Clinical, Research, and Public Health Implications of Poor Measurement of Vitamin D Status

Lucas, Robyn; Gorman, Shelley; Black, Lucinda J

doi:10.5740/jaoacint.17-0082

Cited by 16 publications

(16 citation statements)

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“…Amongst subjects with data on SNPs and vitamin D level (1343 in total), 320 women (165 cases, 155 control subjects) were also subjects in the cardiovascular cohort. There is no consensus regarding adequate levels of vitamin D, and the levels vary substantially over the year; thus it is not possible to clinically define a high or low vitamin D level on a single measurement [ 20 ]. In this study, the median level of vitamin D of each calendar month of sampling was used as a cut-off between low and high levels of vitamin D.…”

Section: Methodsmentioning

confidence: 99%

SNPs related to vitamin D and breast cancer risk: a case-control study

et al. 2018

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BackgroundIt has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) to be associated with vitamin D. The aim of this study was to investigate such vitamin D-SNP associations in relation to subsequent breast cancer risk. A first step included verification of these SNPs as determinants of vitamin D levels.MethodsThe Malmö Diet and Cancer Study included 17,035 women in a prospective cohort. Genotyping was performed and was successful in 4058 nonrelated women from this cohort in which 865 were diagnosed with breast cancer. Levels of vitamin D (25-hydroxyvitamin D) were available for 700 of the breast cancer cases and 643 of unaffected control subjects. SNPs previously associated with vitamin D in GWASs were identified. Logistic regression analyses yielding ORs with 95% CIs were performed to investigate selected SNPs in relation to low levels of vitamin D (below median) as well as to the risk of breast cancer.ResultsThe majority of SNPs previously associated with levels of vitamin D showed a statistically significant association with circulating vitamin D levels. Heterozygotes of one SNP (rs12239582) were found to have a statistically significant association with a low risk of breast cancer (OR 0.82, 95% CI 0.68–0.99), and minor homozygotes of the same SNP were found to have a tendency towards a low risk of being in the group with low vitamin D levels (OR 0.72, 95% CI 0.52–1.00). Results from stratified analyses showed diverse associations with breast cancer risk for a few of the tested SNPs, depending on whether vitamin D level was high or low.ConclusionsSNPs associated with vitamin D may also be associated with the risk of breast cancer. Even if such a risk is small, the allele frequency of the SNP variants is high, and therefore the population attributable risk could be substantial. It is also possible that vitamin D levels may interact with genomic traits with regard to breast cancer risk.Electronic supplementary materialThe online version of this article (doi:10.1186/s13058-017-0925-3) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

SNPs related to vitamin D and breast cancer risk: a case-control study

et al. 2018

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“…Although the importance of vitamin D has been recognized in recent years, there is no clear consensus on the definition of VDD [ 51 , 52 , 53 ]. Generally, vitamin D supplementation is recommended for pregnant women and newborns [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis

et al. 2018

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Influenza virus infection is a major global public health problem, and the efficacy of influenza vaccination is not satisfactory. Vitamin D is involved in many immune-mediated inflammatory processes. The impact of vitamin D levels on the immunogenic response to influenza vaccination is not clear. We performed a comprehensive literature search and systematic review of studies that investigated vitamin D and influenza vaccination. Data pertaining to study population, vaccine components, vitamin D levels, and immunogenic response were analyzed. Nine studies, with a combined study population of 2367 patients, were included in the systematic review. Four studies were included in the meta-analysis to investigate the influence of vitamin D deficiency (VDD) on the seroprotection (SP) rates and seroconversion (SC) rates following influenza vaccination. We found no significant association between vitamin D level and the immunogenic response to influenza vaccination. However, strain-specific differences may exist. We observed lower SP rates of influenza A virus subtype H3N2 (A/H3N2) and B strain in VDD patients than patients with normal vitamin D levels (A/H3N2: 71.8% vs. 80.1%, odds ratio (OR): 0.63, 95% confidence interval (CI): 0.43–0.91, p = 0.01; B strain: 69.6% vs. 76.4%, OR: 0.68, 95% CI: 0.5–0.93, p = 0.01). However, the SP rates of A/H1N1 and SC rates of all three strains were not significantly different in VDD and control groups. In conclusion, no association was observed between VDD and immunogenic response to influenza vaccination.

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“…Usually, the validation of new 25-vitamin D assays is done through the comparison with HPLC results. [5][6][7] However, the CKD population is either not well represented or excluded from these studies. 2,4,[8][9][10] In this study, we investigated the impact of various stages of CKD on the variability between two chemiluminescence assays for 25-vitamin D.…”

Section: Introductionmentioning

confidence: 99%

Chronic kidney disease is a main confounding factor for 25-vitamin D measurement

et al. 2020

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Background: Current guidelines recommend assessment of 25-vitamin D status in patients with chronic kidney disease (CKD). Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability between two 25-vitamin D assays in patients with CKD (eGFR < 60 mL/min/1.73m2) who had consecutive 25-vitamin D measurements in 2015 (Assay 1 - Diasorin LIASON 25 TOTAL - D assay®) and 2016 (Assay 2 - Beckman Coulter Unicel Xl 800®). The cohort consisted of 791 adult patients (122 with normal renal function and 669 with CKD - 33, 30, and 37% in stages 3, 4, and 5 on dialysis, respectively). Results: Levels of 25-vitamin D were lower and the prevalence of hypovitaminosis D using assay 1 was higher than using assay 2 in patients with CKD, regardless of similar levels of calcium, phosphate, and parathyroid hormone. As kidney function decreased, the percentage of disagreement between the assays increased. Conclusion: There is a noteworthy variability between assays in patients with CKD such that the diagnosis of hypovitaminosis D is modified. The mechanism behind this result is still unclear and might be due to a possible interference in the analytical process. However, the clinical significance is unquestionable, as the supplementation of vitamin D can be erroneously prescribed to these patients.

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Clinical, Research, and Public Health Implications of Poor Measurement of Vitamin D Status

Cited by 16 publications

References 0 publications

SNPs related to vitamin D and breast cancer risk: a case-control study

SNPs related to vitamin D and breast cancer risk: a case-control study

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis

Chronic kidney disease is a main confounding factor for 25-vitamin D measurement

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