with Huatan Quyu granules after given by metformin hydrochloride tablets. Patients in both groups were treated for 12 w. The blood sugar (fasting plasma glucose, 2 h post-load plasma glucose, hemoglobin A1C), the blood lipids (triglyceride, low-density lipoprotein, high-density lipoprotein, total cholesterol), homeostatic model assessment of insulin resistance and changes in traditional Chinese medicine symptoms of the two groups were compared and analyzed. The total effective rate of traditional Chinese medicine symptoms was better in the treatment group compared with in the control group (p<0.05); the scores of traditional Chinese medicine symptoms, i.e., fullness in the abdomen and stomach, hidden pain under the hypochondrium, dizziness, drowsiness and tastelessness in the mouth, increased in the treatment group after treatment compared with those before treatment and the control group (p<0.05). The fasting plasma glucose, 2 h post-load plasma glucose, hemoglobin A1C, fasting insulin levels, homeostatic model assessment of insulin resistance, triglyceride, total cholesterol, low-density lipoprotein were lower in the treatment group after treatment compared with those before treatment and the control group (p<0.05). Huatan Quyu granules can reduce the biochemical indexes related to glucose and lipids in patients with type 2 diabetes mellitus combined with non-alcoholic fatty liver disease, alleviate insulin resistance and improve the clinical symptoms of patients. It has a good application prospect.