Clinical report of a paralytic syndrome affecting stallions, mares and foals on a Thoroughbred studfarm

Greenwood, R. E. S.; Simson, A. R. B.

doi:10.1111/j.2042-3306.1980.tb03397.x

Cited by 70 publications

(38 citation statements)

References 3 publications

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“…Nonetheless, EHM has been reported in horses of all ages (Greenwood and Simson, 1980;Friday et al, 2000). Breed was different between groups in the present study, with more saddle horses in the EHM group.…”

Section: Discussioncontrasting

confidence: 33%

A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008–2011)

Galen

Leblond

Tritz³

et al. 2015

Veterinary Microbiology

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Please cite this article as: Galen, Gaby van, Leblond, Agnes, Tritz, Pierre, Martinelle, Ludovic, Pronost, Stéphane, Saegerman, Claude, A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008France ( -2011.Veterinary Microbiology http://dx.doi.org/10. 1016/j.vetmic.2015.07.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and geographic location, risk factors were found to be similar to previous studies, therefore strengthening their significance to the spread of EHM.

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Section: Discussioncontrasting

confidence: 33%

A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008–2011)

Galen

Leblond

Tritz³

et al. 2015

Veterinary Microbiology

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“…Clinical details of these horses were quite similar to those of horses suffered paralytic form of EHV-1 infection described by several researchers [8,12,13,31,34]. Furthermore, pathological findings from post mortem samples of 2 of the 7 horses described by Wada et al [32] were consistent with the former descriptions of EHV-1 infected horses with neurological disease [5,13,14,18,19,24].…”

Section: Discussionsupporting

confidence: 84%

Sero- and Molecular-Epizootiological Studies on Equine Herpesvirus Type 1(EHV-1) Infection among Race Horses: an Occurrence of Respiratory Disease with Nervous Disorders.

Matsumurai

Yokota

Imagawa

et al. 1994

JES

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Among race horses raised and trained at Ritto Training Center of the Japan Racing Association, an epizootic of respiratory disease was observed from January to February in 1989. During the epizootic, a total of 155 out of approximately 2,000 race horses developed pyrexia. Following the respiratory symptoms, 7 Thoroughbred horses showed various degree of nervous disorders such as incoordination of the hind limbs to recumbency with urinary incontinence. Previous study briefly reported a result of virus isolation, in which 10 EHV-1 strains were isolated from febrile horses involved in this epizootic. In this study, clinical, serological, and molecular-biological researches were conducted to elucidate an epizootiological aspect of this occurrence of EHV-1 infection. Serologically, 90 (67.7%), including 7 samples from the horses manifested nervous disorders, out of 133 paired serum samples collected from febrile horses showed significant antibody response (four-fold or greater increase in the antibody titer) against EHV-1 by complement fixation and/or serum neutralization tests. Majority (more than 85%) o f the infected horses as judged by serological tests were 3 years old. By restriction enzyme and Southern blot analyses o f DNAs extracted from 10 EHV-1 isolates, including an isolate from one of the 7 horses manifested nervous disorders, the Bam HI cleavage pattern corresponded to that of the electropherotype 1 P of EHV-1 and closely resembled each other. However, minor variations were detected in the electrophoretic mobilities of certain Bam HI fragments. These results confirmed that the epizootic of respiratory disease occurred among race horses at Ritto Training Center in 1989 was caused by EHV-1 infection, and strongly suggest that the nervous disorders observed among febrile horses involved in the epizootic were caused by the paralytic form of EHV-1 infection, which had never been recognized among horses in Japan. However, no distinct difference was detected between DNAs o f the isolate from a horse with paralysis and of the isolates from horses without paralysis in the Bam HI restriction profile.

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“…THE paralytic form of Equid herpesvirus type 1 (EHV-I) infection i s rarely reported in the UK. In 1979 there were multiple cases on a Newmarket studfarm and eight mares died: clinical and pathological findings were recorded (Greenwood and Simson 1980;Platt, Singh and Whitwell 1980). Another paresis outbreak affecting eight mares occurred in Dorset in 1980, but there were no deaths (Crowhurst, Dickinson and Burrows 1981).…”

Section: Introductionmentioning

confidence: 99%

Pathological findings in horses dying during an outbreak of the paralytic form of Equid herpesvirus type 1 (EHV‐1) infection

Whitwell

Blunden

1992

Equine Veterinary Journal

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Summary In 1988 an outbreak of the paralytic form of Equid herpesvirus type 1 (EHV‐1) infection occurred on a stud farm and several animals died. This provided an opportunity to perform detailed pathological investigations to gain insights into the pathogenesis of this spontaneous disease. Two paretic mares, three foals, an aborted foetus and its non‐paretic dam were examined. The endotheliotropism of the virus was clearly demonstrated by the use of an indirect immunoperoxidase (IP) stain. At autopsy, evidence of viral infection was widespread in the foetus and foals, but limited or absent in the mares, probably reflecting differences in their immune status. Vascular lesions were present in the central nervous system (CNS) of the foals as well as the adults; they resulted in minimal neural lesions in the foals. Severe changes in the upper and lower respiratory tracts were a particular feature in the foals, two of which exhibited extensive vasculitis and thrombosis in the lungs. The IP technique was of great value in locating antigen‐containing cells in the CNS of one mare when virus isolation was negative. It also revealed the presence of virus in less well documented sites such as the pancreas, gut, thyroid, uveal tract and the skin of the nares.

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Clinical report of a paralytic syndrome affecting stallions, mares and foals on a Thoroughbred studfarm

Cited by 70 publications

References 3 publications

A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008–2011)

A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008–2011)

Sero- and Molecular-Epizootiological Studies on Equine Herpesvirus Type 1(EHV-1) Infection among Race Horses: an Occurrence of Respiratory Disease with Nervous Disorders.

Pathological findings in horses dying during an outbreak of the paralytic form of Equid herpesvirus type 1 (EHV‐1) infection

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